Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

NBN

External links	Primary Information
MGI:1351625 ENSMUSG00000028224	Gene Symbol	Nbn
	Affected Anatomical Systems	behavior/neurological phenotype,cellular phenotype,embryogenesis phenotype,endocrine/exocrine gland phenotype,growth/size phenotype,hematopoietic system phenotype,immune system phenotype,lethality-prenatal/perinatal,life span-post-weaning/aging,nervous system phenotype,reproductive system phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3505757 Nbntm1.1Md Targeted (knock-out) targeted mutation 1.1, Martin Digweed 15333589 MGI:2183796 Nbntm1Jpt Targeted (knock-out) targeted mutation 1, John H J Petrini 11967151 MGI:3505755 Nbntm1Md Targeted (Floxed/Frt) targeted mutation 1, Martin Digweed 15333589 MGI:2156049 Nbntm1Nus Targeted (knock-out) targeted mutation 1, Andre Nussenzweig 11231126 MGI:2182645 Nbntm1Xu Targeted (knock-out) targeted mutation 1, Yang Xu 11889050 MGI:2682000 Nbntm1Zqw Targeted (knock-out) targeted mutation 1, Zhao-Qi Wang 14612522 MGI:3771078 Nbntm2.1Jpt Targeted (knock-out) targeted mutation 2.1, John H Petrini 17429352 MGI:3578646 Nbntm2.1Zqw Targeted (knock-out) targeted mutation 2.1, Zhao-Qi Wang 15821748 MGI:3531643 Nbntm2Nus Targeted (Floxed/Frt) targeted mutation 2, Andre Nussenzweig 15668392 MGI:3578645 Nbntm2Zqw Targeted (Floxed/Frt) targeted mutation 2, Zhao-Qi Wang 15821748 MGI:3831174 Nbntm3Jpt Targeted (knock-out) targeted mutation 3, John H J Petrini 19171781
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Extraembryonic Tissue Morphology Nbntm1Nus>/Nbn involves: 129 * C57BL/6 11231126 Decreased Embryo Size Nbntm1Nus>/Nbn involves: 129 * C57BL/6 11231126 Absent Extraembryonic Ectoderm Nbntm1Nus>/Nbn involves: 129 * C57BL/6 11231126 Absent Amnion Nbntm1Nus>/Nbn involves: 129 * C57BL/6 11231126 Embryonic Lethality Before Somite Formation Nbntm1Nus>/Nbn involves: 129 * C57BL/6 11231126 Disorganized Embryonic Tissue Nbntm1Nus>/Nbn involves: 129 * C57BL/6 11231126 Inner Cell Mass Degeneration Nbntm1Nus>/Nbn involves: 129 * C57BL/6 11231126 Abnormal Inner Cell Mass Proliferation Nbntm1Nus>/Nbn involves: 129 * C57BL/6 11231126 Abnormal Cell-mediated Immunity Nbntm1Xu>/Nbn Not Specified 11889050 Increased Cellular Sensitivity To Gamma-irradiation Nbntm1Xu>/Nbn Not Specified 11889050 Abnormal Ovary Morphology Nbntm1Xu>/Nbn Not Specified 11889050 Decreased Cell Proliferation Nbntm1Xu>/Nbn Not Specified 11889050 Decreased Body Weight Nbntm1Xu>/Nbn Not Specified 11889050 Increased Mortality Induced By Gamma-irradiation Nbntm1Xu>/Nbn Not Specified 11889050 Thymus Hypoplasia Nbntm1Xu>/Nbn Not Specified 11889050 Postnatal Growth Retardation Nbntm1Xu>/Nbn Not Specified 11889050 Female Infertility Nbntm1Xu>/Nbn Not Specified 11889050 Decreased T Cell Number Nbntm1Xu>/Nbn Not Specified 11889050 Absent Ovarian Follicles Nbntm1Xu>/Nbn Not Specified 11889050 Thymic Lymphoma Nbntm1Xu>/Nbn Not Specified 11889050 Abnormal Cell Cycle Nbntm1Xu>/Nbn Not Specified 11889050 Absent Oocytes Nbntm1Xu>/Nbn Not Specified 11889050 Decreased CD4-positive T Cell Number Nbntm1Xu>/Nbn Not Specified 11889050 Decreased Pre-B Cell Number Nbntm1Xu>/Nbn Not Specified 11889050 Decreased Mature B Cell Number Nbntm1Xu>/Nbn Not Specified 11889050 Abnormal Embryogenesis/ Development Nbntm1Zqw>/Nbn involves: 129S2/SvPas * C57BL/6 14612522 Increased Apoptosis Nbntm1Zqw>/Nbn involves: 129S2/SvPas * C57BL/6 14612522 Embryonic Lethality Before Somite Formation Nbntm1Zqw>/Nbn involves: 129S2/SvPas * C57BL/6 14612522 Embryonic Growth Retardation Nbntm1Zqw>/Nbn involves: 129S2/SvPas * C57BL/6 14612522 Inner Cell Mass Degeneration Nbntm1Zqw>/Nbn involves: 129S2/SvPas * C57BL/6 14612522 Mammary Adenocarcinoma Nbntm1Zqw>/Nbn<+ involves: 129S2/SvPas * C57BL/6 14612522 Increased Mortality Induced By Gamma-irradiation Nbntm1Zqw>/Nbn<+ involves: 129S2/SvPas * C57BL/6 14612522 Increased Tumor Incidence Nbntm1Zqw>/Nbn<+ involves: 129S2/SvPas * C57BL/6 14612522 Lung Adenocarcinoma Nbntm1Zqw>/Nbn<+ involves: 129S2/SvPas * C57BL/6 14612522 Lymphoma Nbntm1Zqw>/Nbn<+ involves: 129S2/SvPas * C57BL/6 14612522 B Cell Derived Lymphoma Nbntm1Zqw>/Nbn<+ involves: 129S2/SvPas * C57BL/6 14612522 T Cell Derived Lymphoma Nbntm1Zqw>/Nbn<+ involves: 129S2/SvPas * C57BL/6 14612522 Liver Adenoma Nbntm1Zqw>/Nbn<+ involves: 129S2/SvPas * C57BL/6 14612522 Thyroid Adenoma Nbntm1Zqw>/Nbn<+ involves: 129S2/SvPas * C57BL/6 14612522 Increased Incidence Of Ionizing Radiation-induced Tumors Nbntm1Zqw>/Nbn<+ involves: 129S2/SvPas * C57BL/6 14612522 Chromosomal Instability Nbntm1Zqw>/Nbn<+ involves: 129S2/SvPas * C57BL/6 14612522 Prostate Intraepithelial Neoplasia Nbntm1Zqw>/Nbn<+ involves: 129S2/SvPas * C57BL/6 14612522 Gonad Tumor Nbntm1Zqw>/Nbn<+ involves: 129S2/SvPas * C57BL/6 14612522 Liver Adenocarcinoma Nbntm1Zqw>/Nbn<+ involves: 129S2/SvPas * C57BL/6 14612522 Leydig Cell Tumor Nbntm1Zqw>/Nbn<+ involves: 129S2/SvPas * C57BL/6 14612522 Prenatal Lethality Nbntm1.1Md>/Nbn involves: 129/Sv * 129P2/OlaHsd 15333589 Increased Cellular Sensitivity To Gamma-irradiation Nbntm1Jpt>/Nbn involves: 129S7/SvEvBrd 11967151 Chromosome Breakage Nbntm1Jpt>/Nbn involves: 129S7/SvEvBrd 11967151 Abnormal Cell Cycle Checkpoint Function Nbntm1Jpt>/Nbn involves: 129S7/SvEvBrd 11967151 Decreased Cellular Sensitivity To Ionizing Radiation Nbntm2.1Jpt>/Nbn involves: 129/Sv 17429352 Decreased Cellular Sensitivity To Ionizing Radiation Nbntm3Jpt>/Nbn involves: 129/Sv 19171781