Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

RAG2

External links	Primary Information
MGI:97849 ENSMUSG00000032864	Gene Symbol	Rag2
	Affected Anatomical Systems	behavior/neurological phenotype,cardiovascular system phenotype,digestive/alimentary phenotype,endocrine/exocrine gland phenotype,growth/size phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,life span-post-weaning/aging,liver/biliary system phenotype,normal phenotype,reproductive system phenotype,skeleton phenotype,skin/coat/nails phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3720345 Rag1/Rag2tm1Mnz Targeted (other) targeted mutation 1, Michel C Nussenzweig 15021880 MGI:2654909 Rag2tm1.1Cgn Targeted (knock-out) targeted mutation 1.1, University of Cologne 11602643 MGI:3713766 Rag2tm1Avla Targeted (knock-in) targeted mutation 1, Anna Villa 17476358 MGI:2654906 Rag2tm1Cgn Targeted (Floxed/Frt) targeted mutation 1, University of Cologne 11602643 MGI:1858556 Rag2tm1Fwa Targeted (knock-out) targeted mutation 1, Frederick W Alt 1547487 MGI:3700748 Rag2tm1Libo Targeted (knock-out) targeted mutation 1, Lisa Borghesi 12871643 MGI:2450735 Rag2tm1Mao Targeted (knock-in) targeted mutation 1, Marjorie A Oettinger 12531919 MGI:3687306 Rag2tm1Tgi Targeted (Reporter) targeted mutation 1, Masaru Taniguchi 12618483 MGI:3623131 Rag2tm2Fwa Targeted (Reporter) targeted mutation 2, Frederick W Alt 10485655
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Decreased Body Size Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * MF1 1547487 Thymus Hypoplasia Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * MF1 1547487 Abnormal B Cell Differentiation Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * MF1 1547487 Abnormal T Cell Differentiation Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * MF1 1547487 Spleen Hypoplasia Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * MF1 1547487 Abnormal Immune System Cell Morphology Rag2tm1Mao>/Rag2 involves: 129S6/SvEvTac * C57BL/6 12531919 No Abnormal Phenotype Detected Rag2tm1Cgn>/Rag2 C57BL/6 11602643 Arrested B Cell Differentiation Rag2tm1.1Cgn>/Rag2 C57BL/6-Rag2 11602643 Arrested T Cell Differentiation Rag2tm1.1Cgn>/Rag2 C57BL/6-Rag2 11602643 Increased Susceptibility To Bacterial Infection Rag2tm1Fwa>/Rag2 involves: 129S/SvEv 17082625 Abnormal Macrophage Physiology Rag2tm1Fwa>/Rag2 involves: 129S/SvEv 17082625 Lung Inflammation Rag2tm1Fwa>/Rag2 involves: 129S/SvEv 17082625 Decreased Thymocyte Number Rag2tm1Fwa>/Rag2 involves: 129S/SvEv 10523604 Colitis Rag2tm1Fwa>/Rag2 involves: 129S/SvEv 17081782 Abnormal T-helper 1 Physiology Rag2tm1Fwa>/Rag2 involves: 129S/SvEv 17081782 Abnormal Response To Transplant Rag2tm1Fwa>/Rag2 involves: 129S/SvEv 17081782 Abnormal Interferon Secretion Rag2tm1Fwa>/Rag2 involves: 129S/SvEv 17082625 Abnormal Chemokine Secretion Rag2tm1Fwa>/Rag2 involves: 129S/SvEv 17082625 Decreased Susceptibility To Bacterial Infection Induced Morbidity/mortality Rag2tm1Fwa>/Rag2 involves: 129S/SvEv 17082625 Abnormal Intestinal Mucosa Morphology Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 10982764 Arrested T Cell Differentiation Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 15197172 Decreased Susceptibility To Parasitic Infection Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 9164958 Decreased Double-negative T Cell Number Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 11751756,15197172 Increased Double-negative T Cell Number Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 15197172 Abnormal Gastric Mucosa Morphology Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 10982764 Abnormal B Cell Morphology Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 11751756 Abnormal Peyer's Patch Morphology Rag2tm1Tgi>/Rag2 involves: 129S1/Sv * 129X1/SvJ 12618483 Decreased Thymocyte Number Rag2tm1Tgi>/Rag2 involves: 129S1/Sv * 129X1/SvJ 12618483 Arrested B Cell Differentiation Rag2tm1Tgi>/Rag2 involves: 129S1/Sv * 129X1/SvJ 12618483 Arrested T Cell Differentiation Rag2tm1Tgi>/Rag2 involves: 129S1/Sv * 129X1/SvJ 12618483 Decreased B Cell Number Rag2tm1Tgi>/Rag2 involves: 129S1/Sv * 129X1/SvJ 12618483 Decreased Double-positive T Cell Number Rag2tm1Tgi>/Rag2 involves: 129S1/Sv * 129X1/SvJ 12618483 Abnormal B Cell Physiology Rag2tm1Libo>/Rag2 involves: 129S6/SvEvTac * C57BL/6 * FVB/N 12871643 Decreased Bone Marrow Cell Number Rag2tm1Libo>/Rag2 involves: 129S6/SvEvTac * C57BL/6 * FVB/N 12871643 Abnormal B Cell Differentiation Rag2tm1Libo>/Rag2 involves: 129S6/SvEvTac * C57BL/6 * FVB/N 12871643 Decreased Monocyte Cell Number Rag2tm1Libo>/Rag2 involves: 129S6/SvEvTac * C57BL/6 * FVB/N 12871643 Decreased B Cell Number Rag2tm1Libo>/Rag2 involves: 129S6/SvEvTac * C57BL/6 * FVB/N 12871643 Decreased Pre-B Cell Number Rag2tm1Libo>/Rag2 involves: 129S6/SvEvTac * C57BL/6 * FVB/N 12871643 No Abnormal Phenotype Detected Rag2tm2Fwa>/Rag2 involves: 129S6/SvEvTac 10485655 Abnormal Digestive System Morphology Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Abnormal Lymph Node Morphology Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Abnormal Spleen Morphology Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Abnormal Immune System Cell Morphology Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Abnormal B Cell Physiology Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Alopecia Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Abnormal Thymus Morphology Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Small Lymph Nodes Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Small Spleen Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Decreased IgA Level Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Decreased IgG Level Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Arrested B Cell Differentiation Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Arrested T Cell Differentiation Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Decreased Lymphocyte Cell Number Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Abnormal Immune System Organ Morphology Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Decreased T Cell Proliferation Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Decreased Double-positive T Cell Number Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Cachexia Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Colitis Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Absent Peyer's Patches Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Erythroderma Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Abnormal Lymphocyte Physiology Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Decreased NK T Cell Number Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Decreased Spleen White Pulp Amount Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Absent Hassall's Corpuscle Rag2tm1Avla>/Rag2 involves: 129/Sv * C57BL/6 17476358 Abnormal Double-negative T Cell Morphology Rag1/Rag2tm1Mnz>/Rag1/Rag2 involves: 129P2/OlaHsd * C57BL/6 15021880 Abnormal Double-positive T Cell Morphology Rag1/Rag2tm1Mnz>/Rag1/Rag2 involves: 129P2/OlaHsd * C57BL/6 15021880 Decreased T Cell Number Rag1/Rag2tm1Mnz>/Rag1/Rag2 involves: 129P2/OlaHsd * C57BL/6 15021880 Abnormal T Cell Morphology Rag1/Rag2tm1Mnz>/Rag1/Rag2 involves: 129P2/OlaHsd * C57BL/6 15021880 Abnormal Intestinal Epithelium Morphology Rag2tm1Fwa>/Rag2 either: (involves: 129S/SvEv * BALB/c) or (involves: 129S/SvEv * C57BL/6) 11884426 Thymus Hypoplasia Rag2tm1Mao>/Rag2 involves: 129 * C57BL/6 12531919 Abnormal B Cell Number Rag2tm1Mao>/Rag2 involves: 129 * C57BL/6 12531919 Arrested B Cell Differentiation Rag2tm1Mao>/Rag2 involves: 129 * C57BL/6 12531919 Arrested T Cell Differentiation Rag2tm1Mao>/Rag2 involves: 129 * C57BL/6 12531919 Decreased Double-negative T Cell Number Rag2tm1Mao>/Rag2 involves: 129 * C57BL/6 12531919 Decreased Pre-B Cell Number Rag2tm1Mao>/Rag2 involves: 129 * C57BL/6 12531919 Decreased Mature B Cell Number Rag2tm1Mao>/Rag2 involves: 129 * C57BL/6 12531919 Increased Immature B Cell Number Rag2tm1Mao>/Rag2 involves: 129 * C57BL/6 12531919 Decreased Immature B Cell Number Rag2tm1Mao>/Rag2 involves: 129 * C57BL/6 12531919 Abnormal Gamma-delta T Cell Differentiation Rag2tm1Mao>/Rag2 involves: 129 * C57BL/6 12531919 Thymus Hypoplasia Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 12531919 Abnormal B Cell Number Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 12531919 Arrested B Cell Differentiation Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 12531919 Arrested T Cell Differentiation Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 12531919 Decreased Double-negative T Cell Number Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 12531919 Decreased Pre-B Cell Number Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 12531919 Decreased Mature B Cell Number Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 12531919 Increased Immature B Cell Number Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 12531919 Decreased Immature B Cell Number Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 12531919 Abnormal Gamma-delta T Cell Differentiation Rag2tm1Fwa>/Rag2 involves: 129S/SvEv * C57BL/6 12531919