NOD2
Primary Info
Mutation
Mouse studies
DNA sequencing


External links Primary Information
MGI:2429397
ENSMUSG00000055994
Gene Symbol Nod2
Affected Anatomical Systems digestive/alimentary phenotype,growth/size phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,life span-post-weaning/aging
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id
MGI:3529594 Nod2tm1Flv Targeted (knock-out) targeted mutation 1, Richard A Flavell 15692051
MGI:3722087 Nod2tm1Jhgt Targeted (knock-out) targeted mutation 1, Jean-Pierre Hugot 17565376
MGI:3530578 Nod2tm1Mka Targeted (knock-out) targeted mutation 1, Michael Karin 15692052
MGI:2680581 Nod2tm1Pmu Targeted (knock-out) targeted mutation 1, Peter J Murray 14560001
MGI:3622092 Nod2tm1Vmd Targeted (knock-out) targeted mutation 1, Vishva M Dixit 16407890
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id
Abnormal Macrophage Physiology Nod2tm1Pmu>/Nod2 involves: BALB/c * C57BL/6 14560001
Decreased Susceptibility To Endotoxin Shock Nod2tm1Pmu>/Nod2 involves: BALB/c * C57BL/6 14560001
Altered Susceptibility To Infection Nod2tm1Flv>/Nod2 involves: 129S1/Sv * C57BL/6 15692051
Abnormal Macrophage Physiology Nod2tm1Flv>/Nod2 involves: 129S1/Sv * C57BL/6 15692051,18261938
Decreased IgG Level Nod2tm1Flv>/Nod2 involves: 129S1/Sv * C57BL/6 15692051
Decreased Tumor Necrosis Factor Secretion Nod2tm1Flv>/Nod2 involves: 129S1/Sv * C57BL/6 18261938
Decreased Interleukin-6 Secretion Nod2tm1Flv>/Nod2 involves: 129S1/Sv * C57BL/6 18261938
Decreased Susceptibility To Endotoxin Shock Nod2tm1Flv>/Nod2 involves: 129S1/Sv * C57BL/6 15692051
Weight Loss Nod2tm1Mka>/Nod2 involves: C57BL/6 15692052
Abnormal Macrophage Morphology Nod2tm1Mka>/Nod2 involves: C57BL/6 15692052
Increased Susceptibility To Induced Colitis Nod2tm1Mka>/Nod2 involves: C57BL/6 15692052
Increased Interleukin-1 Beta Secretion Nod2tm1Mka>/Nod2 involves: C57BL/6 15692052
Abnormal Cytokine Level Nod2tm1Mka>/Nod2 involves: C57BL/6 15692052
Increased Sensitivity To Xenobiotic Induced Morbidity/mortality Nod2tm1Mka>/Nod2 involves: C57BL/6 15692052
Abnormal Cytokine Secretion Nod2tm1Vmd>/Nod2 B6.129-Nod2 16407890
Abnormal Immune System Physiology Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376
Abnormal Immune System Morphology Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376
Abnormal Peyer's Patch Morphology Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376
Abnormal Lymph Node B Cell Domain Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376
Abnormal Response To Infection Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376
Increased Double-negative T Cell Number Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376
Increased CD4-positive T Cell Number Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376
Increased Peyer's Patch Number Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376
Enlarged Peyer's Patches Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376
Increased Susceptibility To Induced Colitis Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376
Abnormal Cytokine Level Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376
Abnormal Interferon Level Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376
Abnormal Interleukin Level Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376
Abnormal Tumor Necrosis Factor Level Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376
Abnormal Macrophage Physiology Nod2tm1Daph>/Nod2 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19898471
Abnormal Autophagy Nod2tm1Daph>/Nod2 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19898471