Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

CXCR4

External links	Primary Information
MGI:109563 ENSMUSG00000045382	Gene Symbol	Cxcr4
	Affected Anatomical Systems	cardiovascular system phenotype,digestive/alimentary phenotype,embryogenesis phenotype,growth/size phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,lethality-prenatal/perinatal,muscle phenotype,nervous system phenotype,renal/urinary system phenotype,reproductive system phenotype,respiratory system phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:1934166 Cxcr4tm1Qma Targeted (knock-out) targeted mutation 1, Qing Ma 9689100 MGI:1934442 Cxcr4tm1Tng Targeted (knock-out) targeted mutation 1, Takashi Nagasawa 9634237 MGI:1934407 Cxcr4tm1Yzo Targeted (knock-out) targeted mutation 1, Yong-Rui Zou 9634238 MGI:3628644 Cxcr4tm2Tng Targeted (Floxed/Frt) targeted mutation 2, Takashi Nagasawa 15189736 MGI:3525214 Cxcr4tm2Yzo Targeted (Floxed/Frt) targeted mutation 2, Yong-Rui Zou 15520246
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Decreased Body Size Cxcr4tm1Qma>/Cxcr4 involves: 129X1/SvJ 9689100 Perinatal Lethality Cxcr4tm1Qma>/Cxcr4 involves: 129X1/SvJ 9689100 Impaired Myelopoiesis Cxcr4tm1Qma>/Cxcr4 involves: 129X1/SvJ 9689100 Decreased Bone Marrow Cell Number Cxcr4tm1Qma>/Cxcr4 involves: 129X1/SvJ 9689100 Atelectasis Cxcr4tm1Qma>/Cxcr4 involves: 129X1/SvJ 9689100 Kidney Vascular Congestion Cxcr4tm1Qma>/Cxcr4 involves: 129X1/SvJ 9689100 Kidney Hemorrhage Cxcr4tm1Qma>/Cxcr4 involves: 129X1/SvJ 9689100 Ectopic Purkinje Cell Cxcr4tm1Qma>/Cxcr4 involves: 129X1/SvJ 9689100 Abnormal Cerebellum Morphology Cxcr4tm1Qma>/Cxcr4 involves: 129X1/SvJ 9689100 Absent Cerebellar Foliation Cxcr4tm1Qma>/Cxcr4 involves: 129X1/SvJ 9689100 Thin External Granule Cell Layer Cxcr4tm1Qma>/Cxcr4 involves: 129X1/SvJ 9689100 Decreased Pro-B Cell Number Cxcr4tm1Qma>/Cxcr4 involves: 129X1/SvJ 9689100 Abnormal Lymphopoiesis Cxcr4tm1Yzo>/Cxcr4 Not Specified 9634238 Impaired Myelopoiesis Cxcr4tm1Yzo>/Cxcr4 Not Specified 9634238 Hydrops Fetalis Cxcr4tm1Yzo>/Cxcr4 Not Specified 9634238 Abnormal Ventricular Septum Morphology Cxcr4tm1Yzo>/Cxcr4 Not Specified 9634238 Abnormal Cerebral Cortex Morphology Cxcr4tm1Yzo>/Cxcr4 Not Specified 11983855 Abnormal Cerebellum Morphology Cxcr4tm1Yzo>/Cxcr4 Not Specified 9634238 Abnormal Dentate Gyrus Morphology Cxcr4tm1Yzo>/Cxcr4 Not Specified 11983855,12183377 Abnormal Cerebellum External Granule Cell Layer Morphology Cxcr4tm1Yzo>/Cxcr4 Not Specified 9634238 Abnormal Leukopoiesis Cxcr4tm1Yzo>/Cxcr4 Not Specified 9634238 Abnormal Primordial Germ Cell Migration Cxcr4tm1Yzo>/Cxcr4 Not Specified 12900445 Lethality Throughout Fetal Growth And Development Cxcr4tm1Yzo>/Cxcr4 Not Specified 9634238 Decreased Fetal Size Cxcr4tm1Yzo>/Cxcr4 Not Specified 9634238 Decreased Primordial Germ Cell Number Cxcr4tm1Yzo>/Cxcr4 Not Specified 12900445 Perinatal Lethality Cxcr4tm1Tng>/Cxcr4 involves: 129P2/OlaHsd 9634237 Failure Of Myelopoiesis Cxcr4tm1Tng>/Cxcr4 involves: 129P2/OlaHsd 9634237 Gastrointestinal Hemorrhage Cxcr4tm1Tng>/Cxcr4 involves: 129P2/OlaHsd 9634237 Abnormal Angiogenesis Cxcr4tm1Tng>/Cxcr4 involves: 129P2/OlaHsd 9634237 Neonatal Lethality Cxcr4tm1Tng>/Cxcr4 involves: 129P2/OlaHsd 9634237 Abnormal B Cell Differentiation Cxcr4tm1Tng>/Cxcr4 involves: 129P2/OlaHsd 9634237 Abnormal Ventricular Septum Morphology Cxcr4tm1Tng>/Cxcr4 involves: 129P2/OlaHsd 9634237 Abnormal T Cell Differentiation Cxcr4tm1Tng>/Cxcr4 B6.Cg-Cxcr4 12707343 Decreased Double-positive T Cell Number Cxcr4tm1Tng>/Cxcr4 B6.Cg-Cxcr4 12707343 Abnormal Primordial Germ Cell Migration Cxcr4tm1Tng>/Cxcr4 B6.Cg-Cxcr4 12684531 Abnormal Myogenesis Cxcr4tm1Qma>/Cxcr4 B6.129X-Cxcr4/J 16166380 Abnormal Muscle Progenitor Cell Migration Cxcr4tm1Qma>/Cxcr4 B6.129X-Cxcr4/J 16166380