Resource of Asian Primary Immunodeficiency Diseases

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NHEJ1

External links	Primary Information
MGI:1922820 ENSMUSG00000026162	Gene Symbol	Nhej1
	Affected Anatomical Systems	cellular phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3809930 Nhej1tm1Fwa Targeted (knock-out) targeted mutation 1, Frederick W Alt 18775323
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Increased Cellular Sensitivity To Gamma-irradiation Nhej1tm1Fwa>/Nhej1 129S6/SvEvTac-Nhej1 17360556 Spontaneous Chromosome Breakage Nhej1tm1Fwa>/Nhej1 129S6/SvEvTac-Nhej1 17360556 Abnormal DNA Repair Nhej1tm1Fwa>/Nhej1 129S6/SvEvTac-Nhej1 17360556 Increased Cellular Sensitivity To Gamma-irradiation Nhej1tm1Fwa>/Nhej1 involves: 129/Sv 18775323 Thymus Hypoplasia Nhej1tm1Fwa>/Nhej1 involves: 129/Sv 18775323 Spleen Hypoplasia Nhej1tm1Fwa>/Nhej1 involves: 129/Sv 18775323 Increased IgM Level Nhej1tm1Fwa>/Nhej1 involves: 129/Sv 18775323 Spontaneous Chromosome Breakage Nhej1tm1Fwa>/Nhej1 involves: 129/Sv 18775323 Abnormal Class Switch Recombination Nhej1tm1Fwa>/Nhej1 involves: 129/Sv 18775323 Decreased IgG1 Level Nhej1tm1Fwa>/Nhej1 involves: 129/Sv 18775323 Decreased IgG3 Level Nhej1tm1Fwa>/Nhej1 involves: 129/Sv 18775323