Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

NOD2

External links	Primary Information
MGI:2429397 ENSMUSG00000055994	Gene Symbol	Nod2
	Affected Anatomical Systems	digestive/alimentary phenotype,growth/size phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,life span-post-weaning/aging
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3529594 Nod2tm1Flv Targeted (knock-out) targeted mutation 1, Richard A Flavell 15692051 MGI:3722087 Nod2tm1Jhgt Targeted (knock-out) targeted mutation 1, Jean-Pierre Hugot 17565376 MGI:3530578 Nod2tm1Mka Targeted (knock-out) targeted mutation 1, Michael Karin 15692052 MGI:2680581 Nod2tm1Pmu Targeted (knock-out) targeted mutation 1, Peter J Murray 14560001 MGI:3622092 Nod2tm1Vmd Targeted (knock-out) targeted mutation 1, Vishva M Dixit 16407890
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Macrophage Physiology Nod2tm1Pmu>/Nod2 involves: BALB/c * C57BL/6 14560001 Decreased Susceptibility To Endotoxin Shock Nod2tm1Pmu>/Nod2 involves: BALB/c * C57BL/6 14560001 Altered Susceptibility To Infection Nod2tm1Flv>/Nod2 involves: 129S1/Sv * C57BL/6 15692051 Abnormal Macrophage Physiology Nod2tm1Flv>/Nod2 involves: 129S1/Sv * C57BL/6 15692051,18261938 Decreased IgG Level Nod2tm1Flv>/Nod2 involves: 129S1/Sv * C57BL/6 15692051 Decreased Tumor Necrosis Factor Secretion Nod2tm1Flv>/Nod2 involves: 129S1/Sv * C57BL/6 18261938 Decreased Interleukin-6 Secretion Nod2tm1Flv>/Nod2 involves: 129S1/Sv * C57BL/6 18261938 Decreased Susceptibility To Endotoxin Shock Nod2tm1Flv>/Nod2 involves: 129S1/Sv * C57BL/6 15692051 Weight Loss Nod2tm1Mka>/Nod2 involves: C57BL/6 15692052 Abnormal Macrophage Morphology Nod2tm1Mka>/Nod2 involves: C57BL/6 15692052 Increased Susceptibility To Induced Colitis Nod2tm1Mka>/Nod2 involves: C57BL/6 15692052 Increased Interleukin-1 Beta Secretion Nod2tm1Mka>/Nod2 involves: C57BL/6 15692052 Abnormal Cytokine Level Nod2tm1Mka>/Nod2 involves: C57BL/6 15692052 Increased Sensitivity To Xenobiotic Induced Morbidity/mortality Nod2tm1Mka>/Nod2 involves: C57BL/6 15692052 Abnormal Cytokine Secretion Nod2tm1Vmd>/Nod2 B6.129-Nod2 16407890 Abnormal Immune System Physiology Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376 Abnormal Immune System Morphology Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376 Abnormal Peyer's Patch Morphology Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376 Abnormal Lymph Node B Cell Domain Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376 Abnormal Response To Infection Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376 Increased Double-negative T Cell Number Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376 Increased CD4-positive T Cell Number Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376 Increased Peyer's Patch Number Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376 Enlarged Peyer's Patches Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376 Increased Susceptibility To Induced Colitis Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376 Abnormal Cytokine Level Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376 Abnormal Interferon Level Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376 Abnormal Interleukin Level Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376 Abnormal Tumor Necrosis Factor Level Nod2tm1Jhgt>/Nod2 B6.Cg-Nod2 17565376 Abnormal Macrophage Physiology Nod2tm1Daph>/Nod2 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19898471 Abnormal Autophagy Nod2tm1Daph>/Nod2 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19898471