IRAK4
Primary Info
Mutation
Mouse studies
DNA sequencing


External links Primary Information
MGI:2182474
ENSMUSG00000059883		 Gene Symbol Irak4
Affected Anatomical Systems cellular phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id
MGI:3774129 Irak4m1Btlr Chemically induced (ENU) mutation 1, Bruce Beutler
MGI:3762874 Irak4tm1Aki Targeted (knock-out) targeted mutation 1, Shizuo Akira 17485511
MGI:3712883 Irak4tm1Gram Targeted (knock-in) targeted mutation 1, Hermann Gram 17337443
MGI:3762911 Irak4tm1Lix Targeted (knock-in) targeted mutation 1, Xiaoxia Li 17470642
MGI:2676448 Irak4tm1Yeh Targeted (knock-out) targeted mutation 1, Wen-Chen Yeh 11923871
MGI:3762878 Irak4tm2Aki Targeted (knock-in) targeted mutation 1, Shizou Akira 17485511
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id
Increased Susceptibility To Bacterial Infection Irak4tm1Yeh>/Irak4 involves: 129P2/OlaHsd * C57BL/6J 11923871
Abnormal Macrophage Physiology Irak4tm1Yeh>/Irak4 involves: 129P2/OlaHsd * C57BL/6J 11923871
Abnormal NK Cell Physiology Irak4tm1Yeh>/Irak4 involves: 129P2/OlaHsd * C57BL/6J 11923871
Decreased B Cell Proliferation Irak4tm1Yeh>/Irak4 involves: 129P2/OlaHsd * C57BL/6J 11923871
Abnormal Cytokine Secretion Irak4tm1Yeh>/Irak4 involves: 129P2/OlaHsd * C57BL/6J 11923871
Decreased Circulating Tumor Necrosis Factor Level Irak4tm1Yeh>/Irak4 involves: 129P2/OlaHsd * C57BL/6J 11923871
Decreased Tumor Necrosis Factor Secretion Irak4tm1Yeh>/Irak4 involves: 129P2/OlaHsd * C57BL/6J 11923871
Decreased Circulating Interferon-gamma Level Irak4tm1Yeh>/Irak4 involves: 129P2/OlaHsd * C57BL/6J 11923871
Decreased Circulating Interleukin-1 Level Irak4tm1Yeh>/Irak4 involves: 129P2/OlaHsd * C57BL/6J 11923871
Decreased Circulating Interleukin-6 Level Irak4tm1Yeh>/Irak4 involves: 129P2/OlaHsd * C57BL/6J 11923871
Decreased Interleukin-6 Secretion Irak4tm1Yeh>/Irak4 involves: 129P2/OlaHsd * C57BL/6J 11923871
Abnormal Cytokine Level Irak4tm1Yeh>/Irak4 involves: 129P2/OlaHsd * C57BL/6J 11923871
Decreased Susceptibility To Endotoxin Shock Irak4tm1Yeh>/Irak4 involves: 129P2/OlaHsd * C57BL/6J 11923871
Abnormal Cell Physiology Irak4tm1Gram>/Irak4 involves: BALB/c 17337443
Abnormal Cytokine Secretion Irak4tm1Gram>/Irak4 involves: BALB/c 17337443
Abnormal Chemokine Secretion Irak4tm1Gram>/Irak4 involves: BALB/c 17337443
Decreased B Cell Proliferation Irak4tm1Aki>/Irak4 involves: 129X1/SvJ * C57BL/6 17485511
Abnormal Cytokine Secretion Irak4tm1Aki>/Irak4 involves: 129X1/SvJ * C57BL/6 17485511
Decreased Tumor Necrosis Factor Secretion Irak4tm1Aki>/Irak4 involves: 129X1/SvJ * C57BL/6 17485511
Decreased Interferon-alpha Secretion Irak4tm1Aki>/Irak4 involves: 129X1/SvJ * C57BL/6 17485511
Decreased Interleukin-12b Secretion Irak4tm1Aki>/Irak4 involves: 129X1/SvJ * C57BL/6 17485511
Decreased Interleukin-6 Secretion Irak4tm1Aki>/Irak4 involves: 129X1/SvJ * C57BL/6 17485511
Decreased Susceptibility To Endotoxin Shock Irak4tm1Aki>/Irak4 involves: 129X1/SvJ * C57BL/6 17485511
Decreased B Cell Proliferation Irak4tm2Aki>/Irak4 involves: 129X1/SvJ * C57BL/6 17485511
Abnormal Cytokine Secretion Irak4tm2Aki>/Irak4 involves: 129X1/SvJ * C57BL/6 17485511
Decreased Tumor Necrosis Factor Secretion Irak4tm2Aki>/Irak4 involves: 129X1/SvJ * C57BL/6 17485511
Decreased Interferon-alpha Secretion Irak4tm2Aki>/Irak4 involves: 129X1/SvJ * C57BL/6 17485511
Decreased Interleukin-12b Secretion Irak4tm2Aki>/Irak4 involves: 129X1/SvJ * C57BL/6 17485511
Decreased Interleukin-6 Secretion Irak4tm2Aki>/Irak4 involves: 129X1/SvJ * C57BL/6 17485511
Decreased Susceptibility To Endotoxin Shock Irak4tm2Aki>/Irak4 involves: 129X1/SvJ * C57BL/6 17485511
Decreased Acute Inflammation Irak4tm1Lix>/Irak4 involves: C57BL/6 17470642
Decreased Circulating Tumor Necrosis Factor Level Irak4tm1Lix>/Irak4 involves: C57BL/6 17470642
Decreased Tumor Necrosis Factor Secretion Irak4tm1Lix>/Irak4 involves: C57BL/6 17470642
Decreased Interferon-alpha Secretion Irak4tm1Lix>/Irak4 involves: C57BL/6 17470642
Decreased Interferon-beta Secretion Irak4tm1Lix>/Irak4 involves: C57BL/6 17470642
Decreased Circulating Interleukin-6 Level Irak4tm1Lix>/Irak4 involves: C57BL/6 17470642
Decreased Interleukin-6 Secretion Irak4tm1Lix>/Irak4 involves: C57BL/6 17470642
Abnormal Chemokine Secretion Irak4tm1Lix>/Irak4 involves: C57BL/6 17470642
Decreased Susceptibility To Endotoxin Shock Irak4tm1Lix>/Irak4 involves: C57BL/6 17470642
Decreased Tumor Necrosis Factor Secretion Irak4m1Btlr>/Irak4 C57BL/6J-Irak4