ELANE
Primary Info
Mutation
Mouse studies
DNA sequencing


External links Primary Information
MGI:2679229
ENSMUSG00000020125		 Gene Symbol Ela2
Affected Anatomical Systems hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,life span-post-weaning/aging,normal phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id
MGI:3803340 Elane/Prtn3tm1Deje Targeted (knock-out) targeted mutation 1, Dieter E Jenne 18568075
MGI:2182177 Elanetm1(cre)Roes Targeted (knock-in) targeted mutation 1, Jurgen Roes 10714686
MGI:3785264 Elanetm1Link Targeted (knock-in) targeted mutation 1, David C Link 12384420
MGI:2182771 Elanetm1Sds Targeted (knock-out) targeted mutation 1, Steven D Shapiro 9585238
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id
Increased Susceptibility To Infection Induced Morbidity/mortality Elanetm1(cre)Roes>/Elane involves: 129/Sv 10714686
Decreased Susceptibility To Bacterial Infection Induced Morbidity/mortality Elanetm1(cre)Roes>/Elane involves: 129/Sv 10714686
Increased Susceptibility To Bacterial Infection Elanetm1Sds>/Elane 129X1/SvJ-Elane 9585238
Abnormal Neutrophil Physiology Elanetm1Sds>/Elane 129X1/SvJ-Elane 9585238
Increased Susceptibility To Bacterial Infection Induced Morbidity/mortality Elanetm1Sds>/Elane 129X1/SvJ-Elane 9585238
Decreased Susceptibility To Bacterial Infection Induced Morbidity/mortality Elanetm1Sds>/Elane 129X1/SvJ-Elane 9585238
Decreased Physiological Sensitivity To Xenobiotic Elanetm1Sds>/Elane involves: 129X1/SvJ 16754715
No Abnormal Phenotype Detected Elanetm1Link>/Elane involves: 129X1/SvJ * C57BL/6 12384420
Abnormal Inflammatory Response Elanetm1Sds>/Elane involves: 129X1/SvJ * C57BL/6 16872848
Decreased Physiological Sensitivity To Xenobiotic Elanetm1Sds>/Elane B6.129X1-Elane 14633606
Abnormal Neutrophil Physiology Elane/Prtn3tm1Deje>/Elane/Prtn3 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 18568075
Impaired Neutrophil Recruitment Elane/Prtn3tm1Deje>/Elane/Prtn3 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 18568075
Impaired Neutrophil Recruitment Elanetm1(cre)Roes>/Elane involves: 129S6/SvEvTac 18568075