Resource of Asian Primary Immunodeficiency Diseases (RAPID) is a web-based compendium of molecdivar alterations in primary immunodeficiency diseases. Detailed information about genes and proteins that are affected in primary deficiency diseases is presented along with other pertinent information about protein-protein interactions, microarray gene expression profiles in various organs and cells of the immune system and mouse studies. RAPID also hosts a tool, the mutation viewer, to predict deleterious and novel mutations and also to visualize the mutation positions on the DNA sequence, protein sequence and three-dimensional structure for PID genes. The information in this database shodivd be usefdiv to researchers as well as clinicians.
In an effort to elucidate the pathogenesis of PIDs and establish methods of early diagnosis and find effective treatments, RCAI formed a collaboration in 2006 with 13 universities/colleges in Japan which belong to the research team for Investigative Research on Primary Immunodeficiency Disease Syndrome, ("Ministry of Health, Labor and Welfare Survey Research Team").
RAPID is the result of collaboration between the Institute of Bioinformatics in Bangalore, India and the Immunogenomics research group at RIKEN Research Center for Allergy and Immunology in Yokohama, Japan. This site is hosted by the Research unit for Immunoinformatics, RIKEN Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Japan. A mirror of this site is hosted at Institute of Bioinformatics in Bangalore, India.
Citing this resource
Keerthikumar, S., Raju, R., Kandasamy, K., Hijikata, A., Ramabadran, S., Balakrishnan, L., Ahmed, M., Rani, S., Selvan, L. N., Somanathan, D. S., Ray, S., Bhattacharjee, M., Gollapudi, S., Ramachandra, Y. L., Bhadra, S., Bhattacharyya, C., Imai, K., Nonoyama, S., Kanegane, H., Miyawaki, T., Pandey, A., Ohara, O. and Mohan, S. 2009. RAPID: Resource of Asian Primary Immunodeficiency Diseases. Nucleic Acids Research. 37, D863-D867. [PubMed]