ORAI1
Primary Info
Mutation
Mouse studies
DNA sequencing


External links Primary Information
MGI:1925542
ENSMUSG00000049686		 Gene Symbol Orai1
Affected Anatomical Systems cardiovascular system phenotype,cellular phenotype,growth/size phenotype,hematopoietic system phenotype,immune system phenotype,lethality-prenatal/perinatal,life span-post-weaning/aging,skin/coat/nails phenotype,touch/vibrissae phenotype,vision/eye phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id
MGI:3772453 Orai1Gt(XL922)Byg Gene trapped gene trap XL922, BayGenomics 18059270
MGI:3832514 Orai1tm1Fesk Targeted (knock-in) targeted mutation 1, Stefan Feske 18952890
MGI:3810487 Orai1tm1Rao Targeted (knock-out) targeted mutation 1, Anjana Rao 18591248
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id
Decreased Body Size Orai1Gt(XL922)Byg>/Orai1 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 18059270
Abnormal Mast Cell Physiology Orai1Gt(XL922)Byg>/Orai1 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 18059270
Decreased Susceptibility To Type I Hypersensitivity Reaction Orai1Gt(XL922)Byg>/Orai1 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 18059270
Decreased Interferon-gamma Secretion Orai1Gt(XL922)Byg>/Orai1 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 18059270
Decreased Interleukin-2 Secretion Orai1Gt(XL922)Byg>/Orai1 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 18059270
Decreased Leukotriene Level Orai1Gt(XL922)Byg>/Orai1 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 18059270
Abnormal Mast Cell Physiology Orai1Gt(XL922)Byg>/Orai1<+ involves: 129P2/OlaHsd * C57BL/6 * DBA/2 18059270
Decreased Interferon-gamma Secretion Orai1Gt(XL922)Byg>/Orai1<+ involves: 129P2/OlaHsd * C57BL/6 * DBA/2 18059270
Decreased Leukotriene Level Orai1Gt(XL922)Byg>/Orai1<+ involves: 129P2/OlaHsd * C57BL/6 * DBA/2 18059270
Prenatal Lethality Orai1tm1Rao>/Orai1 C57BL/6-Orai1 18591248
Perinatal Lethality Orai1tm1Rao>/Orai1 C57BL/6-Orai1 18591248
Abnormal Cell Physiology Orai1tm1Rao>/Orai1 C57BL/6-Orai1 18591248
Abnormal T Cell Activation Orai1tm1Rao>/Orai1<+ C57BL/6-Orai1 18591248
Abnormal B Cell Activation Orai1tm1Rao>/Orai1<+ C57BL/6-Orai1 18591248
Perinatal Lethality Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Abnormal Cell-mediated Immunity Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Decreased Body Weight Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Short Vibrissae Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Alopecia Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Thin Skin Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Abnormal T Cell Activation Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Abnormal Mast Cell Physiology Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Blepharitis Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Abnormal Cytokine Secretion Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Abnormal Thymocyte Activation Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Abnormal B Cell Activation Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Decreased Interferon-gamma Secretion Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Decreased Interleukin-10 Secretion Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Decreased Interleukin-2 Secretion Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Decreased Interleukin-4 Secretion Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Decreased Survivor Rate Orai1tm1Rao>/Orai1 involves: C57BL/6 * ICR 18591248
Neonatal Lethality Orai1tm1Fesk>/Orai1 C57BL/6-Orai1 18952890
Decreased Platelet Calcium Level Orai1tm1Fesk>/Orai1 C57BL/6-Orai1 18952890
Abnormal Platelet Activation Orai1tm1Fesk>/Orai1 C57BL/6-Orai1 18952890