Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

PTPRC

External links	Primary Information
MGI:97810 ENSMUSG00000026395	Gene Symbol	Ptprc
	Affected Anatomical Systems	digestive/alimentary phenotype,growth/size phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,lethality-postnatal,life span-post-weaning/aging,liver/biliary system phenotype,normal phenotype,renal/urinary system phenotype,respiratory system phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3611894 Ptprcloc Chemically induced (ENU) lochy MGI:4355241 Ptprcm1Btlr Chemically induced (ENU) mutation 1, Bruce Beutler MGI:1857277 Ptprctm1Holm Targeted (knock-out) targeted mutation 1, Nick Holmes 8666928 MGI:2181288 Ptprctm1Mak Targeted (knock-out) targeted mutation 1, Tak W Mak 8334701 MGI:3579087 Ptprctm1Tyb Targeted (knock-out) targeted mutation 1, Victor L J Tybulewicz 10508267 MGI:3027340 Ptprctm1Weis Targeted (knock-in) targeted mutation 1, Arthur Weiss 11163182
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Lymphopoiesis Ptprctm1Holm>/Ptprc involves: 129/Sv * C57BL/6 8666928 Abnormal T Cell Differentiation Ptprctm1Holm>/Ptprc involves: 129/Sv * C57BL/6 8666928 Spleen Hyperplasia Ptprctm1Holm>/Ptprc involves: 129/Sv * C57BL/6 8666928 Abnormal B Cell Number Ptprctm1Holm>/Ptprc involves: 129/Sv * C57BL/6 8666928 Decreased Thymocyte Number Ptprctm1Holm>/Ptprc involves: 129/Sv * C57BL/6 8666928 Decreased T Cell Number Ptprctm1Holm>/Ptprc involves: 129/Sv * C57BL/6 8666928 Increased Double-negative T Cell Number Ptprctm1Holm>/Ptprc involves: 129/Sv * C57BL/6 8666928 Decreased Double-positive T Cell Number Ptprctm1Holm>/Ptprc involves: 129/Sv * C57BL/6 8666928 Decreased CD4-positive T Cell Number Ptprctm1Holm>/Ptprc involves: 129/Sv * C57BL/6 8666928 Decreased CD8-positive T Cell Number Ptprctm1Holm>/Ptprc involves: 129/Sv * C57BL/6 8666928 No Abnormal Phenotype Detected Ptprctm1Tyb>/Ptprc involves: 129S2/SvPas * C57BL/6 * DBA/2 10508267 Diarrhea Ptprctm1Tyb>/Ptprc 129S2/SvPas-Ptprc 10508267 Lethality At Weaning Ptprctm1Tyb>/Ptprc 129S2/SvPas-Ptprc 10508267 Thymus Hypoplasia Ptprctm1Tyb>/Ptprc C.129S2-Ptprc 10508267 Abnormal T Cell Physiology Ptprctm1Tyb>/Ptprc C.129S2-Ptprc 10508267 Abnormal T Cell Differentiation Ptprctm1Tyb>/Ptprc C.129S2-Ptprc 10508267 Enlarged Spleen Ptprctm1Tyb>/Ptprc C.129S2-Ptprc 10508267 Increased Double-negative T Cell Number Ptprctm1Tyb>/Ptprc C.129S2-Ptprc 10508267 Decreased Double-positive T Cell Number Ptprctm1Tyb>/Ptprc C.129S2-Ptprc 10508267 Abnormal Positive T Cell Selection Ptprctm1Tyb>/Ptprc C.129S2-Ptprc 10508267 Decreased CD4-positive T Cell Number Ptprctm1Tyb>/Ptprc C.129S2-Ptprc 10508267 Decreased CD8-positive T Cell Number Ptprctm1Tyb>/Ptprc C.129S2-Ptprc 10508267 Abnormal NK Cell Physiology Ptprctm1Tyb>/Ptprc B6.129S2-Ptprc 15867094 Abnormal Cytokine Secretion Ptprctm1Tyb>/Ptprc B6.129S2-Ptprc 15867094 Increased NK Cell Number Ptprctm1Tyb>/Ptprc B6.129S2-Ptprc 15867094 Abnormal Chemokine Secretion Ptprctm1Tyb>/Ptprc B6.129S2-Ptprc 15867094 Abnormal B Cell Number Ptprcloc>/Ptprc C57BL/6Apb-Ptprc/Apb Arrested T Cell Differentiation Ptprcloc>/Ptprc C57BL/6Apb-Ptprc/Apb Abnormal Double-positive T Cell Morphology Ptprcloc>/Ptprc C57BL/6Apb-Ptprc/Apb Decreased T Cell Number Ptprcloc>/Ptprc C57BL/6Apb-Ptprc/Apb Decreased Double-positive T Cell Number Ptprcloc>/Ptprc C57BL/6Apb-Ptprc/Apb Abnormal Thymocyte Activation Ptprcloc>/Ptprc C57BL/6Apb-Ptprc/Apb Abnormal T Cell Selection Ptprcloc>/Ptprc C57BL/6Apb-Ptprc/Apb Abnormal T Cell Morphology Ptprcloc>/Ptprc C57BL/6Apb-Ptprc/Apb Abnormal Memory T Cell Number Ptprcloc>/Ptprc C57BL/6Apb-Ptprc/Apb Decreased CD4-positive T Cell Number Ptprcloc>/Ptprc C57BL/6Apb-Ptprc/Apb Decreased CD8-positive T Cell Number Ptprcloc>/Ptprc C57BL/6Apb-Ptprc/Apb Premature Death Ptprctm1Weis>/Ptprc<+ involves: 129X1/SvJ * C57BL/6 11163182 Increased Susceptibility To Autoimmune Disorder Ptprctm1Weis>/Ptprc<+ involves: 129X1/SvJ * C57BL/6 11163182 Increased Protein Excretion Ptprctm1Weis>/Ptprc<+ involves: 129X1/SvJ * C57BL/6 11163182 Increased Anti-double Stranded DNA Antibody Level Ptprctm1Weis>/Ptprc<+ involves: 129X1/SvJ * C57BL/6 11163182 Increased IgG2a Level Ptprctm1Weis>/Ptprc<+ involves: 129X1/SvJ * C57BL/6 11163182 Premature Death Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Abnormal Digestion Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Abnormal Leukocyte Cell Number Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Enlarged Lymph Nodes Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Enlarged Spleen Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Abnormal T Cell Activation Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Abnormal Erythropoiesis Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Extramedullary Hematopoiesis Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Increased IgA Level Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Increased B Cell Number Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Increased T Cell Number Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Abnormal Immune System Organ Morphology Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Glomerulonephritis Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Increased Susceptibility To Autoimmune Disorder Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Increased Protein Excretion Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Kidney Failure Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Decreased Urine Output Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Increased Anti-double Stranded DNA Antibody Level Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Lymph Node Hyperplasia Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Abnormal Granulocyte Differentiation Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Abnormal B Cell Activation Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Increased Spleen Red Pulp Amount Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Increased Spleen White Pulp Amount Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Increased IgG2a Level Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Increased Plasmacytoid Dendritic Cell Number Ptprctm1Weis>/Ptprc involves: 129X1/SvJ * C57BL/6 11163182 Liver Inflammation Ptprctm1Weis>/Ptprc B6.129X1-Ptprc 19299707 Enlarged Lymph Nodes Ptprctm1Weis>/Ptprc B6.129X1-Ptprc 19299707 Abnormal T Cell Activation Ptprctm1Weis>/Ptprc B6.129X1-Ptprc 19299707 Lung Inflammation Ptprctm1Weis>/Ptprc B6.129X1-Ptprc 19299707 Abnormal Double-positive T Cell Morphology Ptprctm1Weis>/Ptprc B6.129X1-Ptprc 19299707 Abnormal Thymocyte Activation Ptprctm1Weis>/Ptprc B6.129X1-Ptprc 19299707 Abnormal T Cell Subpopulation Ratio Ptprctm1Weis>/Ptprc B6.129X1-Ptprc 19299707 Increased Memory T Cell Number Ptprctm1Weis>/Ptprc B6.129X1-Ptprc 19299707 Increased Plasma Cell Number Ptprctm1Weis>/Ptprc B6.129X1-Ptprc 19299707 Decreased Follicular B Cell Number Ptprctm1Weis>/Ptprc B6.129X1-Ptprc 19299707 Increased Transitional Stage B Cell Number Ptprctm1Weis>/Ptprc B6.129X1-Ptprc 19299707 Abnormal Follicular B Cell Physiology Ptprctm1Weis>/Ptprc B6.129X1-Ptprc 19299707 Abnormal B Cell Activation Ptprctm1Weis>/Ptprc B6.129X1-Ptprc 19299707 Absent T Cells Ptprcm1Btlr>/Ptprc involves: C57BL/6J