Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

DCLRE1C

External links	Primary Information
MGI:2441769 ENSMUSG00000026648	Gene Symbol	Dclre1c
	Affected Anatomical Systems	cellular phenotype,hematopoietic system phenotype,immune system phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:2667616 Dclre1ctm1.1Fwa Targeted (knock-out) targeted mutation 1.1, Frederick W Alt 12504013 MGI:3802969 Dclre1ctm1.1Jpdv Targeted (knock-out) targeted mutation 1.1, Jean-Pierre de Villartay 18501428 MGI:2667614 Dclre1ctm1Fwa Targeted (knock-out) targeted mutation 1, Frederick W Alt 12504013 MGI:3843046 Dclre1ctm1Jsek Targeted (knock-in) targeted mutation 1, JoAnn Sekiguchi 19349461 MGI:3574021 Dclre1ctm2Mcow Targeted (knock-out) targeted mutation 2, Morton J Cowan 15699179
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Decreased Thymocyte Number Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac * C57BL/6 12504013 Arrested B Cell Differentiation Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac * C57BL/6 12504013 Arrested T Cell Differentiation Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac * C57BL/6 12504013 Increased Cellular Sensitivity To Ionizing Radiation Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac * C57BL/6 12504013 Absent Immature B Cells Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac * C57BL/6 12504013 Chromosomal Instability Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac * C57BL/6 12504013 Arrested B Cell Differentiation Dclre1ctm1.1Fwa>/Dclre1c involves: 129S6/SvEvTac * C57BL/6 12504013 Arrested T Cell Differentiation Dclre1ctm1.1Fwa>/Dclre1c involves: 129S6/SvEvTac * C57BL/6 12504013 Abnormal Lymph Node Morphology Dclre1ctm2Mcow>/Dclre1c involves: 129/Sv * C57BL/6 15699179 Abnormal Leukocyte Physiology Dclre1ctm2Mcow>/Dclre1c involves: 129/Sv * C57BL/6 15699179 Small Lymph Nodes Dclre1ctm2Mcow>/Dclre1c involves: 129/Sv * C57BL/6 15699179 Small Spleen Dclre1ctm2Mcow>/Dclre1c involves: 129/Sv * C57BL/6 15699179 Abnormal Thymus Cortex Morphology Dclre1ctm2Mcow>/Dclre1c involves: 129/Sv * C57BL/6 15699179 Decreased Thymocyte Number Dclre1ctm2Mcow>/Dclre1c involves: 129/Sv * C57BL/6 15699179 Arrested B Cell Differentiation Dclre1ctm2Mcow>/Dclre1c involves: 129/Sv * C57BL/6 15699179 Arrested T Cell Differentiation Dclre1ctm2Mcow>/Dclre1c involves: 129/Sv * C57BL/6 15699179 Decreased Lymphocyte Cell Number Dclre1ctm2Mcow>/Dclre1c involves: 129/Sv * C57BL/6 15699179 Decreased B Cell Proliferation Dclre1ctm2Mcow>/Dclre1c involves: 129/Sv * C57BL/6 15699179 Decreased T Cell Proliferation Dclre1ctm2Mcow>/Dclre1c involves: 129/Sv * C57BL/6 15699179 Abnormal Cell Physiology Dclre1ctm2Mcow>/Dclre1c involves: 129/Sv * C57BL/6 15699179 Increased Cellular Sensitivity To Ionizing Radiation Dclre1ctm2Mcow>/Dclre1c involves: 129/Sv * C57BL/6 15699179 Decreased Thymus Weight Dclre1ctm2Mcow>/Dclre1c involves: 129/Sv * C57BL/6 15699179 Abnormal Spleen B Cell Follicle Morphology Dclre1ctm2Mcow>/Dclre1c involves: 129/Sv * C57BL/6 15699179 Abnormal B Cell Differentiation Dclre1ctm1.1Jpdv>/Dclre1c involves: 129P1/ReJ 18560421 Arrested T Cell Differentiation Dclre1ctm1.1Jpdv>/Dclre1c involves: 129P1/ReJ 18501428 Increased Cellular Sensitivity To Gamma-irradiation Dclre1ctm1Jsek>/Dclre1c involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19349461 Spleen Hypoplasia Dclre1ctm1Jsek>/Dclre1c involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19349461 Decreased Thymocyte Number Dclre1ctm1Jsek>/Dclre1c involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19349461 Decreased B Cell Number Dclre1ctm1Jsek>/Dclre1c involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19349461 Decreased Double-positive T Cell Number Dclre1ctm1Jsek>/Dclre1c involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19349461 Induced Chromosome Breakage Dclre1ctm1Jsek>/Dclre1c involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19349461 Decreased CD4-positive T Cell Number Dclre1ctm1Jsek>/Dclre1c involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19349461 Decreased CD8-positive T Cell Number Dclre1ctm1Jsek>/Dclre1c involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19349461 Increased Pro-B Cell Number Dclre1ctm1Jsek>/Dclre1c involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19349461 Decreased Pre-B Cell Number Dclre1ctm1Jsek>/Dclre1c involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19349461 Abnormal T Cell Receptor Beta Chain V(D)J Recombination Dclre1ctm1Jsek>/Dclre1c involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19349461 Abnormal Immunoglobulin Heavy Chain V(D)J Recombination Dclre1ctm1Jsek>/Dclre1c involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19349461 Increased Cellular Sensitivity To Gamma-irradiation Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac 19349461 Spleen Hypoplasia Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac 19349461 Decreased Thymocyte Number Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac 19349461 Arrested B Cell Differentiation Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac 19349461 Decreased Double-positive T Cell Number Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac 19349461 Induced Chromosome Breakage Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac 19349461 Absent B Cells Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac 19349461 Decreased CD4-positive T Cell Number Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac 19349461 Decreased CD8-positive T Cell Number Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac 19349461 Abnormal T Cell Receptor Beta Chain V(D)J Recombination Dclre1ctm1Fwa>/Dclre1c involves: 129S6/SvEvTac 19349461 Decreased Thymocyte Number Dclre1ctm2.2Jpdv>/Dclre1c B6.129S2-Dclre1c 19692705 Arrested B Cell Differentiation Dclre1ctm2.2Jpdv>/Dclre1c B6.129S2-Dclre1c 19692705 Arrested T Cell Differentiation Dclre1ctm2.2Jpdv>/Dclre1c B6.129S2-Dclre1c 19692705 Decreased Double-positive T Cell Number Dclre1ctm2.2Jpdv>/Dclre1c B6.129S2-Dclre1c 19692705 Decreased CD4-positive T Cell Number Dclre1ctm2.2Jpdv>/Dclre1c B6.129S2-Dclre1c 19692705 Decreased CD8-positive T Cell Number Dclre1ctm2.2Jpdv>/Dclre1c B6.129S2-Dclre1c 19692705 Decreased Mature B Cell Number Dclre1ctm2.2Jpdv>/Dclre1c B6.129S2-Dclre1c 19692705 Absent Immature B Cells Dclre1ctm2.2Jpdv>/Dclre1c B6.129S2-Dclre1c 19692705 Abnormal Mononuclear Leukocyte Morphology Dclre1ctm2.2Jpdv>/Dclre1c B6.129S2-Dclre1c 19692705 Decreased Splenocyte Number Dclre1ctm2.2Jpdv>/Dclre1c B6.129S2-Dclre1c 19692705