Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

TNFRSF1A

External links	Primary Information
MGI:1314884 ENSMUSG00000030341	Gene Symbol	Tnfrsf1a
	Affected Anatomical Systems	adipose tissue phenotype,cardiovascular system phenotype,cellular phenotype,digestive/alimentary phenotype,embryogenesis phenotype,endocrine/exocrine gland phenotype,growth/size phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,lethality-postnatal,lethality-prenatal/perinatal,life span-post-weaning/aging,limbs/digits/tail phenotype,liver/biliary system phenotype,nervous system phenotype,no phenotypic analysis,respiratory system phenotype,skeleton phenotype,vision/eye phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:1861040 Tnfrsf1atm1Blt Targeted (knock-out) targeted mutation 1, Horst Bluethmann 8395024 MGI:3053140 Tnfrsf1atm1Gkl Targeted (knock-out) targeted mutation 1, George Kollias 15289505 MGI:1857468 Tnfrsf1atm1Imx Targeted (knock-out) targeted mutation 1, Immunex Research and Development Corporation 9551933 MGI:1857261 Tnfrsf1atm1Mak Targeted (knock-out) targeted mutation 1, Tak Mak 8387893 MGI:3808000 Tnfrsf1atm1Rsie Targeted (knock-in) targeted mutation 1, Richard M Siegel 16684962 MGI:3686874 Tnfrsf1atm2Gkl Targeted (knock-out) targeted mutation 2, George Kollias 16413924
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Immune System Physiology Tnfrsf1atm1Imx>/Tnfrsf1a involves: 129S7/SvEvBrd * C57BL/6 9551933 Granulomatous Inflammation Tnfrsf1atm1Mak>/Tnfrsf1a involves: 129S2/SvPas * C57BL/6J * DBA/2J 10377141 Liver Inflammation Tnfrsf1atm1Gkl>/Tnfrsf1a involves: 129/Sv * C57BL/6 15289505 Decreased Susceptibility To Bacterial Infection Tnfrsf1atm1Gkl>/Tnfrsf1a involves: 129/Sv * C57BL/6 15289505 Abnormal Cytokine Secretion Tnfrsf1atm1Gkl>/Tnfrsf1a involves: 129/Sv * C57BL/6 15289505 Increased Susceptibility To Experimental Autoimmune Encephalomyelitis Tnfrsf1atm1Gkl>/Tnfrsf1a involves: 129/Sv * C57BL/6 15289505 Increased Sensitivity To Induced Morbidity/mortality Tnfrsf1atm1Gkl>/Tnfrsf1a involves: 129/Sv * C57BL/6 15289505 Liver Inflammation Tnfrsf1atm1Gkl>/Tnfrsf1a<+ involves: 129/Sv * C57BL/6 15289505 Increased Sensitivity To Induced Morbidity/mortality Tnfrsf1atm1Gkl>/Tnfrsf1a<+ involves: 129/Sv * C57BL/6 15289505 Decreased Physiological Sensitivity To Xenobiotic Tnfrsf1atm1Blt>/Tnfrsf1a C.129P2-Tnfrsf1a 14557383 Decreased Sensitivity To Xenobiotic Induced Morbidity/mortality Tnfrsf1atm1Blt>/Tnfrsf1a C.129P2-Tnfrsf1a 14557383 Abnormal Central Nervous System Regeneration Tnfrsf1atm1Blt>/Tnfrsf1a B6.129P2-Tnfrsf1a 11517251 Abnormal Immune System Physiology Tnfrsf1atm1Blt>/Tnfrsf1a involves: 129P2/OlaHsd * C57BL/6 8395024 Allergic Response Tnfrsf1atm1Blt>/Tnfrsf1a involves: 129P2/OlaHsd * C57BL/6 15366373 Increased Susceptibility To Bacterial Infection Tnfrsf1atm1Blt>/Tnfrsf1a involves: 129P2/OlaHsd * C57BL/6 8395024 Abnormal Peyer's Patch Morphology Tnfrsf1atm1Blt>/Tnfrsf1a involves: 129P2/OlaHsd * C57BL/6 9177215 Abnormal Lymph Node B Cell Domain Tnfrsf1atm1Blt>/Tnfrsf1a involves: 129P2/OlaHsd * C57BL/6 9177215 Abnormal Peyer's Patch Follicle Morphology Tnfrsf1atm1Blt>/Tnfrsf1a involves: 129P2/OlaHsd * C57BL/6 9177215 Decreased Peyer's Patch Number Tnfrsf1atm1Blt>/Tnfrsf1a involves: 129P2/OlaHsd * C57BL/6 9177215 Absent Follicular Dendritic Cells Tnfrsf1atm1Blt>/Tnfrsf1a involves: 129P2/OlaHsd * C57BL/6 9177215 Decreased Interleukin-6 Secretion Tnfrsf1atm1Blt>/Tnfrsf1a involves: 129P2/OlaHsd * C57BL/6 8395024 Decreased Susceptibility To Autoimmune Diabetes Tnfrsf1atm1Mak>/Tnfrsf1a involves: 129S2/SvPas * C57BL/6J * NOD 10946317 Decreased Inflammatory Response Tnfrsf1atm1Imx>/Tnfrsf1a C57BL/6-Tnfrsf1a 9551933 Increased Susceptibility To Bacterial Infection Tnfrsf1atm1Imx>/Tnfrsf1a C57BL/6-Tnfrsf1a 9551933 Increased Circulating Tumor Necrosis Factor Level Tnfrsf1atm1Imx>/Tnfrsf1a C57BL/6-Tnfrsf1a 9551933 Decreased Susceptibility To Endotoxin Shock Tnfrsf1atm1Imx>/Tnfrsf1a C57BL/6-Tnfrsf1a 9551933 Decreased Susceptibility To Bacterial Infection Tnfrsf1atm1Mak>/Tnfrsf1a involves: 129S2/SvPas 17353199,8387893 Abnormal Spleen Germinal Center Morphology Tnfrsf1atm1Mak>/Tnfrsf1a involves: 129S2/SvPas 18641654 Decreased IgG Level Tnfrsf1atm1Mak>/Tnfrsf1a involves: 129S2/SvPas 18641654 Increased Circulating Tumor Necrosis Factor Level Tnfrsf1atm1Mak>/Tnfrsf1a involves: 129S2/SvPas 18641654 Decreased Circulating Interleukin-6 Level Tnfrsf1atm1Mak>/Tnfrsf1a involves: 129S2/SvPas 18719121 Increased Susceptibility To Bacterial Infection Induced Morbidity/mortality Tnfrsf1atm1Mak>/Tnfrsf1a involves: 129S2/SvPas 18641654,8387893 Decreased Susceptibility To Bacterial Infection Tnfrsf1atm1Blt>/Tnfrsf1a involves: 129/Sv * 129P2/OlaHsd * C57BL/6 9820556 Decreased Circulating Alanine Transaminase Level Tnfrsf1atm1Blt>/Tnfrsf1a involves: 129/Sv * 129P2/OlaHsd * C57BL/6 9820556