Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

CD3E

External links	Primary Information
MGI:88332 ENSMUSG00000032093	Gene Symbol	Cd3e
	Affected Anatomical Systems	behavior/neurological phenotype,hematopoietic system phenotype,immune system phenotype,life span-post-weaning/aging,nervous system phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3776477 Cd3em1Btlr Chemically induced (ENU) mutation 1, Bruce Beutler MGI:2384123 Cd3etm1.1Lov Targeted (knock-out) targeted mutation 1.1, Paul E Love 9843989 MGI:2155671 Cd3etm1Cpt Targeted (knock-out) targeted mutation 1, Cox Terhorst 9885898 MGI:2384120 Cd3etm1Lov Targeted (knock-out) targeted mutation 1, Paul E Love 9843989 MGI:2155092 Cd3etm1Mal Targeted (knock-out) targeted mutation 1, Bernard Malissen 7588594
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Arrested T Cell Differentiation Cd3etm1Mal>/Cd3e involves: C57BL/6 12065839 Absent CD8-positive T Cells Cd3etm1Mal>/Cd3e involves: C57BL/6 12065839 Absent CD4-positive T Cells Cd3etm1Mal>/Cd3e involves: C57BL/6 12065839 Arrested T Cell Differentiation Cd3etm1Lov>/Cd3e involves: 129S1/Sv * 129X1/SvJ 9843989 Increased Double-negative T Cell Number Cd3etm1Lov>/Cd3e involves: 129S1/Sv * 129X1/SvJ 9843989 Decreased Double-positive T Cell Number Cd3etm1Lov>/Cd3e involves: 129S1/Sv * 129X1/SvJ 9843989 Abnormal T Cell Morphology Cd3etm1Lov>/Cd3e involves: 129S1/Sv * 129X1/SvJ 9843989 Arrested T Cell Differentiation Cd3etm1.1Lov>/Cd3e Not Specified 9843989 Increased Double-negative T Cell Number Cd3etm1.1Lov>/Cd3e Not Specified 9843989 Decreased Double-positive T Cell Number Cd3etm1.1Lov>/Cd3e Not Specified 9843989 Abnormal T Cell Morphology Cd3etm1.1Lov>/Cd3e Not Specified 9843989 Arrested T Cell Differentiation Cd3etm1Mal>/Cd3e C57BL/6-Cd3e 11751756 Abnormal Double-negative T Cell Morphology Cd3etm1Mal>/Cd3e C57BL/6-Cd3e 11751756 Abnormal B Cell Morphology Cd3etm1Mal>/Cd3e C57BL/6-Cd3e 11751756 Abnormal Regulatory T Cell Physiology Cd3etm1Mal>/Cd3e C57BL/6-Cd3e 12391195 Absent T Cells Cd3etm1Mal>/Cd3e C57BL/6-Cd3e 18209052 Increased Sensitivity To Induced Morbidity/mortality Cd3etm1Mal>/Cd3e C57BL/6-Cd3e 12391195 Seizures Cd3em1Btlr>/Cd3e C57BL/6J-Cd3e Abnormal Thymus Morphology Cd3em1Btlr>/Cd3e C57BL/6J-Cd3e Small Thymus Cd3em1Btlr>/Cd3e C57BL/6J-Cd3e Arrested T Cell Differentiation Cd3em1Btlr>/Cd3e C57BL/6J-Cd3e Absent T Cells Cd3em1Btlr>/Cd3e C57BL/6J-Cd3e Increased T Cell Apoptosis Cd3em1Btlr>/Cd3e C57BL/6J-Cd3e Thymus Hypoplasia Cd3etm1Cpt>/Cd3e involves: 129S4/SvJae * C57BL/6 9885898 Decreased Double-positive T Cell Number Cd3etm1Cpt>/Cd3e involves: 129S4/SvJae * C57BL/6 9885898 Absent T Cells Cd3etm1Cpt>/Cd3e involves: 129S4/SvJae * C57BL/6 9885898