Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

NFKBIA

External links	Primary Information
MGI:104741 ENSMUSG00000021025	Gene Symbol	Nfkbia
	Affected Anatomical Systems	cellular phenotype,growth/size phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,lethality-postnatal,lethality-prenatal/perinatal,normal phenotype,skin/coat/nails phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3630257 Nfkbiatm1(Nfkbib)Brv Targeted (knock-in) targeted mutation 1, Rodrigo Bravo 9743524 MGI:3577710 Nfkbiatm1.1Kbp Targeted (knock-out) targeted mutation 1, Klaus Pfeffer 15845452 MGI:1858084 Nfkbiatm1Bal Targeted (Reporter) targeted mutation 1, David Baltimore 7590249 MGI:3654110 Nfkbiatm1Fey Targeted (knock-out) targeted mutation 1, Fiona E Yull 11067893 MGI:3577709 Nfkbiatm1Kbp Targeted (Floxed/Frt) targeted mutation 1, Klaus Pfeffer 15845452 MGI:3616190 Nfkbiatm1Stw Targeted (knock-out) targeted mutation 1, Colin Stewart 8628301
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Decreased Body Size Nfkbiatm1Bal>/Nfkbia involves: 129S4/SvJae * C57BL/6J 7590249 Postnatal Lethality Nfkbiatm1Bal>/Nfkbia involves: 129S4/SvJae * C57BL/6J 7590249 Abnormal Skin Condition Nfkbiatm1Bal>/Nfkbia involves: 129S4/SvJae * C57BL/6J 7590249 Abnormal Epidermis Stratum Basale Morphology Nfkbiatm1Bal>/Nfkbia involves: 129S4/SvJae * C57BL/6J 7590249 Flaky Skin Nfkbiatm1Bal>/Nfkbia involves: 129S4/SvJae * C57BL/6J 7590249 Scaly Skin Nfkbiatm1Bal>/Nfkbia involves: 129S4/SvJae * C57BL/6J 7590249 Increased Leukocyte Cell Number Nfkbiatm1Bal>/Nfkbia involves: 129S4/SvJae * C57BL/6J 7590249 Decreased Double-positive T Cell Number Nfkbiatm1Bal>/Nfkbia involves: 129S4/SvJae * C57BL/6J 7590249 Spleen Atrophy Nfkbiatm1Bal>/Nfkbia involves: 129S4/SvJae * C57BL/6J 7590249 Thymus Atrophy Nfkbiatm1Bal>/Nfkbia involves: 129S4/SvJae * C57BL/6J 7590249 Abnormal Granulocyte Differentiation Nfkbiatm1Bal>/Nfkbia involves: 129S4/SvJae * C57BL/6J 7590249 Postnatal Lethality Nfkbiatm1.1Kbp>/Nfkbia involves: 129P2/OlaHsd * C57BL/6 15845452 Increased Bone Marrow Cell Number Nfkbiatm1.1Kbp>/Nfkbia involves: 129P2/OlaHsd * C57BL/6 15845452 Increased Granulocyte Number Nfkbiatm1.1Kbp>/Nfkbia involves: 129P2/OlaHsd * C57BL/6 15845452 Postnatal Growth Retardation Nfkbiatm1.1Kbp>/Nfkbia involves: 129P2/OlaHsd * C57BL/6 15845452 Abnormal Granulocyte Morphology Nfkbiatm1.1Kbp>/Nfkbia involves: 129P2/OlaHsd * C57BL/6 15845452 Abnormal Erythropoiesis Nfkbiatm1.1Kbp>/Nfkbia involves: 129P2/OlaHsd * C57BL/6 15845452 No Abnormal Phenotype Detected Nfkbiatm1(Nfkbib)Brv>/Nfkbia involves: 129S1/Sv * ICR 9743524 Decreased Body Size Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Postnatal Lethality Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Abnormal Humoral Immune Response Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Reddish Skin Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Decreased Body Weight Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Scaly Skin Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Abnormal B Cell Differentiation Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Anemia Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Small Spleen Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Decreased Thymocyte Number Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Increased IgA Level Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Increased IgE Level Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Increased IgG Level Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Abnormal Cell Differentiation Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Decreased T Cell Proliferation Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Decreased Double-negative T Cell Number Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Increased B Cell Proliferation Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Abnormal Cell Physiology Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Thymus Atrophy Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Dry Skin Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Increased Single-positive T Cell Number Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Absent Spleen Germinal Center Nfkbiatm1Fey>/Nfkbia involves: 129S6/SvEvTac * C57BL/6 11067893 Postnatal Lethality Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Abnormal Myelopoiesis Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Decreased Body Weight Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Abnormal Epidermis Stratum Corneum Morphology Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Abnormal Epidermis Stratum Granulosum Morphology Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Dermatitis Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Flaky Skin Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Spontaneous Skin Ulceration Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Postnatal Growth Retardation Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Hyperkeratosis Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Abnormal Macrophage Physiology Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Acanthosis Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Increased Monocyte Cell Number Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Abnormal Erythropoiesis Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Extramedullary Hematopoiesis Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Abnormal Keratinocyte Morphology Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Increased Macrophage Cell Number Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Dry Skin Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301 Abnormal Tumor Necrosis Factor Level Nfkbiatm1Stw>/Nfkbia involves: 129S1/Sv 8628301