STAT1
Primary Info
Mutation
Mouse studies
DNA sequencing


External links Primary Information
MGI:103063
ENSMUSG00000026104
Gene Symbol Stat1
Affected Anatomical Systems cardiovascular system phenotype,cellular phenotype,digestive/alimentary phenotype,growth/size phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,lethality-postnatal,life span-post-weaning/aging,limbs/digits/tail phenotype,liver/biliary system phenotype,muscle phenotype,nervous system phenotype,skeleton phenotype,tumorigenesis,vision/eye phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id
MGI:3611892 Stat1fae Chemically induced (ENU) face
MGI:3619019 Stat1m1Btlr Chemically induced (ENU) mutation 1, Bruce Beutler 16688530
MGI:3785244 Stat1m2Btlr Chemically induced (ENU) mutation 2, Bruce Beutler
MGI:1930947 Stat1tm1Dlv Targeted (knock-out) targeted mutation 1, David E Levy 8608598
MGI:1861949 Stat1tm1Rds Targeted (knock-out) targeted mutation 1, Robert D Schreiber 8608597
MGI:3774319 Stat1tm1Tdec Targeted (knock-in) targeted mutation 1, Thomas Decker 14670297
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id
Increased Susceptibility To Bacterial Infection Stat1tm1Rds>/Stat1 either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) 8608597
Increased Susceptibility To Viral Infection Stat1tm1Rds>/Stat1 either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) 8608597
Abnormal Cell Physiology Stat1tm1Rds>/Stat1 either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) 8608597
Decreased Body Size Stat1tm1Dlv>/Stat1 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1) 8608598
Abnormal Intestine Morphology Stat1tm1Dlv>/Stat1 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1) 8608598
Abnormal Leukocyte Physiology Stat1tm1Dlv>/Stat1 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1) 8608598
Increased Susceptibility To Viral Infection Stat1tm1Dlv>/Stat1 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1) 8608598
Multifocal Hepatic Necrosis Stat1tm1Dlv>/Stat1 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1) 8608598
Lethality At Weaning Stat1tm1Dlv>/Stat1 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1) 8608598
Abnormal Cornea Morphology Stat1tm1Rds>/Stat1 involves: 129/Sv 10865997
Increased Susceptibility To Viral Infection Stat1tm1Rds>/Stat1 involves: 129/Sv 11390995
Abnormal Cell Cycle Stat1tm1Rds>/Stat1 involves: 129/Sv 14617019
Decreased Apoptosis Stat1tm1Rds>/Stat1 involves: 129/Sv 10865997
Abnormal Common Myeloid Progenitor Cell Morphology Stat1tm1Rds>/Stat1 involves: 129/Sv 14617019
Increased Susceptibility To Viral Infection Stat1tm1Dlv>/Stat1 B6.129-Stat1 11390995
Abnormal T Cell Activation Stat1fae>/Stat1 C57BL/6Apb-Stat1/Apb
Increased IgG Level Stat1fae>/Stat1 C57BL/6Apb-Stat1/Apb
Abnormal T-helper 2 Physiology Stat1fae>/Stat1 C57BL/6Apb-Stat1/Apb
Increased Susceptibility To Viral Infection Stat1m1Btlr>/Stat1 C57BL/6J-Stat1 16688530
Abnormal Macrophage Physiology Stat1m1Btlr>/Stat1 C57BL/6J-Stat1 16688530
Altered Tumor Susceptibility Stat1tm1Rds>/Stat1 C3.129-Stat1 16618773
Increased Infarction Size Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 12223448
Decreased Apoptosis Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 17475277
Abnormal Redox Activity Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 17475277
Increased Cardiomyocyte Apoptosis Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 12223448
Abnormal Nitric Oxide Homeostasis Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 17475277
Increased NK T Cell Number Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 17475277
Decreased Susceptibility To Neuronal Excitotoxicity Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 17078933
Decreased Circulating Interferon-gamma Level Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 17475277
Abnormal Tibia Morphology Stat1tm1Rds>/Stat1 B6.129-Stat1 12923053
Increased Bone Mass Stat1tm1Rds>/Stat1 B6.129-Stat1 12923053
Abnormal Long Bone Morphology Stat1tm1Rds>/Stat1 B6.129-Stat1 12923053
Increased Osteoclast Cell Number Stat1tm1Rds>/Stat1 B6.129-Stat1 12923053
Increased Bone Resorption Stat1tm1Rds>/Stat1 B6.129-Stat1 12923053
Abnormal Osteoblast Differentiation Stat1tm1Rds>/Stat1 B6.129-Stat1 12923053
Increased Susceptibility To Viral Infection Stat1m2Btlr>/Stat1 C57BL/6J-Stat1
Impaired NK Cell Cytolysis Stat1m2Btlr>/Stat1 C57BL/6J-Stat1
Decreased Interferon-gamma Secretion Stat1m2Btlr>/Stat1 C57BL/6J-Stat1
Decreased NK Cell Degranulation Stat1m2Btlr>/Stat1 C57BL/6J-Stat1
Increased Susceptibility To Bacterial Infection Stat1tm1Dlv>/Stat1 involves: 129S/SvEv 14670297
Increased Susceptibility To Viral Infection Stat1tm1Dlv>/Stat1 involves: 129S/SvEv 14670297
Decreased Level Of Surface Class I Molecules Stat1tm1Dlv>/Stat1 involves: 129S/SvEv 14670297
Abnormal MHC II Cell Surface Expression On Macrophages Stat1tm1Dlv>/Stat1 involves: 129S/SvEv 14670297
Increased Circulating Interferon-gamma Level Stat1tm1Dlv>/Stat1 involves: 129S/SvEv 14670297
Decreased Susceptibility To Endotoxin Shock Stat1tm1Dlv>/Stat1 involves: 129S/SvEv 14670297
Increased Susceptibility To Bacterial Infection Stat1tm1Tdec>/Stat1 involves: 129P2/OlaHsd * BALB/c 14670297
Increased Susceptibility To Viral Infection Stat1tm1Tdec>/Stat1 involves: 129P2/OlaHsd * BALB/c 14670297
Abnormal Macrophage Physiology Stat1tm1Tdec>/Stat1 involves: 129P2/OlaHsd * BALB/c 14670297
Abnormal MHC II Cell Surface Expression On Macrophages Stat1tm1Tdec>/Stat1 involves: 129P2/OlaHsd * BALB/c 14670297
Decreased Susceptibility To Endotoxin Shock Stat1tm1Tdec>/Stat1 involves: 129P2/OlaHsd * BALB/c 14670297
Abnormal NK Cell Physiology Stat1tm1Dlv>/Stat1 B6.129S-Stat1 12370359
Impaired NK Cell Cytolysis Stat1tm1Dlv>/Stat1 B6.129S-Stat1 12370359
Increased Circulating Interferon-gamma Level Stat1tm1Dlv>/Stat1 B6.129S-Stat1 12370359
Increased Circulating Interleukin-12b Level Stat1tm1Dlv>/Stat1 B6.129S-Stat1 12370359