Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

IFNGR1

External links	Primary Information
MGI:107655 ENSMUSG00000020009	Gene Symbol	Ifngr1
	Affected Anatomical Systems	immune system phenotype,liver/biliary system phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:4361521 Ifngr1tm1.1Rost Targeted (knock-in) targeted mutation 1.1, Robyn Starr 19734231 MGI:1857286 Ifngr1tm1Agt Targeted (knock-out) targeted mutation 1, Michel Aguet 8456301
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Immunoglobulin Level Ifngr1tm1Agt>/Ifngr1 involves: 129S7/SvEvBrd 16123129 Increased Susceptibility To Viral Infection Ifngr1tm1Agt>/Ifngr1 involves: 129S7/SvEvBrd 11390995,16123129 Altered Tumor Susceptibility Ifngr1tm1Agt>/Ifngr1 involves: 129S7/SvEvBrd * C57BL/6 18354038 Increased Susceptibility To Experimental Autoimmune Uveoretinitis Ifngr1tm1Agt>/Ifngr1 involves: 129S7/SvEvBrd * C57BL/6 15902435 Increased Interferon-gamma Secretion Ifngr1tm1Agt>/Ifngr1 involves: 129S7/SvEvBrd * C57BL/6 15902435 Increased Interleukin-6 Secretion Ifngr1tm1Agt>/Ifngr1 involves: 129S7/SvEvBrd * C57BL/6 15902435 Increased Splenocyte Proliferation Ifngr1tm1Agt>/Ifngr1 involves: 129S7/SvEvBrd * C57BL/6 15902435 Decreased Metastatic Potential Ifngr1tm1.1Rost>/Ifngr1 involves: BALB/cJ * C57BL/6 19734231 Decreased Circulating Interferon-gamma Level Ifngr1tm1.1Rost>/Ifngr1 involves: BALB/cJ * C57BL/6 19734231 Decreased Circulating Interleukin-12 Level Ifngr1tm1.1Rost>/Ifngr1 involves: BALB/cJ * C57BL/6 19734231 Abnormal Chemokine Level Ifngr1tm1.1Rost>/Ifngr1 involves: BALB/cJ * C57BL/6 19734231 Increased Metastatic Potential Ifngr1tm1Agt>/Ifngr1 B6.129S7-Ifngr1/J 19734231 Decreased Circulating Interleukin-12 Level Ifngr1tm1Agt>/Ifngr1 B6.129S7-Ifngr1/J 19734231 Abnormal Chemokine Level Ifngr1tm1Agt>/Ifngr1 B6.129S7-Ifngr1/J 19734231