mRNA IDs | Primary Information | |
NM_000043.3,NM_152871.1,NM_152872.1,NM_152873.1,NM_152874.1,NM_152875.1,NM_152876.1,NM_152877.1 | Gene Symbol | FAS |
Protein Name | Fas (tnf receptor superfamily, member 6) | |
Alternate Names | ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | |
Gene Locus | 10q24.1 |
External links | ||||||||||||||||||||||||
|
Disease name | Characteristic / Associated features | Category | inheritance type |
Autoimmune lymphoproliferative syndrome, type Ia | Hepatomegaly; Splenomegaly; Chronic noninfectious lymphadenopathy; autoimmune hemolytic anemia; cytopenia; thrombocytopenia; recurrent urticarial rashes; immune vasculitis; hypergammaglobulinemia; expansion of T lymphocyte population; Impairment of TCR-induced apoptosis; petechiae; generalized edema; Presence of autoantibodies; extramedullary hematopoiesis in liver; Abnormality of the hematopoietic system; lack of FAS expression; Absent CD4+ T cells; Absent CD8+ T cells; Increased numbers of double negative T lymphocytes (CD3+CD4 CD8 ); Increased number of B cells; increased susceptibility to hematological malignancy | Diseases of Immune Dysregulation | Autosomal dominant |