Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

CD40LG

External links	Primary Information
MGI:88337 ENSMUSG00000031132	Gene Symbol	Cd40lg
	Affected Anatomical Systems	digestive/alimentary phenotype,endocrine/exocrine gland phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,nervous system phenotype,other phenotype,reproductive system phenotype,skeleton phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:2182733 Cd40lgtm1Flv Targeted (knock-out) targeted mutation 1, Richard A Flavell 7882172 MGI:1857145 Cd40lgtm1Imx Targeted (knock-out) targeted mutation 1, Immunex 7964465
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Immune System Physiology Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 7882172 Abnormal Immune System Morphology Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 7882172 Abnormal Adaptive Immunity Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 7882172 Abnormal T Cell Differentiation Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 7882172 Decreased Immunoglobulin Level Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 7882172 Decreased IgA Level Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 7882172 Decreased IgD Level Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 7882172 Decreased IgE Level Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 7882172 Decreased Double-positive T Cell Number Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 7882172 Abnormal T-helper 2 Physiology Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 7882172 Abnormal Class Switch Recombination Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 7882172 Increased CD4-positive T Cell Number Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 7882172 Abnormal Osteoclast Differentiation Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 17360404 Absent Spleen Germinal Center Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 7882172 Decreased IgG1 Level Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 7882172 Decreased IgG3 Level Cd40lgtm1Flv>/Cd40lg involves: 129S2/SvPas * C57BL/6 7882172 Abnormal Immune System Physiology Cd40lgtm1Imx>/Y involves: 129S2/SvPas * C57BL/6 7964465 Abnormal Antigen Presentation Cd40lgtm1Imx>/Y involves: 129S2/SvPas * C57BL/6 7964465 Abnormal Lymph Node Morphology Cd40lgtm1Imx>/Y involves: 129S2/SvPas * C57BL/6 7964465 Decreased Immunoglobulin Level Cd40lgtm1Imx>/Y involves: 129S2/SvPas * C57BL/6 7964465 Decreased IgA Level Cd40lgtm1Imx>/Y involves: 129S2/SvPas * C57BL/6 7964465 Decreased IgE Level Cd40lgtm1Imx>/Y involves: 129S2/SvPas * C57BL/6 7964465 Abnormal Immune System Organ Morphology Cd40lgtm1Imx>/Y involves: 129S2/SvPas * C57BL/6 7964465 Abnormal Class Switch Recombination Cd40lgtm1Imx>/Y involves: 129S2/SvPas * C57BL/6 7964465 Lymph Node Hypoplasia Cd40lgtm1Imx>/Y involves: 129S2/SvPas * C57BL/6 7964465 Absent Spleen Germinal Center Cd40lgtm1Imx>/Y involves: 129S2/SvPas * C57BL/6 7964465 Decreased IgG1 Level Cd40lgtm1Imx>/Y involves: 129S2/SvPas * C57BL/6 7964465 Decreased IgG2b Level Cd40lgtm1Imx>/Y involves: 129S2/SvPas * C57BL/6 7964465 Absent Lymph Node Germinal Center Cd40lgtm1Imx>/Y involves: 129S2/SvPas * C57BL/6 7964465 Decreased Susceptibility To Autoimmune Diabetes Cd40lgtm1Flv>/Cd40lg NOD.129S2-Cd40lg 15467837 Decreased Regulatory T Cell Number Cd40lgtm1Flv>/Cd40lg NOD.129S2-Cd40lg 15467837 Abnormal T Cell Clonal Deletion Cd40lgtm1Imx>/Cd40lg involves: 129S2/SvPas * C57BL/6J * BALB/c 11342622 Abnormal Thalamus Morphology Cd40lgtm1Imx>/Cd40lg B6.129S2-Cd40lg/J 15885854 Abnormal Blood Coagulation Cd40lgtm1Imx>/Cd40lg involves: 129S2/SvPas * C57BL/6 11875495 Neurodegeneration Cd40lgtm1Imx>/Cd40lg involves: 129S2/SvPas * C57BL/6 15071493 Spongiform Encephalopathy Cd40lgtm1Imx>/Cd40lg involves: 129S2/SvPas * C57BL/6 15071493 Increased Susceptibility To Prion Infection Cd40lgtm1Imx>/Cd40lg involves: 129S2/SvPas * C57BL/6 15071493 Loss Of Cortex Neurons Cd40lgtm1Imx>/Cd40lg involves: 129S2/SvPas * C57BL/6 15071493 Abnormal Nervous System Physiology Cd40lgtm1Imx>/Cd40lg involves: 129S2/SvPas * C57BL/6 15071493 Abnormal Microglial Cell Physiology Cd40lgtm1Imx>/Cd40lg involves: 129S2/SvPas * C57BL/6 15071493