Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

UNC13D

External links	Primary Information
MGI:1917700 ENSMUSG00000057948	Gene Symbol	Unc13d
	Affected Anatomical Systems	hematopoietic system phenotype,immune system phenotype,skeleton phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3628822 Unc13dJinx Chemically induced (ENU) Jinx 16688530
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Bone Marrow Morphology Unc13dJinx>/Unc13d C57BL/6 17420270 Increased Susceptibility To Viral Infection Unc13dJinx>/Unc13d C57BL/6 16688530,17420270 Anemia Unc13dJinx>/Unc13d C57BL/6 17420270 Enlarged Spleen Unc13dJinx>/Unc13d C57BL/6 17420270 Abnormal Macrophage Physiology Unc13dJinx>/Unc13d C57BL/6 16688530 Increased Monocyte Cell Number Unc13dJinx>/Unc13d C57BL/6 17420270 Increased Neutrophil Cell Number Unc13dJinx>/Unc13d C57BL/6 17420270 Abnormal NK Cell Physiology Unc13dJinx>/Unc13d C57BL/6 17420270 Defective Cytotoxic T Cell Cytolysis Unc13dJinx>/Unc13d C57BL/6 17420270 Abnormal Cytokine Secretion Unc13dJinx>/Unc13d C57BL/6 17420270 Decreased Platelet Cell Number Unc13dJinx>/Unc13d C57BL/6 17420270 Increased CD8-positive T Cell Number Unc13dJinx>/Unc13d C57BL/6 17420270 Absent Lymph Node Germinal Center Unc13dJinx>/Unc13d C57BL/6 17420270