RAPID Lite

TYK2

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Primary Information

MGI:1929470
ENSMUSG00000032175

Gene Symbol

Tyk2

Affected Anatomical Systems

cellular phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,life span-post-weaning/aging,skeleton phenotype

Allele Details

Allele ID	Allele Symbol	Allele Type	Allele Name	PubMed Id
MGI:3706656	Tyk2^E775K	Spontaneous	E775K	11313413
MGI:2389582	Tyk2^tm1Shmd	Targeted (knock-out)	targeted mutation 1, Kazuya Shimoda	11070174

Phenotypic Details

Phenotypes	Allelic Composition	Genetic Background	PubMed Id
Abnormal T Cell Physiology	Tyk2^{tm1Shmd>/Tyk2}	involves: 129P2/OlaHsd	11070174
Abnormal T Cell Differentiation	Tyk2^{tm1Shmd>/Tyk2}	involves: 129P2/OlaHsd	11070174
Abnormal Cell Cycle	Tyk2^{tm1Shmd>/Tyk2}	involves: 129P2/OlaHsd	14617019
Abnormal Common Myeloid Progenitor Cell Morphology	Tyk2^{tm1Shmd>/Tyk2}	involves: 129P2/OlaHsd	14617019
Decreased Interferon-gamma Secretion	Tyk2^{tm1Shmd>/Tyk2}	involves: 129P2/OlaHsd	11070174
Abnormal Splenocyte Physiology	Tyk2^{tm1Shmd>/Tyk2}	involves: 129P2/OlaHsd	11070174
Decreased IgG Level	Tyk2^E775K>/Tyk2	B10.D1-H2/SgJ	11313413
Increased Susceptibility To Parasitic Infection	Tyk2^E775K>/Tyk2	B10.D1-H2/SgJ	11313414
Abnormal T-helper 1 Physiology	Tyk2^E775K>/Tyk2	B10.D1-H2/SgJ	11313413
Decreased Susceptibility To Induced Arthritis	Tyk2^E775K>/Tyk2	B10.D1-H2/SgJ	11313413
Decreased IgG1 Level	Tyk2^E775K>/Tyk2	B10.D1-H2/SgJ	11313413
Decreased IgG2a Level	Tyk2^E775K>/Tyk2	B10.D1-H2/SgJ	11313413
Decreased Interferon-gamma Secretion	Tyk2^E775K>/Tyk2	B10.D1-H2/SgJ	11313413,11313414
Increased Circulating Interleukin-12 Level	Tyk2^E775K>/Tyk2	B10.D1-H2/SgJ	11313414
Premature Death	Tyk2^{tm1Shmd>/Tyk2}	involves: 129P2/OlaHsd * C57BL/6	16148148
Increased Susceptibility To Viral Infection	Tyk2^{tm1Shmd>/Tyk2}	involves: 129P2/OlaHsd * C57BL/6	16148148
Abnormal Response To Infection	Tyk2^{tm1Shmd>/Tyk2}	involves: 129P2/OlaHsd * C57BL/6	16148148
Abnormal Nitric Oxide Homeostasis	Tyk2^{tm1Shmd>/Tyk2}	involves: 129P2/OlaHsd * C57BL/6	16148148