TNFRSF13B
Primary Info
Mutation
Mouse studies
DNA sequencing


mRNA IDs Primary Information
NM_012452.2 Gene Symbol TNFRSF13B
Protein Name Tumor necrosis factor receptor superfamily, member 13b
Alternate Names CD267, CVID, FLJ39942, MGC133214, MGC39952, TACI, TNFRSF14B
Gene Locus 17p11.2

External links
IDR HPRD OMIM Entrez Gene NetPath Reactome PDB HGNC Ensembl Swiss-Prot RefDIC
153 05365 604907 23495 1XU1
1XUT
18153 ENSG00000108516 O14836 TNFRSF13B

Disease name Characteristic / Associated features Category inheritance type
TACI deficiency Chronic sinusitis; recurrent otitis media; conjunctivitis; bronchiectasis; recurrent pneumonia; hepatomegaly; splenomegaly; chronic enteritis; diarrhea; meningitis; recurrent bacterial infections; lymphadenopathy; decreased IgG level; defective antibody production; increased number of B cells; variable degree of T cell dysfunction; lymph nodes show florid reactive follicular hyperplasia and marked paracortical expansion with immunoblasts and plasma cells; autoimmune disease; lymphoma; markedly reduced IgA levels; markedly reduced IgG levels; reduced IgM levels; Abnormal immunoglobulin level; Absent specific antibody response; Defective B cell differentiation; low numbers of CD27+ memory B cells Predominantly antibody deficiencies Autosomal recessive / Autosomal dominant
TACI deficiency Recurrent sinopulmonary infections; gastrointestinal infections; autoimmune disease Predominantly antibody deficiencies -
- Bacterial infections; Opportunistic Infection; Autoimmune Disease; decreased number of pro-B cells Predominantly antibody deficiencies -