Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

PRF1

External links	Primary Information
MGI:97551 ENSMUSG00000037202	Gene Symbol	Prf1
	Affected Anatomical Systems	behavior/neurological phenotype,digestive/alimentary phenotype,endocrine/exocrine gland phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,life span-post-weaning/aging,nervous system phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:2158403 Prf1tm1Clrk Targeted (knock-out) targeted mutation 1, William R Clark 7526382 MGI:3829709 Prf1tm1Geno Targeted (Reporter) targeted mutation 1, Genoway 19084435 MGI:1857235 Prf1tm1Sdz Targeted (knock-out) targeted mutation 1, Sandoz Pharmaceutical 8164737 MGI:2158418 Prf1tm1Tsc Targeted (knock-out) targeted mutation 1, Jurg Tschopp 7972104
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Increased Susceptibility To Viral Infection Prf1tm1Clrk>/Prf1 involves: 129S7/SvEvBrd * C57BL/6 7526382 Defective Cytotoxic T Cell Cytolysis Prf1tm1Clrk>/Prf1 involves: 129S7/SvEvBrd * C57BL/6 7526382 Increased Susceptibility To Viral Infection Prf1tm1Clrk>/Prf1 C.129S7(B6)-Prf1 11559824 Increased Activated T Cell Number Prf1tm1Clrk>/Prf1 C.129S7(B6)-Prf1 11559824 Abnormal Cytokine Secretion Prf1tm1Clrk>/Prf1 C.129S7(B6)-Prf1 11559824 Increased Tumor Necrosis Factor Secretion Prf1tm1Clrk>/Prf1 C.129S7(B6)-Prf1 11559824 Increased Interferon-gamma Secretion Prf1tm1Clrk>/Prf1 C.129S7(B6)-Prf1 11559824 Abnormal Inflammatory Response Prf1tm1Sdz>/Prf1 C57BL/6-Prf1 8164737 Abnormal Leukocyte Physiology Prf1tm1Sdz>/Prf1 C57BL/6-Prf1 8164737 Increased Susceptibility To Infection Prf1tm1Sdz>/Prf1 C57BL/6-Prf1 8164737 Increased Susceptibility To Bacterial Infection Prf1tm1Sdz>/Prf1 C57BL/6-Prf1 17562770 Increased Susceptibility To Viral Infection Prf1tm1Sdz>/Prf1 C57BL/6-Prf1 8164737 Increased Susceptibility To Parasitic Infection Prf1tm1Sdz>/Prf1 C57BL/6-Prf1 12594834 Abnormal NK Cell Physiology Prf1tm1Sdz>/Prf1 C57BL/6-Prf1 16116214 Impaired NK Cell Cytolysis Prf1tm1Sdz>/Prf1 C57BL/6-Prf1 8164737 Defective Cytotoxic T Cell Cytolysis Prf1tm1Sdz>/Prf1 C57BL/6-Prf1 8164737 Increased Interleukin-10 Secretion Prf1tm1Sdz>/Prf1 C57BL/6-Prf1 17562770 Increased Sensitivity To Induced Morbidity/mortality Prf1tm1Sdz>/Prf1 C57BL/6-Prf1 16116214 Decreased Susceptibility To Autoimmune Diabetes Prf1tm1Clrk>/Prf1 involves: 129S7/SvEvBrd * BALB/c * NOD 10946317 Abnormal Circulating Glucose Level Prf1tm1Sdz>/Prf1 NOD.B6-Prf1 9314549 Periinsulitis Prf1tm1Sdz>/Prf1 NOD.B6-Prf1 9314549 Decreased Pancreatic Beta Cell Number Prf1tm1Sdz>/Prf1 NOD.B6-Prf1 9314549 Insulitis Prf1tm1Sdz>/Prf1 NOD.B6-Prf1 9314549 Decreased Susceptibility To Autoimmune Diabetes Prf1tm1Sdz>/Prf1 NOD.B6-Prf1 9314549 Increased Physiological Sensitivity To Xenobiotic Prf1tm1Sdz>/Prf1 NOD.B6-Prf1 9314549 Periinsulitis Prf1tm1Sdz>/Prf1<+ NOD.B6-Prf1 9314549 Insulitis Prf1tm1Sdz>/Prf1<+ NOD.B6-Prf1 9314549 Decreased Susceptibility To Autoimmune Diabetes Prf1tm1Sdz>/Prf1<+ NOD.B6-Prf1 9314549 Brain Inflammation Prf1tm1Sdz>/Prf1 C57BL/6-Prf1/J 9736651 Increased Susceptibility To Viral Infection Prf1tm1Sdz>/Prf1 C57BL/6-Prf1/J 9736651 Demyelination Prf1tm1Sdz>/Prf1 C57BL/6-Prf1/J 9736651 CNS Inflammation Prf1tm1Sdz>/Prf1 C57BL/6-Prf1/J 9736651 Abnormal Lymphocyte Physiology Prf1tm1Sdz>/Prf1 C57BL/6-Prf1/J 9736651 Abnormal Behavior Prf1tm1Sdz>/Prf1 C57BL/6-Prf1/J 9736651 No Abnormal Phenotype Detected Prf1tm1Geno>/Prf1 involves: C57BL/6 19084435 Decreased Susceptibility To Bacterial Infection Prf1tm1Tsc>/Prf1 involves: 129S2/SvPas 9820556 Impaired NK Cell Cytolysis Prf1tm1Tsc>/Prf1 involves: 129S2/SvPas 7972104 Defective Cytotoxic T Cell Cytolysis Prf1tm1Tsc>/Prf1 involves: 129S2/SvPas 7972104 Decreased Circulating Alanine Transaminase Level Prf1tm1Tsc>/Prf1 involves: 129S2/SvPas 9820556 Impaired NK Cell Cytolysis Prf1tm1Tsc>/Prf1<+ involves: 129S2/SvPas 7972104 Defective Cytotoxic T Cell Cytolysis Prf1tm1Tsc>/Prf1<+ involves: 129S2/SvPas 7972104 Abnormal NK Cell Physiology Prf1tm1Tsc>/Prf1 129X1.129S2-Prf1 17919943 Increased Tumor Growth/size Prf1tm1Tsc>/Prf1 129X1.129S2-Prf1 17919943 Decreased T Cell Apoptosis Prf1tm1Tsc>/Prf1 129X1.129S2-Prf1 17919943 Increased Sensitivity To Induced Morbidity/mortality Prf1tm1Tsc>/Prf1 129X1.129S2-Prf1 17919943 Impaired NK Cell Cytolysis Prf1tm1Sdz>/Prf1 involves: BALB/c * C57BL/6 11801676