Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

AIRE

External links	Primary Information
MGI:1338803 ENSMUSG00000000731	Gene Symbol	Aire
	Affected Anatomical Systems	behavior/neurological phenotype,digestive/alimentary phenotype,endocrine/exocrine gland phenotype,growth/size phenotype,hematopoietic system phenotype,immune system phenotype,life span-post-weaning/aging,liver/biliary system phenotype,nervous system phenotype,no phenotypic analysis,normal phenotype,reproductive system phenotype,respiratory system phenotype,vision/eye phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:2661910 Airetm1.1Doi Targeted (knock-out) targeted mutation 1.1, Christophe Benoist and Diane Mathis 12376594 MGI:2661909 Airetm1Doi Targeted (Floxed/Frt) targeted mutation 1, Christophe Benoist and Diane Mathis 12376594 MGI:3793464 Airetm1Mand Targeted (knock-in) targeted mutation 1, Mark S Anderson 18414681 MGI:3573749 Airetm1Mmat Targeted (knock-out) targeted mutation 1, Mitsuru Matsumoto 15699112 MGI:2182940 Airetm1Pltn Targeted (knock-out) targeted mutation 1, Leena Peltonen 11854172 MGI:3722595 Airetm1Ptsn Targeted (knock-out) targeted mutation 1, Part Peterson 17599412 MGI:3818933 Airetm2Mmat Targeted (Reporter) targeted mutation 2, Mitsuru Matsumoto 19015306
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Infertility Airetm1Pltn>/Aire involves: 129S4/SvJae * C57BL/6 11854172 Liver Inflammation Airetm1Pltn>/Aire involves: 129S4/SvJae * C57BL/6 11854172 Absent Adrenal Gland Airetm1Pltn>/Aire involves: 129S4/SvJae * C57BL/6 11854172 Increased T Cell Proliferation Airetm1Pltn>/Aire involves: 129S4/SvJae * C57BL/6 11854172 Thymus Atrophy Airetm1Pltn>/Aire involves: 129S4/SvJae * C57BL/6 11854172 Increased Autoantibody Level Airetm1Pltn>/Aire involves: 129S4/SvJae * C57BL/6 11854172 Abnormal T Cell Morphology Airetm1Pltn>/Aire involves: 129S4/SvJae * C57BL/6 11854172 Reduced Fertility Airetm1Pltn>/Aire<+ involves: 129S4/SvJae * C57BL/6 11854172 Stomach Inflammation Airetm1.1Doi>/Aire involves: 129S2/SvPas * C57BL/6 17360567 Abnormal Thymus Medulla Morphology Airetm1.1Doi>/Aire involves: 129S2/SvPas * C57BL/6 12376594 Increased T Cell Number Airetm1.1Doi>/Aire involves: 129S2/SvPas * C57BL/6 12376594 Increased Susceptibility To Autoimmune Disorder Airetm1.1Doi>/Aire involves: 129S2/SvPas * C57BL/6 12376594 Increased Autoantibody Level Airetm1.1Doi>/Aire involves: 129S2/SvPas * C57BL/6 17360567 Abnormal Lacrimal Gland Morphology Airetm1Mmat>/Aire involves: C57BL/6 * CBA 15699112 Abnormal Stomach Morphology Airetm1Mmat>/Aire involves: C57BL/6 * CBA 15699112 Reduced Fertility Airetm1Mmat>/Aire involves: C57BL/6 * CBA 15699112 Autoimmune Response Airetm1Mmat>/Aire involves: C57BL/6 * CBA 15699112 Abnormal Pancreas Morphology Airetm1Mmat>/Aire involves: C57BL/6 * CBA 15699112 Abnormal Lacrimal Gland Physiology Airetm1Mmat>/Aire involves: C57BL/6 * CBA 15699112 Abnormal Parotid Gland Morphology Airetm1Mmat>/Aire involves: C57BL/6 * CBA 15699112 Abnormal Submandibular Gland Morphology Airetm1Mmat>/Aire involves: C57BL/6 * CBA 15699112 Stomach Inflammation Airetm1Mmat>/Aire C.Cg-Aire 15699112 Abnormal Gastric Mucosa Morphology Airetm1Mmat>/Aire C.Cg-Aire 15699112 Increased Autoantibody Level Airetm1Mmat>/Aire C.Cg-Aire 15699112 Abnormal Salivary Gland Morphology Airetm1Mmat>/Aire B6.Cg-Aire 15699112 Autoimmune Response Airetm1Mmat>/Aire B6.Cg-Aire 15699112 Abnormal Immune System Morphology Airetm1Ptsn>/Aire either: (involves: BALB/c) or (involves: C57BL/6J) 17599412 Abnormal Immune System Morphology Airetm1Ptsn>/Aire<+ either: (involves: BALB/c) or (involves: C57BL/6J) 17599412 Increased Incidence Of Corneal Inflammation Airetm1.1Doi>/Aire B6.129S2-Aire/Doi 16172259 Salivary Gland Inflammation Airetm1.1Doi>/Aire B6.129S2-Aire/Doi 16172259 Stomach Inflammation Airetm1.1Doi>/Aire B6.129S2-Aire/Doi 16172259 Retinal Degeneration Airetm1.1Doi>/Aire B6.129S2-Aire/Doi 16172259 Lung Inflammation Airetm1.1Doi>/Aire B6.129S2-Aire/Doi 16172259 Increased Autoantibody Level Airetm1.1Doi>/Aire B6.129S2-Aire/Doi 16172259 Premature Death Airetm1.1Doi>/Aire NOD.129S2(B6)-Aire/Doi 16172259 Increased Incidence Of Corneal Inflammation Airetm1.1Doi>/Aire NOD.129S2(B6)-Aire/Doi 16172259 Liver Inflammation Airetm1.1Doi>/Aire NOD.129S2(B6)-Aire/Doi 16172259 Pancreas Inflammation Airetm1.1Doi>/Aire NOD.129S2(B6)-Aire/Doi 16172259 Salivary Gland Inflammation Airetm1.1Doi>/Aire NOD.129S2(B6)-Aire/Doi 16172259 Stomach Inflammation Airetm1.1Doi>/Aire NOD.129S2(B6)-Aire/Doi 16172259 Retinal Degeneration Airetm1.1Doi>/Aire NOD.129S2(B6)-Aire/Doi 16172259 Ovary Inflammation Airetm1.1Doi>/Aire NOD.129S2(B6)-Aire/Doi 16172259 Lung Inflammation Airetm1.1Doi>/Aire NOD.129S2(B6)-Aire/Doi 16172259 Cachexia Airetm1.1Doi>/Aire NOD.129S2(B6)-Aire/Doi 16172259 Thyroid Inflammation Airetm1.1Doi>/Aire NOD.129S2(B6)-Aire/Doi 16172259 Prostate Inflammation Airetm1.1Doi>/Aire NOD.129S2(B6)-Aire/Doi 16172259 Increased Autoantibody Level Airetm1.1Doi>/Aire NOD.129S2(B6)-Aire/Doi 16172259 Increased Incidence Of Corneal Inflammation Airetm1.1Doi>/Aire C.129S2-Aire/Doi 16172259 Liver Inflammation Airetm1.1Doi>/Aire C.129S2-Aire/Doi 16172259 Salivary Gland Inflammation Airetm1.1Doi>/Aire C.129S2-Aire/Doi 16172259 Stomach Inflammation Airetm1.1Doi>/Aire C.129S2-Aire/Doi 16172259 Retinal Degeneration Airetm1.1Doi>/Aire C.129S2-Aire/Doi 16172259 Ovary Inflammation Airetm1.1Doi>/Aire C.129S2-Aire/Doi 16172259 Lung Inflammation Airetm1.1Doi>/Aire C.129S2-Aire/Doi 16172259 Prostate Inflammation Airetm1.1Doi>/Aire C.129S2-Aire/Doi 16172259 Increased Autoantibody Level Airetm1.1Doi>/Aire C.129S2-Aire/Doi 16172259 Liver Inflammation Airetm1.1Doi>/Aire SJL.129S2-Aire/Doi 16172259 Pancreas Inflammation Airetm1.1Doi>/Aire SJL.129S2-Aire/Doi 16172259 Salivary Gland Inflammation Airetm1.1Doi>/Aire SJL.129S2-Aire/Doi 16172259 Stomach Inflammation Airetm1.1Doi>/Aire SJL.129S2-Aire/Doi 16172259 Ovary Inflammation Airetm1.1Doi>/Aire SJL.129S2-Aire/Doi 16172259 Lung Inflammation Airetm1.1Doi>/Aire SJL.129S2-Aire/Doi 16172259 Prostate Inflammation Airetm1.1Doi>/Aire SJL.129S2-Aire/Doi 16172259 Increased Autoantibody Level Airetm1.1Doi>/Aire SJL.129S2-Aire/Doi 16172259 Liver Inflammation Airetm1.1Doi>/Aire involves: 129S2/SvPas * C57BL/6 * NOD 16172259 Pancreas Inflammation Airetm1.1Doi>/Aire involves: 129S2/SvPas * C57BL/6 * NOD 16172259 Salivary Gland Inflammation Airetm1.1Doi>/Aire involves: 129S2/SvPas * C57BL/6 * NOD 16172259 Stomach Inflammation Airetm1.1Doi>/Aire involves: 129S2/SvPas * C57BL/6 * NOD 16172259 Lung Inflammation Airetm1.1Doi>/Aire involves: 129S2/SvPas * C57BL/6 * NOD 16172259 Salivary Gland Inflammation Airetm1Mand>/Aire<+ involves: 129P2/OlaHsd * C57BL/6 18414681 Lacrimal Gland Inflammation Airetm1Mand>/Aire<+ involves: 129P2/OlaHsd * C57BL/6 18414681 Eye Inflammation Airetm1Mand>/Aire involves: 129P2/OlaHsd * C57BL/6 18414681 Salivary Gland Inflammation Airetm1Mand>/Aire involves: 129P2/OlaHsd * C57BL/6 18414681 Lacrimal Gland Inflammation Airetm1Mand>/Aire involves: 129P2/OlaHsd * C57BL/6 18414681 Salivary Gland Inflammation Airetm1Mand>/Aire<+ NOD.129P2-Aire 18414681 Hindlimb Paralysis Airetm1Mand>/Aire<+ NOD.129P2-Aire 18414681 Abnormal Sciatic Nerve Airetm1Mand>/Aire<+ NOD.129P2-Aire 18414681 Abnormal CD4-positive T Cell Physiology Airetm1Mand>/Aire<+ NOD.129P2-Aire 18414681 CNS Inflammation Airetm1Mand>/Aire<+ NOD.129P2-Aire 18414681 Chronic Pancreas Inflammation Airetm1Mand>/Aire<+ NOD.129P2-Aire 18414681 Thyroid Inflammation Airetm1Mand>/Aire<+ NOD.129P2-Aire 18414681 Insulitis Airetm1Mand>/Aire<+ NOD.129P2-Aire 18414681 Increased Susceptibility To Autoimmune Diabetes Airetm1Mand>/Aire<+ NOD.129P2-Aire 18414681 Lacrimal Gland Inflammation Airetm1Mand>/Aire<+ NOD.129P2-Aire 18414681 Salivary Gland Inflammation Airetm1.1Doi>/Aire NOD.129S2-Aire 18414681 Stomach Inflammation Airetm1.1Doi>/Aire NOD.129S2-Aire 18414681 Lung Inflammation Airetm1.1Doi>/Aire NOD.129S2-Aire 18414681 Abnormal CD4-positive T Cell Physiology Airetm1.1Doi>/Aire NOD.129S2-Aire 18414681 Uveitis Airetm1.1Doi>/Aire NOD.129S2-Aire 18414681 Chronic Pancreas Inflammation Airetm1.1Doi>/Aire NOD.129S2-Aire 18414681 Thyroid Inflammation Airetm1.1Doi>/Aire NOD.129S2-Aire 18414681 Insulitis Airetm1.1Doi>/Aire NOD.129S2-Aire 18414681 Lacrimal Gland Inflammation Airetm1.1Doi>/Aire NOD.129S2-Aire 18414681 Weight Loss Airetm1Mand>/Aire NOD.129-Aire/Aire 18414681 Salivary Gland Inflammation Airetm1Mand>/Aire NOD.129-Aire/Aire 18414681 Stomach Inflammation Airetm1Mand>/Aire NOD.129-Aire/Aire 18414681 Lung Inflammation Airetm1Mand>/Aire NOD.129-Aire/Aire 18414681 Abnormal CD4-positive T Cell Physiology Airetm1Mand>/Aire NOD.129-Aire/Aire 18414681 Uveitis Airetm1Mand>/Aire NOD.129-Aire/Aire 18414681 Chronic Pancreas Inflammation Airetm1Mand>/Aire NOD.129-Aire/Aire 18414681 Thyroid Inflammation Airetm1Mand>/Aire NOD.129-Aire/Aire 18414681 Insulitis Airetm1Mand>/Aire NOD.129-Aire/Aire 18414681 Lacrimal Gland Inflammation Airetm1Mand>/Aire NOD.129-Aire/Aire 18414681 Abnormal Thymus Morphology Airetm2Mmat>/Aire involves: C57BL/6 * CBA 19015306 Autoimmune Response Airetm2Mmat>/Aire involves: C57BL/6 * CBA 19015306 Abnormal Thymus Physiology Airetm2Mmat>/Aire involves: C57BL/6 * CBA 19015306 Absent Hassall's Corpuscle Airetm2Mmat>/Aire involves: C57BL/6 * CBA 19015306 Abnormal Thymus Morphology Airetm1Mmat>/Aire involves: C57BL/6 * CBA 19015306 Autoimmune Response Airetm1Mmat>/Aire involves: C57BL/6 * CBA 19015306 Salivary Gland Inflammation Airetm1Ptsn>/Aire C57BL/6-Aire 19265170 Reduced Male Fertility Airetm1Ptsn>/Aire C57BL/6-Aire 19265170 Abnormal T Cell Activation Airetm1Ptsn>/Aire C57BL/6-Aire 19265170 Abnormal Thymus Medulla Morphology Airetm1Ptsn>/Aire C57BL/6-Aire 19265170 Uveitis Airetm1Ptsn>/Aire C57BL/6-Aire 19265170 Vitreous Body Inflammation Airetm1Ptsn>/Aire C57BL/6-Aire 19265170 Increased Autoantibody Level Airetm1Ptsn>/Aire C57BL/6-Aire 19265170