Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

IL12B

External links	Primary Information
MGI:96540 ENSMUSG00000004296	Gene Symbol	Il12b
	Affected Anatomical Systems	digestive/alimentary phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:1857201 Il12btm1Jm Targeted (knock-out) targeted mutation 1, Jeanne Magram 8630732 MGI:3663346 Il12btm1Lky Targeted (Reporter) targeted mutation 1, Richard M Locksley 16849470 MGI:3663352 Il12btm2Lky Targeted (Reporter) targeted mutation 2, Richard M Locksley 16849470
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Granulocyte Physiology Il12btm1Jm>/Il12b B6.129S1-Il12b/J 16688182 Increased Susceptibility To Bacterial Infection Il12btm1Jm>/Il12b B6.129S1-Il12b/J 17351619 Abnormal Macrophage Physiology Il12btm1Jm>/Il12b B6.129S1-Il12b/J 16688182 Abnormal NK Cell Physiology Il12btm1Jm>/Il12b B6.129S1-Il12b/J 17351619 Decreased Susceptibility To Type IV Hypersensitivity Reaction Il12btm1Jm>/Il12b B6.129S1-Il12b/J 17351619 Abnormal Lymphocyte Physiology Il12btm1Jm>/Il12b B6.129S1-Il12b/J 17351619 Abnormal CD8-positive T Cell Physiology Il12btm1Jm>/Il12b B6.129S1-Il12b/J 16688182 Decreased Incidence Of Chemically-induced Tumors Il12btm1Jm>/Il12b B6.129S1-Il12b/J 16688182 Decreased Circulating Interferon-gamma Level Il12btm1Jm>/Il12b B6.129S1-Il12b/J 17351619 Decreased Interleukin-17 Secretion Il12btm1Jm>/Il12b B6.129S1-Il12b/J 16688182 Increased Susceptibility To Parasitic Infection Il12btm1Jm>/Il12b 129S1/Sv-Il12b 8766560 Abnormal CD4-positive T Cell Physiology Il12btm1Jm>/Il12b 129S1/Sv-Il12b 8766560 Decreased Susceptibility To Type IV Hypersensitivity Reaction Il12btm1Jm>/Il12b 129S1/Sv-Il12b 8766560 Abnormal Dendritic Cell Physiology Il12btm1Lky>/Il12b involves: 129S4/SvJae * BALB/c * C57BL/6 16849470 Increased T Cell Proliferation Il12btm1Lky>/Il12b involves: 129S4/SvJae * BALB/c * C57BL/6 16849470 Increased Interleukin-2 Secretion Il12btm1Lky>/Il12b involves: 129S4/SvJae * BALB/c * C57BL/6 16849470 Abnormal Dendritic Cell Physiology Il12btm2Lky>/Il12b involves: 129/Sv * BALB/c * C57BL/6 16849470 Abnormal T Cell Proliferation Il12btm2Lky>/Il12b involves: 129/Sv * BALB/c * C57BL/6 16849470 Impaired NK Cell Cytolysis Il12btm1Jm>/Il12b involves: 129S1/SvImJ 9529155 Abnormal T-helper 1 Physiology Il12btm1Jm>/Il12b involves: 129S1/SvImJ 9529155 Decreased Interferon-gamma Secretion Il12btm1Jm>/Il12b involves: 129S1/SvImJ 9529155