Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

STAT3

External links	Primary Information
MGI:103038 ENSMUSG00000004040	Gene Symbol	Stat3
	Affected Anatomical Systems	adipose tissue phenotype,behavior/neurological phenotype,cellular phenotype,digestive/alimentary phenotype,embryogenesis phenotype,endocrine/exocrine gland phenotype,growth/size phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,lethality-postnatal,lethality-prenatal/perinatal,life span-post-weaning/aging,liver/biliary system phenotype,normal phenotype,other phenotype,reproductive system phenotype,skin/coat/nails phenotype,tumorigenesis,vision/eye phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3768533 Stat3tm1.1Xyfu Targeted (knock-out) targeted mutation 1.1, Xin-Yuan Fu 17660847 MGI:1926814 Stat3tm1Aki Targeted (knock-out) targeted mutation 1, Shizuo Akira 9108058 MGI:2673309 Stat3tm1Desi Targeted (knock-out) targeted mutation 1, Stephen Desiderio 11853668 MGI:2384272 Stat3tm1Dlv Targeted (Floxed/Frt) targeted mutation 1, David E Levy 12150892 MGI:3028651 Stat3tm1Dnl Targeted (knock-in) targeted mutation 1, James E Darnell 14673173 MGI:2451328 Stat3tm1Flv Targeted (Floxed/Frt) targeted mutation 1, Richard A Flavell 12571365 MGI:3795149 Stat3tm1Jbha Targeted (Floxed/Frt) targeted mutation 1, Joyce B Harp 18096662 MGI:2384507 Stat3tm1Vpo Targeted (Floxed/Frt) targeted mutation 1, Valeria Poli 11238899 MGI:3768531 Stat3tm1Xyfu Targeted (Floxed/Frt) targeted mutation 1, Xin-Yuan Fu 17660847 MGI:1926816 Stat3tm2Aki Targeted (Floxed/Frt) targeted mutation 2, Shizuo Akira 9794394 MGI:3040152 Stat3tm2Vpo Targeted (knock-out) targeted mutation 2, Valeria Poli 15021879 MGI:3040161 Stat3tm3Vpo Targeted (knock-out) targeted mutation 3, Valeria Poli 15021879
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Failure To Gastrulate Stat3tm1Aki>/Stat3 involves: 129P2/OlaHsd 9108058 Decreased Embryo Size Stat3tm1Aki>/Stat3 involves: 129P2/OlaHsd 9108058 Absent Mesoderm Stat3tm1Aki>/Stat3 involves: 129P2/OlaHsd 9108058 Abnormal Inner Cell Mass Stat3tm1Aki>/Stat3 involves: 129P2/OlaHsd 9108058 Embryonic Lethality Before Somite Formation Stat3tm1Aki>/Stat3 involves: 129P2/OlaHsd 9108058 Increased Susceptibility To Endotoxin Shock Stat3tm1Desi>/Stat3 involves: 129X1/SvJ 11853668 No Abnormal Phenotype Detected Stat3tm1Dnl>/Stat3 involves: C57BL/6 14673173 Decreased Body Size Stat3tm1Dnl>/Stat3 involves: C57BL/6 14673173 Postnatal Lethality Stat3tm1Dnl>/Stat3 involves: C57BL/6 14673173 Abnormal Apoptosis Stat3tm1Dnl>/Stat3 involves: C57BL/6 14673173 Decreased Body Weight Stat3tm1Dnl>/Stat3 involves: C57BL/6 14673173 Postnatal Growth Retardation Stat3tm1Dnl>/Stat3 involves: C57BL/6 14673173 Decreased Thymocyte Number Stat3tm1Dnl>/Stat3 involves: C57BL/6 14673173 Perinatal Lethality Stat3tm2Vpo>/Stat3 involves: C57BL/6 * CBA * BALB/cAn 15021879 Abnormal Macrophage Physiology Stat3tm3Vpo>/Stat3 involves: C57BL/6 * CBA * BALB/cAn 15021879 Abnormal Response To Infection Stat3tm2Aki>/Stat3 involves: 129P2/OlaHsd * BALB/c * C57BL/6 17353274 Increased Sensitivity To Induced Morbidity/mortality Stat3tm1Xyfu>/Stat3<+ involves: 129S1/Sv * C57BL/6 17660847