Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

WAS

External links	Primary Information
MGI:105059 ENSMUSG00000031165	Gene Symbol	Was
	Affected Anatomical Systems	cellular phenotype,digestive/alimentary phenotype,endocrine/exocrine gland phenotype,hematopoietic system phenotype,immune system phenotype,skeleton phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3028420 Wastm1Kas Targeted (knock-out) targeted mutation 1, Katherine A Siminovitch 10544204 MGI:1861707 Wastm1Sbs Targeted (knock-out) targeted mutation 1, Scott B Snapper 9697838
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Thymus Hypoplasia Wastm1Kas>/Was involves: 129/Sv * C57BL/6 10544204 Lymphoid Hypoplasia Wastm1Kas>/Was involves: 129/Sv * C57BL/6 10544204 Decreased Lymphocyte Cell Number Wastm1Kas>/Was involves: 129/Sv * C57BL/6 10544204 Decreased B Cell Number Wastm1Kas>/Was involves: 129/Sv * C57BL/6 10544204 Decreased T Cell Number Wastm1Kas>/Was involves: 129/Sv * C57BL/6 10544204 Decreased Double-positive T Cell Number Wastm1Kas>/Was involves: 129/Sv * C57BL/6 10544204 Decreased Platelet Cell Number Wastm1Kas>/Was involves: 129/Sv * C57BL/6 10544204 Abnormal Crypts Of Lieberkuhn Morphology Wastm1Sbs>/Was either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6) 9697838 Crypts Of Lieberkuhn Abscesses Wastm1Sbs>/Was either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6) 9697838 Increased Neutrophil Cell Number Wastm1Sbs>/Was either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6) 9697838 Decreased Lymphocyte Cell Number Wastm1Sbs>/Was either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6) 9697838 Decreased B Cell Number Wastm1Sbs>/Was either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6) 9697838 Decreased T Cell Number Wastm1Sbs>/Was either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6) 9697838 Decreased T Cell Proliferation Wastm1Sbs>/Was either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6) 9697838 Colitis Wastm1Sbs>/Was either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6) 9697838 Decreased Platelet Cell Number Wastm1Sbs>/Was either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6) 9697838 Abnormal B Cell Physiology Wastm1Sbs>/Was involves: C57BL/6 * CBA 11493455 Abnormal Mast Cell Morphology Wastm1Sbs>/Was involves: 129S/SvEv 14645152 Abnormal Bone Marrow Cell Morphology/development Wastm1Sbs>/Was involves: 129S/SvEv 12730112 Abnormal Osteoclast Physiology Wastm1Sbs>/Was involves: 129S/SvEv 14726392 Abnormal Mast Cell Physiology Wastm1Sbs>/Was involves: 129S/SvEv 14645152 Abnormal Cytokine Secretion Wastm1Sbs>/Was involves: 129S/SvEv 14645152 Abnormal Cell Migration Wastm1Sbs>/Was involves: 129S/SvEv 12730112 Abnormal Osteoclast Differentiation Wastm1Sbs>/Was involves: 129S/SvEv 14726392 Abnormal Dendritic Cell Antigen Presentation Wastm1Sbs>/Was involves: BALB/c 12807484 Decreased T Cell Proliferation Wastm1Sbs>/Was involves: BALB/c 12807484 Increased Leukocyte Cell Number Wastm1Sbs>/Was involves: 129S6/SvEvTac 19805221 Spleen Hyperplasia Wastm1Sbs>/Was involves: 129S6/SvEvTac 19805221 Increased Monocyte Cell Number Wastm1Sbs>/Was involves: 129S6/SvEvTac 19805221 Abnormal Double-negative T Cell Morphology Wastm1Sbs>/Was involves: 129S6/SvEvTac 17878299 Abnormal Dendritic Cell Physiology Wastm1Sbs>/Was involves: 129S6/SvEvTac 19805221 Abnormal Double-positive T Cell Morphology Wastm1Sbs>/Was involves: 129S6/SvEvTac 17878299 Abnormal Lymphocyte Morphology Wastm1Sbs>/Was involves: 129S6/SvEvTac 19805221 Decreased T Cell Number Wastm1Sbs>/Was involves: 129S6/SvEvTac 19805221 Increased B Cell Number Wastm1Sbs>/Was involves: 129S6/SvEvTac 19805221 Decreased T Cell Proliferation Wastm1Sbs>/Was involves: 129S6/SvEvTac 19805221 Abnormal Dendritic Cell Morphology Wastm1Sbs>/Was involves: 129S6/SvEvTac 19805221 Decreased Platelet Cell Number Wastm1Sbs>/Was involves: 129S6/SvEvTac 19805221 Abnormal Thymocyte Activation Wastm1Sbs>/Was involves: 129S6/SvEvTac 17878299 Increased Anti-double Stranded DNA Antibody Level Wastm1Sbs>/Was involves: 129S6/SvEvTac 19805221 Decreased NK Cell Number Wastm1Sbs>/Was involves: 129S6/SvEvTac 19805221 Increased Follicular B Cell Number Wastm1Sbs>/Was involves: 129S6/SvEvTac 19805221 Increased Splenocyte Number Wastm1Sbs>/Was involves: 129S6/SvEvTac 19805221 Increased Leukocyte Cell Number Wastm1Igl>/Was Not Specified 19805221 Spleen Hyperplasia Wastm1Igl>/Was Not Specified 19805221 Abnormal Dendritic Cell Physiology Wastm1Igl>/Was Not Specified 19805221 Abnormal Lymphocyte Morphology Wastm1Igl>/Was Not Specified 19805221 Decreased T Cell Number Wastm1Igl>/Was Not Specified 19805221 Increased B Cell Number Wastm1Igl>/Was Not Specified 19805221 Decreased T Cell Proliferation Wastm1Igl>/Was Not Specified 19805221 Abnormal Dendritic Cell Morphology Wastm1Igl>/Was Not Specified 19805221 Decreased Platelet Cell Number Wastm1Igl>/Was Not Specified 19805221 Increased Anti-double Stranded DNA Antibody Level Wastm1Igl>/Was Not Specified 19805221 Decreased NK Cell Number Wastm1Igl>/Was Not Specified 19805221 Increased Follicular B Cell Number Wastm1Igl>/Was Not Specified 19805221 Increased Splenocyte Number Wastm1Igl>/Was Not Specified 19805221 Increased Leukocyte Cell Number Wastm1Igl>/Y Not Specified 19805221 Spleen Hyperplasia Wastm1Igl>/Y Not Specified 19805221 Abnormal Dendritic Cell Physiology Wastm1Igl>/Y Not Specified 19805221 Abnormal Lymphocyte Morphology Wastm1Igl>/Y Not Specified 19805221 Decreased T Cell Number Wastm1Igl>/Y Not Specified 19805221 Increased B Cell Number Wastm1Igl>/Y Not Specified 19805221 Decreased T Cell Proliferation Wastm1Igl>/Y Not Specified 19805221 Abnormal Dendritic Cell Morphology Wastm1Igl>/Y Not Specified 19805221 Decreased Platelet Cell Number Wastm1Igl>/Y Not Specified 19805221 Increased Anti-double Stranded DNA Antibody Level Wastm1Igl>/Y Not Specified 19805221 Decreased NK Cell Number Wastm1Igl>/Y Not Specified 19805221 Increased Follicular B Cell Number Wastm1Igl>/Y Not Specified 19805221 Increased Splenocyte Number Wastm1Igl>/Y Not Specified 19805221 Increased Leukocyte Cell Number Wastm2Igl>/Y Not Specified 19805221 Abnormal Dendritic Cell Physiology Wastm2Igl>/Y Not Specified 19805221 Abnormal Lymphocyte Morphology Wastm2Igl>/Y Not Specified 19805221 Decreased T Cell Number Wastm2Igl>/Y Not Specified 19805221 Increased B Cell Number Wastm2Igl>/Y Not Specified 19805221 Decreased T Cell Proliferation Wastm2Igl>/Y Not Specified 19805221 Abnormal Dendritic Cell Morphology Wastm2Igl>/Y Not Specified 19805221 Decreased Platelet Cell Number Wastm2Igl>/Y Not Specified 19805221 Increased Anti-double Stranded DNA Antibody Level Wastm2Igl>/Y Not Specified 19805221 Decreased NK Cell Number Wastm2Igl>/Y Not Specified 19805221 Increased Follicular B Cell Number Wastm2Igl>/Y Not Specified 19805221 Increased Splenocyte Number Wastm2Igl>/Y Not Specified 19805221 Increased Leukocyte Cell Number Wastm2Igl>/Was Not Specified 19805221 Abnormal Dendritic Cell Physiology Wastm2Igl>/Was Not Specified 19805221 Abnormal Lymphocyte Morphology Wastm2Igl>/Was Not Specified 19805221 Decreased T Cell Number Wastm2Igl>/Was Not Specified 19805221 Increased B Cell Number Wastm2Igl>/Was Not Specified 19805221 Decreased T Cell Proliferation Wastm2Igl>/Was Not Specified 19805221 Abnormal Dendritic Cell Morphology Wastm2Igl>/Was Not Specified 19805221 Decreased Platelet Cell Number Wastm2Igl>/Was Not Specified 19805221 Increased Anti-double Stranded DNA Antibody Level Wastm2Igl>/Was Not Specified 19805221 Decreased NK Cell Number Wastm2Igl>/Was Not Specified 19805221 Increased Follicular B Cell Number Wastm2Igl>/Was Not Specified 19805221 Increased Splenocyte Number Wastm2Igl>/Was Not Specified 19805221 Increased Leukocyte Cell Number Wastm1Sbs>/Y involves: 129S6/SvEvTac 19805221 Spleen Hyperplasia Wastm1Sbs>/Y involves: 129S6/SvEvTac 19805221 Increased Monocyte Cell Number Wastm1Sbs>/Y involves: 129S6/SvEvTac 19805221 Abnormal Dendritic Cell Physiology Wastm1Sbs>/Y involves: 129S6/SvEvTac 19805221 Abnormal Lymphocyte Morphology Wastm1Sbs>/Y involves: 129S6/SvEvTac 19805221 Decreased T Cell Number Wastm1Sbs>/Y involves: 129S6/SvEvTac 19805221 Increased B Cell Number Wastm1Sbs>/Y involves: 129S6/SvEvTac 19805221 Decreased T Cell Proliferation Wastm1Sbs>/Y involves: 129S6/SvEvTac 19805221 Abnormal Dendritic Cell Morphology Wastm1Sbs>/Y involves: 129S6/SvEvTac 19805221 Decreased Platelet Cell Number Wastm1Sbs>/Y involves: 129S6/SvEvTac 19805221 Increased Anti-double Stranded DNA Antibody Level Wastm1Sbs>/Y involves: 129S6/SvEvTac 19805221 Decreased NK Cell Number Wastm1Sbs>/Y involves: 129S6/SvEvTac 19805221 Increased Follicular B Cell Number Wastm1Sbs>/Y involves: 129S6/SvEvTac 19805221 Increased Splenocyte Number Wastm1Sbs>/Y involves: 129S6/SvEvTac 19805221