Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

BLNK

External links	Primary Information
MGI:96878 ENSMUSG00000061132	Gene Symbol	Blnk
	Affected Anatomical Systems	hematopoietic system phenotype,immune system phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:2389137 Blnktm1Achn Targeted (knock-out) targeted mutation 1, Andrew C Chan 10583957 MGI:2665856 Blnktm1Dkit Targeted (knock-out) targeted mutation 1, Daisuke Kitamura 12818163 MGI:2386672 Blnktm1Kplm Targeted (knock-out) targeted mutation 1, Kong-Peng Lam 10700474 MGI:2447161 Blnktm1Pjln Targeted (knock-out) targeted mutation 1, Peter J Nielsen 10591180
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Increased Tumor Incidence Blnktm1Pjln>/Blnk involves: BALB/c 12436112 Enlarged Spleen Blnktm1Pjln>/Blnk involves: BALB/c 12436112 Decreased IgM Level Blnktm1Pjln>/Blnk involves: BALB/c 10591180 Arrested B Cell Differentiation Blnktm1Pjln>/Blnk involves: BALB/c 10591180 Abnormal Pre-B Cell Morphology Blnktm1Pjln>/Blnk involves: BALB/c 10591180 Increased Pre-B Cell Number Blnktm1Pjln>/Blnk involves: BALB/c 10591180,12436112 Increased Mature B Cell Number Blnktm1Pjln>/Blnk involves: BALB/c 20133609 Decreased Mature B Cell Number Blnktm1Pjln>/Blnk involves: BALB/c 10591180 Decreased IgG3 Level Blnktm1Pjln>/Blnk involves: BALB/c 10591180 Abnormal B Cell Differentiation Blnktm1Dkit>/Blnk involves: C57BL/6 12818163 Leukemia Blnktm1Dkit>/Blnk involves: C57BL/6 12818163 Decreased IgM Level Blnktm1Dkit>/Blnk involves: C57BL/6 16481047 Arrested B Cell Differentiation Blnktm1Dkit>/Blnk involves: C57BL/6 16481047 Abnormal Pre-B Cell Morphology Blnktm1Dkit>/Blnk involves: C57BL/6 12818163 Abnormal Immature B Cell Morphology Blnktm1Dkit>/Blnk involves: C57BL/6 15528332 Increased Anti-double Stranded DNA Antibody Level Blnktm1Dkit>/Blnk involves: C57BL/6 15528332 Abnormal Plasma Cell Differentiation Blnktm1Dkit>/Blnk involves: C57BL/6 16481047 Decreased Follicular B Cell Number Blnktm1Dkit>/Blnk involves: C57BL/6 16481047 Decreased Marginal Zone B Cell Number Blnktm1Dkit>/Blnk involves: C57BL/6 16481047 Decreased Transitional Stage B Cell Number Blnktm1Dkit>/Blnk involves: C57BL/6 16481047 Decreased Mature B Cell Number Blnktm1Dkit>/Blnk involves: C57BL/6 12818163 Decreased Immature B Cell Number Blnktm1Dkit>/Blnk involves: C57BL/6 12818163 Decreased IgG3 Level Blnktm1Dkit>/Blnk involves: C57BL/6 16481047 Abnormal B Cell Apoptosis Blnktm1Dkit>/Blnk involves: C57BL/6 16481047 Increased B Cell Apoptosis Blnktm1Dkit>/Blnk involves: C57BL/6 16481047 Abnormal B Cell Differentiation Blnktm1Achn>/Blnk involves: 129X1/SvJ 10583957 Decreased Immunoglobulin Level Blnktm1Achn>/Blnk involves: 129X1/SvJ 10583957 Arrested B Cell Differentiation Blnktm1Achn>/Blnk involves: 129X1/SvJ 10583957 Decreased B-1a Cell Number Blnktm1Achn>/Blnk involves: 129X1/SvJ 10583957 Abnormal Mature B Cell Morphology Blnktm1Achn>/Blnk involves: 129X1/SvJ 10583957 Increased Pro-B Cell Number Blnktm1Achn>/Blnk involves: 129X1/SvJ 10583957 Absent B-1b Cells Blnktm1Achn>/Blnk involves: 129X1/SvJ 10583957 Decreased Mature B Cell Number Blnktm1Achn>/Blnk involves: 129X1/SvJ 10583957 Decreased Splenocyte Number Blnktm1Achn>/Blnk involves: 129X1/SvJ 10583957 Decreased B Cell Proliferation Blnktm1Achn>/Blnk<+ involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6 12618482 Abnormal B Cell Differentiation Blnktm1Kplm>/Blnk involves: 129P2/OlaHsd 10700474,16585562 Spleen Hypoplasia Blnktm1Kplm>/Blnk involves: 129P2/OlaHsd 16585562 Decreased B Cell Number Blnktm1Kplm>/Blnk involves: 129P2/OlaHsd 10700474,16585562 Decreased B Cell Proliferation Blnktm1Kplm>/Blnk involves: 129P2/OlaHsd 10700474 Increased Pro-B Cell Number Blnktm1Kplm>/Blnk involves: 129P2/OlaHsd 10700474,16585562 Absent B-1a Cells Blnktm1Kplm>/Blnk involves: 129P2/OlaHsd 10700474 Decreased Pre-B Cell Number Blnktm1Kplm>/Blnk involves: 129P2/OlaHsd 10700474,12119344 Decreased Mature B Cell Number Blnktm1Kplm>/Blnk involves: 129P2/OlaHsd 10700474 Decreased Immature B Cell Number Blnktm1Kplm>/Blnk involves: 129P2/OlaHsd 10700474 Abnormal B Cell Activation Blnktm1Kplm>/Blnk involves: 129P2/OlaHsd 10700474,16585562 Increased B Cell Apoptosis Blnktm1Kplm>/Blnk involves: 129P2/OlaHsd 16585562