Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

LCK

External links	Primary Information
MGI:96756 ENSMUSG00000000409	Gene Symbol	Lck
	Affected Anatomical Systems	embryogenesis phenotype,hematopoietic system phenotype,immune system phenotype,reproductive system phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3831661 Lckm1Btlr Chemically induced (ENU) mutation 1, Bruce Beutler MGI:4358985 Lcktm1.1Litt Targeted (knock-out) targeted mutation 1.1, Dan R Littman 19668367 MGI:3690319 Lcktm1Dbs Targeted (knock-in) targeted mutation 1, David B Straus 16923964 MGI:4358983 Lcktm1Litt Targeted (Floxed/Frt) targeted mutation 1, Dan R Littman 19668367 MGI:1857211 Lcktm1Mak Targeted (knock-out) targeted mutation 1, Tak Mak 1579166
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Thymus Hypoplasia Lcktm1Mak>/Lck involves: 129S2/SvPas 8934569,8934570 Decreased Thymocyte Number Lcktm1Mak>/Lck involves: 129S2/SvPas 1579166 Increased IgM Level Lcktm1Mak>/Lck involves: 129S2/SvPas 1579166 Abnormal Double-negative T Cell Morphology Lcktm1Mak>/Lck involves: 129S2/SvPas 10072519 Abnormal Lymphocyte Morphology Lcktm1Mak>/Lck involves: 129S2/SvPas 1579166 Decreased T Cell Number Lcktm1Mak>/Lck involves: 129S2/SvPas 1579166,8934569 Decreased Double-positive T Cell Number Lcktm1Mak>/Lck involves: 129S2/SvPas 10072519,1579166 Thymus Atrophy Lcktm1Mak>/Lck involves: 129S2/SvPas 1579166 Abnormal Thymocyte Activation Lcktm1Mak>/Lck involves: 129S2/SvPas 10072519 Abnormal T Cell Morphology Lcktm1Mak>/Lck involves: 129S2/SvPas 10072519 Decreased CD4-positive T Cell Number Lcktm1Mak>/Lck involves: 129S2/SvPas 8934570 Decreased CD8-positive T Cell Number Lcktm1Mak>/Lck involves: 129S2/SvPas 8934570 Abnormal Single-positive T Cell Number Lcktm1Mak>/Lck involves: 129S2/SvPas 8934569 Absent Single-positive T Cells Lcktm1Mak>/Lck involves: 129S2/SvPas 1579166 Decreased Gamma-delta T Cell Number Lcktm1Mak>/Lck involves: 129S2/SvPas 8934569 Decreased Gamma-delta Intraepithelial T Cell Number Lcktm1Mak>/Lck involves: 129S2/SvPas 8934570,9045930 Abnormal Alpha-beta Intraepithelial T Cell Morphology Lcktm1Mak>/Lck involves: 129S2/SvPas 9045930 Decreased IgG1 Level Lcktm1Mak>/Lck involves: 129S2/SvPas 1579166 Increased IgG2a Level Lcktm1Mak>/Lck involves: 129S2/SvPas 1579166 Increased IgG3 Level Lcktm1Mak>/Lck involves: 129S2/SvPas 1579166 Abnormal T Cell Differentiation Lcktm1Dbs>/Lck involves: C3H * C57BL/6 16923964 Decreased Thymocyte Number Lcktm1Dbs>/Lck involves: C3H * C57BL/6 16923964 Abnormal Double-negative T Cell Morphology Lcktm1Dbs>/Lck involves: C3H * C57BL/6 16923964 Abnormal CD4-positive T Cell Morphology Lcktm1Dbs>/Lck involves: C3H * C57BL/6 16923964 Abnormal CD8-positive T Cell Morphology Lcktm1Dbs>/Lck involves: C3H * C57BL/6 16923964 Decreased T Cell Number Lcktm1Dbs>/Lck involves: C3H * C57BL/6 16923964 Decreased T Cell Proliferation Lcktm1Dbs>/Lck involves: C3H * C57BL/6 16923964 Thymus Hypoplasia Lckm1Btlr>/Lck C57BL/6J-Lck Defective Cytotoxic T Cell Cytolysis Lckm1Btlr>/Lck C57BL/6J-Lck Thymus Atrophy Lckm1Btlr>/Lck C57BL/6J-Lck Decreased CD4-positive T Cell Number Lckm1Btlr>/Lck C57BL/6J-Lck Abnormal CD4-positive T Cell Differentiation Lckm1Btlr>/Lck C57BL/6J-Lck Decreased CD8-positive T Cell Number Lckm1Btlr>/Lck C57BL/6J-Lck Abnormal CD8-positive T Cell Differentiation Lckm1Btlr>/Lck C57BL/6J-Lck Abnormal Thymus Morphology Lcktm1.1Litt>/Lck Not Specified 19668367 Abnormal Immunoglobulin Level Lcktm1.1Litt>/Lck Not Specified 19668367 Abnormal Lymphocyte Morphology Lcktm1.1Litt>/Lck Not Specified 19668367