Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

BTK

External links	Primary Information
MGI:88216 ENSMUSG00000031264	Gene Symbol	Btk
	Affected Anatomical Systems	digestive/alimentary phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:2449487 Btktm1Gsv Targeted (Reporter) targeted mutation 1, Frank Grosveld 8890160 MGI:3612416 Btktm1Witt Targeted (knock-in) targeted mutation 1, Owen N Witte 16291652 MGI:1857138 Btktm1Wk Targeted (knock-out) targeted mutation 1, Wasif Kahn 7552994 MGI:1856317 Btkxid Spontaneous X linked immune deficiency 7365241
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Immune System Physiology Btktm1Gsv>/Y involves: 129P2/OlaHsd * C57BL/6 8890160 Abnormal Humoral Immune Response Btktm1Gsv>/Y involves: 129P2/OlaHsd * C57BL/6 14634110 Abnormal B Cell Physiology Btktm1Gsv>/Y involves: 129P2/OlaHsd * C57BL/6 15331445 Abnormal B Cell Differentiation Btktm1Gsv>/Y involves: 129P2/OlaHsd * C57BL/6 8890160 Decreased Immunoglobulin Level Btktm1Gsv>/Y involves: 129P2/OlaHsd * C57BL/6 14634110 Decreased IgM Level Btktm1Gsv>/Y involves: 129P2/OlaHsd * C57BL/6 8890160 Decreased B Cell Number Btktm1Gsv>/Y involves: 129P2/OlaHsd * C57BL/6 8890160 Absent B-1a Cells Btktm1Gsv>/Y involves: 129P2/OlaHsd * C57BL/6 8890160 Absent Mature B Cells Btktm1Gsv>/Y involves: 129P2/OlaHsd * C57BL/6 8890160 Decreased Immature B Cell Number Btktm1Gsv>/Y involves: 129P2/OlaHsd * C57BL/6 8890160 Decreased IgG3 Level Btktm1Gsv>/Y involves: 129P2/OlaHsd * C57BL/6 8890160 Abnormal B Cell Differentiation Btktm1Wk>/Btk involves: 129S4/SvJae * C57BL/6 7552994 Decreased IgM Level Btktm1Wk>/Btk involves: 129S4/SvJae * C57BL/6 7552994,9088978 Decreased B Cell Proliferation Btktm1Wk>/Btk involves: 129S4/SvJae * C57BL/6 9088978 Increased Pro-B Cell Number Btktm1Wk>/Btk involves: 129S4/SvJae * C57BL/6 7552994 Decreased Mature B Cell Number Btktm1Wk>/Btk involves: 129S4/SvJae * C57BL/6 7552994,9088978 Abnormal B Cell Activation Btktm1Wk>/Btk involves: 129S4/SvJae * C57BL/6 7552994 Decreased Spleen Germinal Center Number Btktm1Wk>/Btk involves: 129S4/SvJae * C57BL/6 9088978 Decreased Spleen Germinal Center Size Btktm1Wk>/Btk involves: 129S4/SvJae * C57BL/6 9088978 Decreased IgG3 Level Btktm1Wk>/Btk involves: 129S4/SvJae * C57BL/6 7552994,9088978 Abnormal Lymph Node Germinal Center Btktm1Wk>/Btk involves: 129S4/SvJae * C57BL/6 9088978 Impaired Myelopoiesis Btkxid>/Btk CBA/CaHN-Btk/J 15117762 Impaired Neutrophil Phagocytosis Btkxid>/Btk CBA/CaHN-Btk/J 15117762 Abnormal Macrophage Physiology Btkxid>/Btk CBA/CaHN-Btk/J 15117762 Abnormal Neutrophil Physiology Btkxid>/Btk CBA/CaHN-Btk/J 15117762 Decreased Neutrophil Cell Number Btkxid>/Btk CBA/CaHN-Btk/J 15117762 Decreased Acute Inflammation Btkxid>/Btk CBA/CaHN-Btk/J 15117762 Decreased Susceptibility To Experimental Autoimmune Encephalomyelitis Btkxid>/Btk CBA/CaHN-Btk/J 15117762 Increased Susceptibility To Induced Colitis Btkxid>/Btk CBA/CaHN-Btk/J 15117762 Decreased B Cell Number Btkxid>/Y CBA/HN-Btk 805203 Decreased B Cell Proliferation Btkxid>/Y CBA/HN-Btk 805203 Decreased Splenocyte Number Btkxid>/Y CBA/HN-Btk 805203 Abnormal B Cell Physiology Btkxid>/Btk involves: CBA/HN * DBA/2N 805203 Spleen Hypoplasia Btkxid>/Btk involves: CBA/HN * DBA/2N 805203 Decreased B Cell Number Btkxid>/Btk involves: CBA/HN * DBA/2N 805203 Abnormal B Cell Proliferation Btkxid>/Btk involves: CBA/HN * DBA/2N 805203 Spleen Hypoplasia Btkxid>/Y involves: CBA/HN * DBA/2N 805203 Decreased B Cell Number Btkxid>/Y involves: CBA/HN * DBA/2N 805203 Decreased B Cell Proliferation Btkxid>/Y involves: CBA/HN * DBA/2N 805203 Abnormal Bone Marrow Cell Number Btkxid>/Btk CBA/HN-Btk 3875649 Abnormal Lymphopoiesis Btkxid>/Btk CBA/HN-Btk 3875649 Autoimmune Response Btkxid>/Btk CBA/HN-Btk 17574818 Abnormal Pre-B Cell Morphology Btkxid>/Btk CBA/HN-Btk 3875649 Decreased B Cell Number Btkxid>/Btk CBA/HN-Btk 805203 Decreased B Cell Proliferation Btkxid>/Btk CBA/HN-Btk 805203 Decreased Splenocyte Number Btkxid>/Btk CBA/HN-Btk 805203 Decreased B Cell Number Btktm1Gsv>/Btk<+ involves: 129P2/OlaHsd * C57BL/6 8890160 Absent B-1a Cells Btktm1Gsv>/Btk<+ involves: 129P2/OlaHsd * C57BL/6 8890160 Decreased Mature B Cell Number Btktm1Gsv>/Btk<+ involves: 129P2/OlaHsd * C57BL/6 8890160 Decreased IgM Level Btkxid>/? involves: BALB/c * CBA/N 9371815 Decreased B Cell Proliferation Btkxid>/? involves: BALB/c * CBA/N 9371815 Decreased B-1 B Cell Number Btkxid>/? involves: BALB/c * CBA/N 9371815 Decreased Mature B Cell Number Btkxid>/? involves: BALB/c * CBA/N 9371815 Decreased IgG3 Level Btkxid>/? involves: BALB/c * CBA/N 9371815 Decreased Transitional Stage B Cell Number Btkxid>/Btk B6.CBA-Btk 17105816