FAS
Primary Info
Mutation
Mouse studies
DNA sequencing


mRNA IDs Primary Information
NM_000043.3,NM_152871.1,NM_152872.1,NM_152873.1,NM_152874.1,NM_152875.1,NM_152876.1,NM_152877.1 Gene Symbol FAS
Protein Name Fas (tnf receptor superfamily, member 6)
Alternate Names ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Gene Locus 10q24.1

External links
IDR HPRD OMIM Entrez Gene NetPath Reactome PDB HGNC Ensembl Swiss-Prot RefDIC
36 00609 134637 355 NetPath_M355 355 1BZI
1DDF
11920 ENSG00000026103 P25445 FAS

Disease name Characteristic / Associated features Category inheritance type
Autoimmune lymphoproliferative syndrome, type Ia Hepatomegaly; Splenomegaly; Chronic noninfectious lymphadenopathy; autoimmune hemolytic anemia; cytopenia; thrombocytopenia; recurrent urticarial rashes; immune vasculitis; hypergammaglobulinemia; expansion of T lymphocyte population; Impairment of TCR-induced apoptosis; petechiae; generalized edema; Presence of autoantibodies; extramedullary hematopoiesis in liver; Abnormality of the hematopoietic system; lack of FAS expression; Absent CD4+ T cells; Absent CD8+ T cells; Increased numbers of double negative T lymphocytes (CD3+CD4 CD8 ); Increased number of B cells; increased susceptibility to hematological malignancy Diseases of Immune Dysregulation Autosomal dominant