Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

IKBKG

External links	Primary Information
MGI:1338074 ENSMUSG00000004221	Gene Symbol	Ikbkg
	Affected Anatomical Systems	adipose tissue phenotype,behavior/neurological phenotype,cellular phenotype,growth/size phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,lethality-postnatal,lethality-prenatal/perinatal,liver/biliary system phenotype,reproductive system phenotype,skin/coat/nails phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3808877 Ikbkgm1Btlr Chemically induced (ENU) mutation 1, Bruce Beutler MGI:4355682 Ikbkgtm1.1Chtr Targeted (Floxed/Frt) targeted mutation 1.1, Christian Trautwein 19635861 MGI:2679024 Ikbkgtm1.1Mpa Targeted (Floxed/Frt) targeted mutation 1.1, Manolis Pasparakis 10911992 MGI:3775942 Ikbkgtm1Dwb Targeted (knock-in) targeted mutation 1, Dean Ballard 18490708 MGI:2386267 Ikbkgtm1Mak Targeted (knock-out) targeted mutation 1, Tak Mak 10766741 MGI:3620102 Ikbkgtm1Mka Targeted (knock-out) targeted mutation 1, Michael Karin 10911991 MGI:2386324 Ikbkgtm1Mpa Targeted (knock-out) targeted mutation 1, Manolis Pasparakis 10911992
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Liver Morphology Ikbkgtm1Mka>/Y involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Embryonic Lethality During Organogenesis Ikbkgtm1Mka>/Y involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Increased Hepatocyte Apoptosis Ikbkgtm1Mka>/Y involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Postnatal Lethality Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Abnormal Locomotor Activity Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Decreased Body Weight Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Tremors Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Sparse Hair Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Abnormal Bone Marrow Cell Morphology/development Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Small Spleen Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Hyperkeratosis Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Small Thymus Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Increased Apoptosis Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Parakeratosis Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Erythroderma Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Increased Hepatocyte Apoptosis Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Absent Megakaryocytes Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Absent Subcutaneous Adipose Tissue Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Increased Keratinocyte Apoptosis Ikbkgtm1Mka>/Ikbkg<+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 10911991 Abnormal Humoral Immune Response Ikbkgtm1Dwb>/Ikbkg Not Specified 18490708 Decreased Tumor Necrosis Factor Secretion Ikbkgtm1Dwb>/Ikbkg Not Specified 18490708 Decreased Interleukin-12b Secretion Ikbkgtm1Dwb>/Ikbkg Not Specified 18490708 Decreased Interleukin-6 Secretion Ikbkgtm1Dwb>/Ikbkg Not Specified 18490708 Abnormal Chemokine Secretion Ikbkgtm1Dwb>/Ikbkg Not Specified 18490708 Decreased Susceptibility To Endotoxin Shock Ikbkgtm1Dwb>/Ikbkg Not Specified 18490708 Reduced Female Fertility Ikbkgm1Btlr>/Ikbkg<+ C57BL/6J-Ikbkg Azoospermia Ikbkgm1Btlr>/Y C57BL/6J-Ikbkg Decreased Regulatory T Cell Number Ikbkgm1Btlr>/Y C57BL/6J-Ikbkg Decreased Tumor Necrosis Factor Secretion Ikbkgm1Btlr>/Y C57BL/6J-Ikbkg Increased Apoptosis Ikbkgtm1Mpa>/Y involves: C57BL/6 10911992 Decreased Tumor Necrosis Factor Secretion Ikbkgtm1Mpa>/Y involves: C57BL/6 10911992 Decreased Interleukin-6 Secretion Ikbkgtm1Mpa>/Y involves: C57BL/6 10911992 Embryonic Lethality Ikbkgtm1Mpa>/Y involves: C57BL/6 10911992 Postnatal Lethality Ikbkgtm1Mpa>/Ikbkg<+ involves: C57BL/6 10911992 Retarded Hair Growth Ikbkgtm1Mpa>/Ikbkg<+ involves: C57BL/6 10911992 Abnormal Epidermis Stratum Basale Morphology Ikbkgtm1Mpa>/Ikbkg<+ involves: C57BL/6 10911992 Thickened Epidermis Ikbkgtm1Mpa>/Ikbkg<+ involves: C57BL/6 10911992 Scaly Skin Ikbkgtm1Mpa>/Ikbkg<+ involves: C57BL/6 10911992 Postnatal Growth Retardation Ikbkgtm1Mpa>/Ikbkg<+ involves: C57BL/6 10911992 Abnormal Epidermis Suprabasal Layer Morphology Ikbkgtm1Mpa>/Ikbkg<+ involves: C57BL/6 10911992 Abnormal Keratinocyte Morphology Ikbkgtm1Mpa>/Ikbkg<+ involves: C57BL/6 10911992 Parakeratosis Ikbkgtm1Mpa>/Ikbkg<+ involves: C57BL/6 10911992 Skin Inflammation Ikbkgtm1Mpa>/Ikbkg<+ involves: C57BL/6 10911992 Abnormal Dermal Pigmentation Ikbkgtm1Mpa>/Ikbkg<+ involves: C57BL/6 10911992 Abnormal Epidermal Pigmentation Ikbkgtm1Mpa>/Ikbkg<+ involves: C57BL/6 10911992 Increased Keratinocyte Apoptosis Ikbkgtm1Mpa>/Ikbkg<+ involves: C57BL/6 10911992 Increased Apoptosis Ikbkgtm1Mak>/Y involves: 129P2/OlaHsd * C57BL/6 10766741 Embryonic Lethality During Organogenesis Ikbkgtm1Mak>/Y involves: 129P2/OlaHsd * C57BL/6 10766741 Liver Hemorrhage Ikbkgtm1Mak>/Y involves: 129P2/OlaHsd * C57BL/6 10766741 Increased Hepatocyte Apoptosis Ikbkgtm1Mak>/Y involves: 129P2/OlaHsd * C57BL/6 10766741 Increased Interleukin-6 Secretion Ikbkgtm1Mak>/Y involves: 129P2/OlaHsd * C57BL/6 10766741 No Abnormal Phenotype Detected Ikbkgtm1.1Chtr>/Ikbkg involves: C57BL/6 * SJL 19635861