LIG4
Primary Info
Mutation
Mouse studies
DNA sequencing


External links Primary Information
MGI:1335098
ENSMUSG00000049717		 Gene Symbol Lig4
Affected Anatomical Systems cellular phenotype,digestive/alimentary phenotype,embryogenesis phenotype,growth/size phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,lethality-prenatal/perinatal,life span-post-weaning/aging,nervous system phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id
MGI:3714783 Lig4tiny Chemically induced (ENU) tiny
MGI:1857732 Lig4tm1Fwa Targeted (knock-out) targeted mutation 1, Frederick W Alt 9823897
MGI:1857720 Lig4tm1Icrf Targeted (knock-out) targeted mutation 1, Imperial Cancer Research Fund 9889105
MGI:3831168 Lig4tm1Pmc Targeted (Floxed/Frt) targeted mutation 1, Peter J McKinnon 19171781
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id
Prenatal Lethality Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac * C57BL/6 12531011
Increased Cellular Sensitivity To Gamma-irradiation Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac * C57BL/6 9823897
Decreased Cell Proliferation Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac * C57BL/6 9823897
Abnormal Lymphopoiesis Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac * C57BL/6 9823897
Abnormal B Cell Differentiation Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac * C57BL/6 9823897
Abnormal T Cell Differentiation Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac * C57BL/6 10911993
Small Thymus Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac * C57BL/6 9823897
Decreased Thymocyte Number Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac * C57BL/6 10911993
Arrested B Cell Differentiation Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac * C57BL/6 10911993
Arrested T Cell Differentiation Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac * C57BL/6 9823897
Abnormal Cell Physiology Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac * C57BL/6 9823897
Lethality Throughout Fetal Growth And Development Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac * C57BL/6 9823897
Chromosome Breakage Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac * C57BL/6 12531011
Decreased Fetal Size Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac * C57BL/6 9823897
Abnormal Embryonic Tissue Morphology Lig4tm1Icrf>/Lig4 involves: 129 9889105
Prenatal Lethality Lig4tm1Icrf>/Lig4 involves: 129 9889105
Increased Neuron Apoptosis Lig4tm1Icrf>/Lig4 either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ) 11040211,16777961,9889105
Lethality Throughout Fetal Growth And Development Lig4tm1Icrf>/Lig4 either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ) 9889105
Chromosome Breakage Lig4tm1Fwa>/Lig4<+ involves: 129S6/SvEvTac * C57BL/6 12531011
Decreased Body Size Lig4tiny>/Lig4 C57BL/6JApb-Lig4/Apb 17554302
Prenatal Lethality Lig4tiny>/Lig4 C57BL/6JApb-Lig4/Apb 17554302
Decreased Cell Proliferation Lig4tiny>/Lig4 C57BL/6JApb-Lig4/Apb 17554302
Decreased Bone Marrow Cell Number Lig4tiny>/Lig4 C57BL/6JApb-Lig4/Apb 17554302
Postnatal Growth Retardation Lig4tiny>/Lig4 C57BL/6JApb-Lig4/Apb 17554302
Absent CD8-positive T Cells Lig4tiny>/Lig4 C57BL/6JApb-Lig4/Apb
Abnormal Proerythroblast Morphology Lig4tiny>/Lig4 C57BL/6JApb-Lig4/Apb 17554302
Decreased Lymphocyte Cell Number Lig4tiny>/Lig4 C57BL/6JApb-Lig4/Apb 17554302
Decreased B Cell Number Lig4tiny>/Lig4 C57BL/6JApb-Lig4/Apb 17554302
Decreased Hematopoietic Stem Cell Number Lig4tiny>/Lig4 C57BL/6JApb-Lig4/Apb 17554302
Abnormal DNA Repair Lig4tiny>/Lig4 C57BL/6JApb-Lig4/Apb 17554302
Induced Chromosome Breakage Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac 18854157
Increased Cellular Sensitivity To Ionizing Radiation Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac 18854157
Chromosomal Instability Lig4tm1Fwa>/Lig4 involves: 129S6/SvEvTac 18854157
Abnormal Immune System Physiology Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Abnormal Immune System Morphology Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased Body Size Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Premature Death Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Increased Cellular Sensitivity To Gamma-irradiation Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Abnormal Immune System Cell Morphology Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased Body Weight Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Reduced Fertility Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Abnormal Thymus Morphology Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Abnormal Lymphocyte Cell Number Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Postnatal Growth Retardation Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Abnormal B Cell Differentiation Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Abnormal T Cell Differentiation Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Intestinal Inflammation Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Liver Inflammation Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Small Spleen Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Abnormal T Cell Activation Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased Immunoglobulin Level Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Small Thymus Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased Thymocyte Number Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased IgA Level Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased IgG Level Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased IgM Level Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased B Cell Number Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Abnormal Immune System Organ Morphology Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased T Cell Proliferation Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased Double-negative T Cell Number Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased Double-positive T Cell Number Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Thymic Lymphoma Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Abnormal Cell Physiology Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Spontaneous Chromosome Breakage Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Medulloblastoma Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Increased Anti-double Stranded DNA Antibody Level Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Increased Anti-chromatin Antibody Level Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Abnormal Regulatory T Cell Morphology Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased Spleen Weight Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased Thymus Weight Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased CD4-positive T Cell Number Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased CD8-positive T Cell Number Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Abnormal B Cell Activation Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased IgG2b Level Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased IgG3 Level Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased Interferon-gamma Secretion Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased Interleukin-13 Secretion Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Abnormal T Cell Receptor V(D)J Recombination Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Abnormal T Cell Receptor Beta Chain V(D)J Recombination Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Increased T Cell Apoptosis Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Chromosomal Instability Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Colon Adenocarcinoma Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615
Decreased Splenocyte Number Lig4tm2.1Fwa>/Lig4 involves: 129S6/SvEvTac 20133615