Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

NLRP3

External links	Primary Information
MGI:2653833 ENSMUSG00000032691	Gene Symbol	Nlrp3
	Affected Anatomical Systems	homeostasis/metabolism phenotype,immune system phenotype,life span-post-weaning/aging
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3686871 Nlrp3tm1Flv Targeted (knock-out) targeted mutation 1, Richard A Flavell 16546100 MGI:3850011 Nlrp3tm1Hhf Targeted (knock-in) targeted mutation 1, Hal M Hoffman 19501000 MGI:3721141 Nlrp3tm1Tsc Targeted (Reporter) targeted mutation 1, Jurg Tschopp 16407889 MGI:3622094 Nlrp3tm1Vmd Targeted (knock-out) targeted mutation 1, Vishva M Dixit 16407890 MGI:3850069 Nlrp3tm1Wstr Targeted (Floxed/Frt) targeted mutation 1, Warren Strober 19501001 MGI:3850013 Nlrp3tm2Hhf Targeted (knock-in) targeted mutation 2, Hal M Hoffman 19501000
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Response To Infection Nlrp3tm1Vmd>/Nlrp3 involves: C57BL/6N 16407890 Abnormal Cytokine Secretion Nlrp3tm1Vmd>/Nlrp3 involves: C57BL/6N 16407890 Decreased Susceptibility To Endotoxin Shock Nlrp3tm1Vmd>/Nlrp3 involves: C57BL/6N 16407890 Abnormal Macrophage Physiology Nlrp3tm1Flv>/Nlrp3 involves: 129S5/SvEvBrd * C57BL/6 16546100 Decreased Susceptibility To Type IV Hypersensitivity Reaction Nlrp3tm1Flv>/Nlrp3 involves: 129S5/SvEvBrd * C57BL/6 16546100 Decreased Circulating Interleukin-18 Level Nlrp3tm1Flv>/Nlrp3 involves: 129S5/SvEvBrd * C57BL/6 16546100 Decreased Circulating Interleukin-1 Beta Level Nlrp3tm1Flv>/Nlrp3 involves: 129S5/SvEvBrd * C57BL/6 16546100 Decreased Susceptibility To Endotoxin Shock Nlrp3tm1Flv>/Nlrp3 involves: 129S5/SvEvBrd * C57BL/6 16546100 Decreased Interleukin-1 Beta Secretion Nlrp3tm1Tsc>/Nlrp3 C57BL/6-Nlrp3 16407889 Enlarged Liver Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Abnormal Lymph Node Morphology Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Chronic Inflammation Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Reduced Fertility Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Dermatitis Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Postnatal Growth Retardation Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Increased Leukocyte Cell Number Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Enlarged Lymph Nodes Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Enlarged Spleen Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Abnormal Spleen Red Pulp Morphology Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Abnormal Macrophage Physiology Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Increased Activated T Cell Number Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Abnormal Dendritic Cell Physiology Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Increased Susceptibility To Type IV Hypersensitivity Reaction Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Increased Anti-double Stranded DNA Antibody Level Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Abnormal CD4-positive T Cell Number Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Increased T-helper 1 Cell Number Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Postnatal Slow Weight Gain Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Increased Interleukin-1 Beta Secretion Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Increased Interleukin-17 Secretion Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Increased Interleukin-18 Secretion Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Decreased Survivor Rate Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001 Abnormal Bone Marrow Cell Physiology Nlrp3tm1Wstr>/Nlrp3<+ involves: C57BL/6 19501001