GFI1
Primary Info
Mutation
Mouse studies
DNA sequencing


External links Primary Information
MGI:103170
ENSMUSG00000029275		 Gene Symbol Gfi1
Affected Anatomical Systems behavior/neurological phenotype,growth/size phenotype,hearing/vestibular/ear phenotype,hematopoietic system phenotype,immune system phenotype,life span-post-weaning/aging,nervous system phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id
MGI:3696050 Gfi1tm1.1Wep Targeted (knock-out) targeted mutation 1.1, William E Paul 17116877
MGI:2449921 Gfi1tm1Sho Targeted (knock-out) targeted mutation 1, Stuart Orkin 12530980
MGI:2660761 Gfi1tm1Tmo Targeted (knock-out) targeted mutation 1, Tarik Moroy 11810106
MGI:3696049 Gfi1tm1Wep Targeted (Floxed/Frt) targeted mutation 1, William E Paul 17116877
MGI:3057195 Gfi1tm2Tmo Targeted (Reporter) targeted mutation 2, Tarik Moroy 15252036
MGI:3695403 Gfi1tm3(Gfib1)Tmo Targeted (knock-in) targeted mutation 3, Tarik Moroy 16397623
MGI:3695404 Gfi1tm4Tmo Targeted (knock-in) targeted mutation 4, Tarik Moroy 16397623
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id
Premature Death Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 11810106
Decreased Body Weight Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 11810106
Decreased Granulocyte Number Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 11810106
Abnormal T Cell Differentiation Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 11810106
Decreased Neutrophil Cell Number Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 11810106
Decreased Thymocyte Number Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 11810106
Deafness Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 15254021
Abnormal Cytokine Secretion Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 11810106
Abnormal Cochlear Inner Hair Cell Morphology Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 15254021
Abnormal Cochlear Outer Hair Cell Morphology Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 15254021
Cochlear Outer Hair Cell Degeneration Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 15254021
Abnormal Outer Hair Cell Stereociliary Bundle Morphology Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 15254021
Abnormal Inner Hair Cell Stereociliary Bundle Morphology Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 15254021
Short Inner Hair Cell Stereocilia Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 15254021
Abnormal Vestibular System Physiology Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 15254021
Abnormal Granulocyte Differentiation Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 11810106
Abnormal Monocyte Differentiation Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 11810106
Increased Tumor Necrosis Factor Secretion Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 11810106
Increased Interleukin-1 Beta Secretion Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 11810106
Decreased Interleukin-10 Secretion Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 11810106
Increased Susceptibility To Endotoxin Shock Gfi1tm1Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 11810106
Abnormal T Cell Differentiation Gfi1tm2Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 15252036
Decreased Neutrophil Cell Number Gfi1tm2Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 15252036
Decreased Thymocyte Number Gfi1tm2Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 15252036
Decreased Body Size Gfi1tm1Wep>/Gfi1 B6.129-Gfi1 17116877
Abnormal Hematopoiesis Gfi1tm1Wep>/Gfi1 B6.129-Gfi1 17116877
Abnormal T Cell Proliferation Gfi1tm1Wep>/Gfi1 B6.129-Gfi1 17116877
Decreased Body Size Gfi1tm1.1Wep>/Gfi1 B6.129-Gfi1 17116877
Thymus Hypoplasia Gfi1tm1.1Wep>/Gfi1 B6.129-Gfi1 17116877
Small Thymus Gfi1tm1.1Wep>/Gfi1 B6.129-Gfi1 17116877
Arrested T Cell Differentiation Gfi1tm1.1Wep>/Gfi1 B6.129-Gfi1 17116877
Decreased B Cell Number Gfi1tm1.1Wep>/Gfi1 B6.129-Gfi1 17116877
Decreased Body Size Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Premature Death Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Ataxia Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Hyperactivity Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Postnatal Growth Retardation Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Circling Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Organ Of Corti Degeneration Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Deafness Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Abnormal Cochlear Hair Cell Morphology Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Abnormal Vestibular Hair Cell Morphology Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Head Tilt Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Cochlear Ganglion Degeneration Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Increased Vestibular Hair Cell Number Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Cochlear Hair Cell Degeneration Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Cochlear Inner Hair Cell Degeneration Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Decreased Cochlear Outer Hair Cell Number Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Cochlear Outer Hair Cell Degeneration Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Degeneration Of Organ Of Corti Supporting Cells Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Abnormal Outer Hair Cell Stereociliary Bundle Morphology Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Abnormal Cochlear Hair Cell Development Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Abnormal Cochlear OHC Efferent Innervation Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Absent Startle Reflex Gfi1tm1Sho>/Gfi1 involves: 129S1/Sv * C57BL/6J 12441305
Abnormal Lymphopoiesis Gfi1tm4Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Abnormal T Cell Differentiation Gfi1tm4Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Decreased Neutrophil Cell Number Gfi1tm4Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Decreased Thymocyte Number Gfi1tm4Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Deafness Gfi1tm4Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Abnormal Monocyte Morphology Gfi1tm4Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Decreased Lymphocyte Cell Number Gfi1tm4Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Abnormal Neutrophil Morphology Gfi1tm4Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Decreased Double-negative T Cell Number Gfi1tm4Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Abnormal Cochlear Inner Hair Cell Morphology Gfi1tm4Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Abnormal Cochlear Outer Hair Cell Morphology Gfi1tm4Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Cochlear Outer Hair Cell Degeneration Gfi1tm4Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Absent Outer Hair Cell Stereocilia Gfi1tm4Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Abnormal Vestibular System Physiology Gfi1tm4Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Absent Pinna Reflex Gfi1tm4Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Decreased Granulocyte Number Gfi1tm3(Gfib1)Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Head Bobbing Gfi1tm3(Gfib1)Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Deafness Gfi1tm3(Gfib1)Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Abnormal Monocyte Morphology Gfi1tm3(Gfib1)Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Abnormal Vestibular Response Gfi1tm3(Gfib1)Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Abnormal Cochlear Inner Hair Cell Morphology Gfi1tm3(Gfib1)Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Abnormal Cochlear Outer Hair Cell Morphology Gfi1tm3(Gfib1)Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Cochlear Outer Hair Cell Degeneration Gfi1tm3(Gfib1)Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Absent Outer Hair Cell Stereocilia Gfi1tm3(Gfib1)Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Decreased Brainstem Auditory Evoked Potential Gfi1tm3(Gfib1)Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623
Absent Pinna Reflex Gfi1tm3(Gfib1)Tmo>/Gfi1 involves: 129S1/Sv * 129X1/SvJ 16397623