ICOS
Primary Info
Mutation
Mouse studies
DNA sequencing


mRNA IDs Primary Information
NM_012092.2 Gene Symbol ICOS
Protein Name Inducible t-cell co-stimulator
Alternate Names AILIM, CD278, MGC39850
Gene Locus 2q33

External links
IDR HPRD OMIM Entrez Gene NetPath Reactome PDB HGNC Ensembl Swiss-Prot RefDIC
116 09196 604558 29851 NetPath_M29851 29851 -
 5351 ENSG00000163600 Q9Y6W8 ICOS

Disease name Characteristic / Associated features Category inheritance type
ICOS deficiency Sinusitis, recurrent; Otitis media, recurrent; Conjunctivitis; Bronchiectasis; Bronchitis, recurrent; Pneumonia, recurrent episodes; Hepatomegaly; Splenomegaly; Enteritis, recurrent; Diarrhea; Recurrent bacterial infections; Herpes infections; Lymphadenopathy; Hypogammaglobulinemia; Normal or reduced numbers of B cells; Defective antibody production; Normal numbers of T cells; Variable degree of T cell dysfunction; Autoimmune neutropenia; Markedly reduced IgA levels; Markedly reduced IgG levels Predominantly antibody deficiencies Autosomal recessive