CD40
Primary Info
Mutation
Mouse studies
DNA sequencing


External links Primary Information
MGI:88336
ENSMUSG00000017652		 Gene Symbol Cd40
Affected Anatomical Systems hematopoietic system phenotype,immune system phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id
MGI:3707600 Cd40tm1Arah Targeted (knock-out) targeted mutation 1, Amin Rahemtulla 11418692
MGI:2655321 Cd40tm1Geha Targeted (knock-out) targeted mutation 1, Raif S Geha 7527552
MGI:1857457 Cd40tm1Kik Targeted (knock-out) targeted mutation 1, Hitoshi Kikutani 7534202
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id
Increased Susceptibility To Bacterial Infection Cd40tm1Kik>/Cd40 B6.129P2-Cd40/J 14670300
Abnormal Dendritic Cell Physiology Cd40tm1Kik>/Cd40 B6.129P2-Cd40/J 14670300
Abnormal Humoral Immune Response Cd40tm1Kik>/Cd40 involves: 129P2/OlaHsd * C57BL/6 7534202
Decreased Immunoglobulin Level Cd40tm1Kik>/Cd40 involves: 129P2/OlaHsd * C57BL/6 7534202
Decreased Neutrophil Cell Number Cd40tm1Kik>/Cd40 involves: 129P2/OlaHsd * C57BL/6 7534202
Decreased IgA Level Cd40tm1Kik>/Cd40 involves: 129P2/OlaHsd * C57BL/6 7534202
Decreased IgE Level Cd40tm1Kik>/Cd40 involves: 129P2/OlaHsd * C57BL/6 7534202
Decreased Susceptibility To Type II Hypersensitivity Reaction Cd40tm1Kik>/Cd40 involves: 129P2/OlaHsd * C57BL/6 10760808
Absent Spleen Germinal Center Cd40tm1Kik>/Cd40 involves: 129P2/OlaHsd * C57BL/6 7534202
Decreased IgG1 Level Cd40tm1Kik>/Cd40 involves: 129P2/OlaHsd * C57BL/6 7534202
Decreased IgG2a Level Cd40tm1Kik>/Cd40 involves: 129P2/OlaHsd * C57BL/6 7534202
Decreased IgG2b Level Cd40tm1Kik>/Cd40 involves: 129P2/OlaHsd * C57BL/6 7534202
Decreased IgG3 Level Cd40tm1Kik>/Cd40 involves: 129P2/OlaHsd * C57BL/6 7534202
Abnormal Immunoglobulin Level Cd40tm1Arah>/Cd40 B6.129S1-Cd40 11418692
Decreased IgE Level Cd40tm1Arah>/Cd40 B6.129S1-Cd40 11418692
Decreased IgG Level Cd40tm1Arah>/Cd40 B6.129S1-Cd40 11418692
Decreased IgM Level Cd40tm1Arah>/Cd40 B6.129S1-Cd40 11418692
Increased IgM Level Cd40tm1Arah>/Cd40 B6.129S1-Cd40 11418692
Abnormal Response To Transplant Cd40tm1Arah>/Cd40 B6.129S1-Cd40 11418692
Absent Spleen Germinal Center Cd40tm1Arah>/Cd40 B6.129S1-Cd40 11418692
Decreased IgG1 Level Cd40tm1Arah>/Cd40 B6.129S1-Cd40 11418692
Decreased IgG2b Level Cd40tm1Arah>/Cd40 B6.129S1-Cd40 11418692
Increased IgG3 Level Cd40tm1Arah>/Cd40 B6.129S1-Cd40 11418692
Decreased IgA Level Cd40tm1Geha>/Cd40 involves: 129S4/SvJae * C57BL/6 9088978
Decreased Spleen Germinal Center Number Cd40tm1Geha>/Cd40 involves: 129S4/SvJae * C57BL/6 9088978
Decreased Spleen Germinal Center Size Cd40tm1Geha>/Cd40 involves: 129S4/SvJae * C57BL/6 9088978
Decreased IgG1 Level Cd40tm1Geha>/Cd40 involves: 129S4/SvJae * C57BL/6 9088978
Decreased IgG2a Level Cd40tm1Geha>/Cd40 involves: 129S4/SvJae * C57BL/6 9088978
Decreased IgG2b Level Cd40tm1Geha>/Cd40 involves: 129S4/SvJae * C57BL/6 9088978
Abnormal Lymph Node Germinal Center Cd40tm1Geha>/Cd40 involves: 129S4/SvJae * C57BL/6 9088978