MYD88
Primary Info
Mutation
Mouse studies
DNA sequencing


External links Primary Information
MGI:108005
ENSMUSG00000032508		 Gene Symbol Myd88
Affected Anatomical Systems cellular phenotype,hearing/vestibular/ear phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id
MGI:3641234 Myd88lkd Chemically induced (ENU) lackadaisical 16832055
MGI:3641255 Myd88poc Chemically induced (ENU) pococurante 16832055
MGI:2385681 Myd88tm1Aki Targeted (knock-out) targeted mutation 1, Shizuo Akira 9697844
MGI:3809600 Myd88tm1Defr Targeted (Floxed/Frt) targeted mutation 1, Anthony L DeFranco 18656388
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id
Abnormal T Cell Physiology Myd88tm1Aki>/Myd88 Not Specified 12447442
Increased Susceptibility To Viral Infection Myd88tm1Aki>/Myd88 Not Specified 14993594
Abnormal Macrophage Physiology Myd88tm1Aki>/Myd88 Not Specified 12447442
Abnormal Dendritic Cell Physiology Myd88tm1Aki>/Myd88 Not Specified 12447442
Abnormal NK Cell Physiology Myd88tm1Aki>/Myd88 Not Specified 14993594
Decreased B Cell Proliferation Myd88tm1Aki>/Myd88 Not Specified 12447442
Abnormal Cytokine Secretion Myd88tm1Aki>/Myd88 Not Specified 14993594,15034168
Abnormal NK T Cell Physiology Myd88tm1Aki>/Myd88 Not Specified 14993594
Abnormal Immune System Physiology Myd88tm1Aki>/Myd88 B6.129P2-Myd88 17456769
Decreased Inflammatory Response Myd88tm1Aki>/Myd88 B6.129P2-Myd88 17357057
Abnormal T Cell Physiology Myd88tm1Aki>/Myd88 B6.129P2-Myd88 15800576
Increased Susceptibility To Viral Infection Myd88tm1Aki>/Myd88 B6.129P2-Myd88 15800576
Abnormal Macrophage Physiology Myd88tm1Aki>/Myd88 B6.129P2-Myd88 17159982
Abnormal Dendritic Cell Physiology Myd88tm1Aki>/Myd88 B6.129P2-Myd88 16461338,17159982
Abnormal Response To Infection Myd88tm1Aki>/Myd88 B6.129P2-Myd88 17456769
Decreased Susceptibility To Parasitic Infection Myd88tm1Aki>/Myd88 B6.129P2-Myd88 17135446
Abnormal NK Cell Physiology Myd88tm1Aki>/Myd88 B6.129P2-Myd88 18656388
Abnormal Cytokine Secretion Myd88tm1Aki>/Myd88 B6.129P2-Myd88 17159982
Increased Apoptosis Myd88tm1Aki>/Myd88 B6.129P2-Myd88 16244651
Abnormal Susceptibility To Hearing Loss Myd88tm1Aki>/Myd88 B6.129P2-Myd88 17357057
Abnormal Dendritic Cell Differentiation Myd88tm1Aki>/Myd88 B6.129P2-Myd88 18656388
Increased Dendritic Cell Number Myd88tm1Aki>/Myd88 B6.129P2-Myd88 17135446
Decreased Tumor Necrosis Factor Secretion Myd88tm1Aki>/Myd88 B6.129P2-Myd88 17135446,17159982,17456769
Decreased Interferon-alpha Secretion Myd88tm1Aki>/Myd88 B6.129P2-Myd88 15800576
Decreased Interferon-gamma Secretion Myd88tm1Aki>/Myd88 B6.129P2-Myd88 16461338,17135446
Decreased Interleukin-12 Secretion Myd88tm1Aki>/Myd88 B6.129P2-Myd88 17159982
Decreased Interleukin-12b Secretion Myd88tm1Aki>/Myd88 B6.129P2-Myd88 16461338,17135446
Decreased Interleukin-6 Secretion Myd88tm1Aki>/Myd88 B6.129P2-Myd88 16461338,17456769
Abnormal Chemokine Secretion Myd88tm1Aki>/Myd88 B6.129P2-Myd88 16244651
Increased Physiological Sensitivity To Xenobiotic Myd88tm1Aki>/Myd88 B6.129P2-Myd88 16244651
Abnormal Adaptive Immunity Myd88lkd>/Myd88 C57BL/6-Myd88 16832055
Abnormal Cell-mediated Immunity Myd88lkd>/Myd88 C57BL/6-Myd88 16832055
Abnormal Innate Immunity Myd88lkd>/Myd88 C57BL/6-Myd88 16832055
Abnormal Macrophage Physiology Myd88lkd>/Myd88 C57BL/6-Myd88 16832055
Abnormal Immune System Physiology Myd88poc>/Myd88 C57BL/6-Myd88 16832055
Increased Susceptibility To Bacterial Infection Myd88poc>/Myd88 C57BL/6-Myd88 16832055
Increased Susceptibility To Viral Infection Myd88poc>/Myd88 C57BL/6-Myd88 16832055
Abnormal Macrophage Physiology Myd88poc>/Myd88 C57BL/6-Myd88 16832055
Increased Susceptibility To Viral Infection Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd 16625202
Abnormal Neutrophil Physiology Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd 17158234
Increased IgE Level Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd 16703567
Abnormal Dendritic Cell Physiology Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd 16625202
Increased IgG1 Level Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd 16703567
Decreased Circulating Tumor Necrosis Factor Level Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd 18641654
Abnormal Interferon Level Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd 16625202
Abnormal Macrophage Physiology Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd * C57BL/6 17118979,18776906
Decreased IgG Level Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd * C57BL/6 18492657
Abnormal Dendritic Cell Physiology Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd * C57BL/6 17486093
Abnormal Cytokine Secretion Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd * C57BL/6 17118979
Decreased IgG2b Level Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd * C57BL/6 18492657
Decreased IgG3 Level Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd * C57BL/6 18492657
Decreased Interleukin-1 Beta Secretion Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd * C57BL/6 16407889
Decreased Interleukin-6 Secretion Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd * C57BL/6 17525287
Abnormal Chemokine Secretion Myd88tm1Aki>/Myd88 involves: 129P2/OlaHsd * C57BL/6 18776906