Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

IL7R

External links	Primary Information
MGI:96562 ENSMUSG00000003882	Gene Symbol	Il7r
	Affected Anatomical Systems	hematopoietic system phenotype,immune system phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3758859 Il7rtm1Abra Targeted (knock-in) targeted mutation 1, Ninan Abraham 17325202 MGI:3038693 Il7rtm1Iku Targeted (knock-out) targeted mutation 1, Koichi Ikuta 8692964 MGI:1857198 Il7rtm1Imx Targeted (knock-out) targeted mutation 1, Immunex 7964471
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Thymus Hypoplasia Il7rtm1Imx>/Il7r involves: 129P3/J * 129S7/SvEvBrd 7964471 Spleen Hypoplasia Il7rtm1Imx>/Il7r involves: 129P3/J * 129S7/SvEvBrd 7964471 Arrested B Cell Differentiation Il7rtm1Imx>/Il7r involves: 129P3/J * 129S7/SvEvBrd 7964471 Arrested T Cell Differentiation Il7rtm1Imx>/Il7r involves: 129P3/J * 129S7/SvEvBrd 7964471 Decreased B Cell Number Il7rtm1Imx>/Il7r involves: 129P3/J * 129S7/SvEvBrd 7964471 Decreased T Cell Number Il7rtm1Imx>/Il7r involves: 129P3/J * 129S7/SvEvBrd 7964471 Lymph Node Hypoplasia Il7rtm1Imx>/Il7r involves: 129P3/J * 129S7/SvEvBrd 7964471 Thymus Hypoplasia Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Decreased Bone Marrow Cell Number Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Abnormal B Cell Differentiation Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Decreased Leukocyte Cell Number Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Spleen Hypoplasia Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Small Thymus Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Decreased Lymphocyte Cell Number Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Decreased T Cell Number Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Increased Double-negative T Cell Number Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Decreased Double-positive T Cell Number Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Absent Peyer's Patches Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 9488150 Abnormal T Cell Subpopulation Ratio Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Decreased B-1 B Cell Number Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Decreased Mature B Cell Number Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Decreased Immature B Cell Number Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Absent Mature Gamma-delta T Cells Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Abnormal Gamma-delta T Cell Differentiation Il7rtm1Iku>/Il7r involves: 129P2/OlaHsd * C57BL/6J 8692964 Abnormal T Cell Differentiation Il7rtm1Imx>/Il7r B6.129S7-Il7r 17325202 Decreased Thymocyte Number Il7rtm1Imx>/Il7r B6.129S7-Il7r 17325202 Decreased Double-positive T Cell Number Il7rtm1Imx>/Il7r B6.129S7-Il7r 17325202 Abnormal T Cell Differentiation Il7rtm1Abra>/Il7r B6.129S4-Il7r 17325202 Decreased Thymocyte Number Il7rtm1Abra>/Il7r B6.129S4-Il7r 17325202 Decreased B Cell Number Il7rtm1Abra>/Il7r B6.129S4-Il7r 17325202 Abnormal T Cell Proliferation Il7rtm1Abra>/Il7r B6.129S4-Il7r 17325202 Increased Double-positive T Cell Number Il7rtm1Abra>/Il7r B6.129S4-Il7r 17325202 Abnormal CD4-positive T Cell Physiology Il7rtm1Abra>/Il7r B6.129S4-Il7r 17325202 Decreased Memory T Cell Number Il7rtm1Abra>/Il7r B6.129S4-Il7r 17325202 Decreased CD4-positive T Cell Number Il7rtm1Abra>/Il7r B6.129S4-Il7r 17325202 Decreased CD8-positive T Cell Number Il7rtm1Abra>/Il7r B6.129S4-Il7r 17325202 Decreased Thymocyte Number Il7rtm1Imx>/Il7r involves: 129S7/SvEvBrd 11034372