NP
Primary Info
Mutation
Mouse studies
DNA sequencing


External links Primary Information
MGI:97365
ENSMUSG00000021871
Gene Symbol Pnp1
Affected Anatomical Systems hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,lethality-prenatal/perinatal,renal/urinary system phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id
MGI:3777967 Pnp1e Chemically induced (ENU) NP-1E 2516826
MGI:3777968 Pnp1f Chemically induced (ENU) NP-1F 2516826
MGI:3777975 Pnp1g Chemically induced (ENU) NP-1G 1781357
MGI:3777976 Pnp1h Chemically induced (ENU) NP-1H 1781357
MGI:3777978 Pnp1i Chemically induced (ENU) NP-1I 1781357
MGI:2386195 Pnp1tm1Cmr Targeted (knock-out) targeted mutation 1, Chaim M Roifman 10859343
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id
Abnormal Kidney Excretion Pnp1e>/Pnp1 involves: C3H/HeHa * C57BL/6J 2516826
Abnormal Enzyme/coenzyme Activity Pnp1e>/Pnp1 involves: C3H/HeHa * C57BL/6J 2516826
Thymus Hypoplasia Pnp1e>/Pnp1 C57BL/6J-Pnp1 9122228
Increased Double-negative T Cell Number Pnp1f>/Pnp1 involves: C3H/HeHa * C57BL/6J 1781357
Abnormal Kidney Excretion Pnp1f>/Pnp1 involves: C3H/HeHa * C57BL/6J 2516826
Abnormal Enzyme/coenzyme Activity Pnp1f>/Pnp1 involves: C3H/HeHa * C57BL/6J 2516826
Thymus Hypoplasia Pnp1f>/Pnp1 C57BL/6J-Pnp1 9122228
Abnormal Leukocyte Cell Number Pnp1f>/Pnp1 C57BL/6J-Pnp1 9122228
Decreased Double-positive T Cell Number Pnp1f>/Pnp1 C57BL/6J-Pnp1 9122228
Decreased CD8-positive T Cell Number Pnp1f>/Pnp1 C57BL/6J-Pnp1 9122228
Embryonic Lethality During Organogenesis Pnp1g>/Pnp1 involves: C57BL/6J 1781356
Prenatal Lethality Pnp1g>/Pnp1 involves: C57BL/6 * DBA/2J 1781356
Thymus Hypoplasia Pnp1g>/Pnp1 involves: C57BL/6 * DBA/2J 9122228
Abnormal Leukocyte Cell Number Pnp1g>/Pnp1 involves: C57BL/6 * DBA/2J 9122228
Increased Double-negative T Cell Number Pnp1g>/Pnp1 involves: C57BL/6 * DBA/2J 9122228
Decreased Double-positive T Cell Number Pnp1g>/Pnp1 involves: C57BL/6 * DBA/2J 9122228
Abnormal Enzyme/coenzyme Activity Pnp1g>/Pnp1 involves: C57BL/6 * DBA/2J 1781357
Decreased CD8-positive T Cell Number Pnp1g>/Pnp1 involves: C57BL/6 * DBA/2J 9122228
Abnormal Enzyme/coenzyme Activity Pnp1h>/Pnp1 involves: C3H/HeHa * C57BL/6J 1781357
Abnormal Enzyme/coenzyme Activity Pnp1i>/Pnp1 involves: C3H/HeHa * C57BL/6J 1781357
Increased Cellular Sensitivity To Gamma-irradiation Pnp1tm1Cmr>/Pnp1 involves: 129 10859343
Abnormal Myelopoiesis Pnp1tm1Cmr>/Pnp1 involves: 129 10859343
Defective Cytotoxic T Cell Cytolysis Pnp1tm1Cmr>/Pnp1 involves: 129 10859343
Increased Double-negative T Cell Number Pnp1tm1Cmr>/Pnp1 involves: 129 10859343
Decreased Double-positive T Cell Number Pnp1tm1Cmr>/Pnp1 involves: 129 10859343
Abnormal Enzyme/coenzyme Activity Pnp1tm1Cmr>/Pnp1 involves: 129 10859343
Increased Pre-B Cell Number Pnp1tm1Cmr>/Pnp1 involves: 129 10859343
Abnormal Mitochondrial Physiology Pnp1tm1Cmr>/Pnp1 involves: 129 10859343
Abnormal DNA Repair Pnp1tm1Cmr>/Pnp1 involves: 129 10859343
Decreased CD4-positive T Cell Number Pnp1tm1Cmr>/Pnp1 involves: 129 10859343
Decreased CD8-positive T Cell Number Pnp1tm1Cmr>/Pnp1 involves: 129 10859343
Decreased Single-positive T Cell Number Pnp1tm1Cmr>/Pnp1 involves: 129 10859343
Increased Thymocyte Apoptosis Pnp1tm1Cmr>/Pnp1 involves: 129 10859343
Abnormal Urine Homeostasis Pnp1tm1Cmr>/Pnp1 involves: 129 10859343