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ATM

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Primary Information

Gene Symbol

Atm

Affected Anatomical Systems

behavior/neurological phenotype,cellular phenotype,endocrine/exocrine gland phenotype,growth/size phenotype,hematopoietic system phenotype,immune system phenotype,lethality-prenatal/perinatal,life span-post-weaning/aging,nervous system phenotype,reproductive system phenotype,tumorigenesis

Allele Details

Allele ID	Allele Symbol	Allele Type	Allele Name	PubMed Id
MGI:1857132	Atm^tm1Awb	Targeted (knock-out)	targeted mutation 1, Anthony Wynshaw Boris	8689683
MGI:1926343	Atm^tm1Bal	Targeted (knock-out)	targeted mutation 1, David Baltimore	8843193
MGI:1933748	Atm^tm1Fwa	Targeted (knock-out)	targeted mutation 1, Frederick W Alt	10716718
MGI:1926875	Atm^tm1Led	Targeted (knock-out)	targeted mutation 1, Philip Leder	8917548
MGI:2181756	Atm^tm1Mfl	Targeted (knock-out)	targeted mutation 1, Martin F Lavin	11389091
MGI:1933746	Atm^tm1Pmc	Targeted (knock-out)	targeted mutation 1, Peter J McKinnon	9582124
MGI:3851145	Atm^tm2.1Fwa	Targeted (Floxed/Frt)	targeted mutation 2.1, Frederick W Alt	19450527

Phenotypic Details

Phenotypes	Allelic Composition	Genetic Background	PubMed Id
Abnormal Reproductive System Physiology	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Decreased Body Size	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Premature Death	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Abnormal Gametogenesis	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Increased Cellular Sensitivity To Gamma-irradiation	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Abnormal Female Reproductive System Morphology	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Abnormal Male Reproductive System Morphology	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Decreased Body Weight	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Increased Mortality Induced By Gamma-irradiation	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Hypoactivity	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Impaired Coordination	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Short Stride Length	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Small Ovary	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Abnormal Seminiferous Tubule Morphology	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Small Testis	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Abnormal Uterus Morphology	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Arrest Of Spermatogenesis	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Female Infertility	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Male Infertility	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
T Cell Derived Lymphoma	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Abnormal Purkinje Cell Morphology	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	10449794
Decreased Activated T Cell Number	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Decreased T Cell Number	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Abnormal Lysosome Morphology	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	10639172
Decreased Vertical Activity	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Decreased Double-positive T Cell Number	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Increased Double-positive T Cell Number	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Absent Ovarian Follicles	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Azoospermia	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Thymic Lymphoma	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Abnormal Cell Physiology	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Abnormal Cell Cycle	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Oxidative Stress	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	10449794
Absent Oocytes	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Absent Estrus	Atm^tm1Awb>/Atm	either: 129S6/SvEvTac-Atm or (involves: 129S6/SvEvTac * NIH Black Swiss)	8689683
Abnormal Cell Proliferation	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843193
Premature Death	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Abnormal Gametogenesis	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Increased Cellular Sensitivity To Gamma-irradiation	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843193
Abnormal Ovary Morphology	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Decreased Body Weight	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Postnatal Growth Retardation	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Abnormal T Cell Physiology	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Female Infertility	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Male Infertility	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Small Thymus	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Decreased Thymocyte Number	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Decreased IgG Level	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Purkinje Cell Degeneration	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	9356511
Abnormal Cerebellar Molecular Layer	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	9356511
Absent Ovarian Follicles	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Abnormal Female Meiosis	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Thymic Lymphoma	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Abnormal Cell Cycle	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843193
Neuron Degeneration	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	9356511
Abnormal Microglial Cell Physiology	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	9356511
Abnormal Cerebellar Granule Cell Morphology	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	9356511
Absent Oocytes	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Decreased Pre-B Cell Number	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Arrest Of Male Meiosis	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Decreased IgG2a Level	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Decreased IgG2b Level	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Decreased IgG3 Level	Atm^tm1Bal>/Atm	involves: 129S4/SvJae	8843194
Premature Death	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Increased Cellular Sensitivity To Gamma-irradiation	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Decreased Body Weight	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Hypoactivity	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Postnatal Growth Retardation	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Female Infertility	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Male Infertility	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Decreased Thymocyte Number	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Abnormal Purkinje Cell Morphology	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Ectopic Purkinje Cell	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Thin Cerebellar Molecular Layer	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Decreased Lymphocyte Cell Number	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Decreased T Cell Number	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Thymic Lymphoma	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Abnormal Motor Learning	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Decreased Pre-B Cell Number	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Decreased Immature B Cell Number	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Abnormal Purkinje Cell Dendrite Morphology	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Decreased Splenocyte Number	Atm^tm1Fwa>/Atm	involves: 129S4/SvJae * C57BL/6	10716718
Decreased Body Size	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	8917548
Premature Death	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	11389091
Abnormal Testis Morphology	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	8917548
Decreased Body Weight	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	8917548
Small Testis	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	8917548
Abnormal T Cell Differentiation	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	8917548
Male Infertility	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	8917548
Small Thymus	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	8917548
Abnormal Purkinje Cell Morphology	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	14673010
Decreased Thymus Cortex Area	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	8917548
Increased Double-positive T Cell Number	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	8917548
Azoospermia	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	8917548
Thymic Lymphoma	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	11389091,8917548
Abnormal Chromosome Morphology	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	11389091
Chromosome Breakage	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	8917548
Increased Cellular Sensitivity To Ionizing Radiation	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	11389091
Decreased CD4-positive T Cell Number	Atm^tm1Led>/Atm	involves: 129S6/SvEvTac * Black Swiss	8917548
Infertility	Atm^tm1Pmc>/Atm	involves: 129X1/SvJ * C57BL/6	9582124
Lymphoma	Atm^tm1Pmc>/Atm	involves: 129X1/SvJ * C57BL/6	9582124
Decreased Cellular Sensitivity To Ionizing Radiation	Atm^tm1Pmc>/Atm	involves: 129X1/SvJ * C57BL/6	9582124
Decreased Body Size	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Premature Death	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Abnormal Gametogenesis	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Abnormal Immune System Cell Morphology	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Abnormal Oogenesis	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Abnormal Spermatogenesis	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Increased Tumor Incidence	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Postnatal Growth Retardation	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Abnormal T Cell Differentiation	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Seminiferous Tubule Degeneration	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Small Lymph Nodes	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Enlarged Spleen	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Small Spleen	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Small Thymus	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Decreased Thymocyte Number	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Abnormal Purkinje Cell Morphology	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	14673010
Abnormal Immune System Organ Morphology	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Increased Double-negative T Cell Number	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Thymic Lymphoma	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Abnormal Chromosome Morphology	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Abnormal Testis Development	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Increased Cellular Sensitivity To Ionizing Radiation	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Abnormal Spermatocyte Morphology	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Abnormal Spermatid Morphology	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Increased Single-positive T Cell Number	Atm^tm1Mfl>/Atm	involves: 129T2/SvEms * C57BL/6J	11389091
Decreased Cellular Sensitivity To Gamma-irradiation	Atm^tm1Pmc>/Atm	Not Specified	12192050
Abnormal Cell Cycle Checkpoint Function	Atm^tm1Pmc>/Atm	Not Specified	12192050
Premature Death	Atm^tm1Awb>/Atm	involves: 129S6/SvEvTac * C57BL/6	16357220
Thymic Lymphoma	Atm^tm1Awb>/Atm	involves: 129S6/SvEvTac * C57BL/6	16357220
Chromosome Breakage	Atm^tm1Awb>/Atm	involves: 129S6/SvEvTac * C57BL/6	16357220
Abnormal Cell Cycle Checkpoint Function	Atm^tm1Awb>/Atm	involves: 129S6/SvEvTac * C57BL/6	16357220
Increased Tumor Incidence	Atm^{tm1Mfl>/Atm<+}	involves: 129T2/SvEms * C57BL/6J	12195425
Leukemia	Atm^{tm1Mfl>/Atm<+}	involves: 129T2/SvEms * C57BL/6J	12195425
Lymphoma	Atm^{tm1Mfl>/Atm<+}	involves: 129T2/SvEms * C57BL/6J	12195425
Sarcoma	Atm^{tm1Mfl>/Atm<+}	involves: 129T2/SvEms * C57BL/6J	12195425
Adenoma	Atm^{tm1Mfl>/Atm<+}	involves: 129T2/SvEms * C57BL/6J	12195425
Ovary Tumor	Atm^{tm1Mfl>/Atm<+}	involves: 129T2/SvEms * C57BL/6J	12195425
Premature Death	Atm^tm1Awb>/Atm	involves: 129S6/SvEvTac	15122331
Decreased Body Weight	Atm^tm1Awb>/Atm	involves: 129S6/SvEvTac	15122331
Increased Mortality Induced By Gamma-irradiation	Atm^tm1Awb>/Atm	involves: 129S6/SvEvTac	15122331
T Cell Derived Lymphoma	Atm^tm1Awb>/Atm	involves: 129S6/SvEvTac	15122331
Spontaneous Chromosome Breakage	Atm^tm1Awb>/Atm	involves: 129S6/SvEvTac	19450527
Abnormal Cell Cycle Checkpoint Function	Atm^tm1Awb>/Atm	involves: 129S6/SvEvTac	10677503
Abnormal Class Switch Recombination	Atm^tm1Awb>/Atm	involves: 129S6/SvEvTac	19450527
Decreased CD4-positive T Cell Number	Atm^tm1Awb>/Atm	involves: 129S6/SvEvTac	15122331
Decreased CD8-positive T Cell Number	Atm^tm1Awb>/Atm	involves: 129S6/SvEvTac	15122331