Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

NP

External links	Primary Information
MGI:97365 ENSMUSG00000021871	Gene Symbol	Pnp1
	Affected Anatomical Systems	hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,lethality-prenatal/perinatal,renal/urinary system phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3777967 Pnp1e Chemically induced (ENU) NP-1E 2516826 MGI:3777968 Pnp1f Chemically induced (ENU) NP-1F 2516826 MGI:3777975 Pnp1g Chemically induced (ENU) NP-1G 1781357 MGI:3777976 Pnp1h Chemically induced (ENU) NP-1H 1781357 MGI:3777978 Pnp1i Chemically induced (ENU) NP-1I 1781357 MGI:2386195 Pnp1tm1Cmr Targeted (knock-out) targeted mutation 1, Chaim M Roifman 10859343
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Kidney Excretion Pnp1e>/Pnp1 involves: C3H/HeHa * C57BL/6J 2516826 Abnormal Enzyme/coenzyme Activity Pnp1e>/Pnp1 involves: C3H/HeHa * C57BL/6J 2516826 Thymus Hypoplasia Pnp1e>/Pnp1 C57BL/6J-Pnp1 9122228 Increased Double-negative T Cell Number Pnp1f>/Pnp1 involves: C3H/HeHa * C57BL/6J 1781357 Abnormal Kidney Excretion Pnp1f>/Pnp1 involves: C3H/HeHa * C57BL/6J 2516826 Abnormal Enzyme/coenzyme Activity Pnp1f>/Pnp1 involves: C3H/HeHa * C57BL/6J 2516826 Thymus Hypoplasia Pnp1f>/Pnp1 C57BL/6J-Pnp1 9122228 Abnormal Leukocyte Cell Number Pnp1f>/Pnp1 C57BL/6J-Pnp1 9122228 Decreased Double-positive T Cell Number Pnp1f>/Pnp1 C57BL/6J-Pnp1 9122228 Decreased CD8-positive T Cell Number Pnp1f>/Pnp1 C57BL/6J-Pnp1 9122228 Embryonic Lethality During Organogenesis Pnp1g>/Pnp1 involves: C57BL/6J 1781356 Prenatal Lethality Pnp1g>/Pnp1 involves: C57BL/6 * DBA/2J 1781356 Thymus Hypoplasia Pnp1g>/Pnp1 involves: C57BL/6 * DBA/2J 9122228 Abnormal Leukocyte Cell Number Pnp1g>/Pnp1 involves: C57BL/6 * DBA/2J 9122228 Increased Double-negative T Cell Number Pnp1g>/Pnp1 involves: C57BL/6 * DBA/2J 9122228 Decreased Double-positive T Cell Number Pnp1g>/Pnp1 involves: C57BL/6 * DBA/2J 9122228 Abnormal Enzyme/coenzyme Activity Pnp1g>/Pnp1 involves: C57BL/6 * DBA/2J 1781357 Decreased CD8-positive T Cell Number Pnp1g>/Pnp1 involves: C57BL/6 * DBA/2J 9122228 Abnormal Enzyme/coenzyme Activity Pnp1h>/Pnp1 involves: C3H/HeHa * C57BL/6J 1781357 Abnormal Enzyme/coenzyme Activity Pnp1i>/Pnp1 involves: C3H/HeHa * C57BL/6J 1781357 Increased Cellular Sensitivity To Gamma-irradiation Pnp1tm1Cmr>/Pnp1 involves: 129 10859343 Abnormal Myelopoiesis Pnp1tm1Cmr>/Pnp1 involves: 129 10859343 Defective Cytotoxic T Cell Cytolysis Pnp1tm1Cmr>/Pnp1 involves: 129 10859343 Increased Double-negative T Cell Number Pnp1tm1Cmr>/Pnp1 involves: 129 10859343 Decreased Double-positive T Cell Number Pnp1tm1Cmr>/Pnp1 involves: 129 10859343 Abnormal Enzyme/coenzyme Activity Pnp1tm1Cmr>/Pnp1 involves: 129 10859343 Increased Pre-B Cell Number Pnp1tm1Cmr>/Pnp1 involves: 129 10859343 Abnormal Mitochondrial Physiology Pnp1tm1Cmr>/Pnp1 involves: 129 10859343 Abnormal DNA Repair Pnp1tm1Cmr>/Pnp1 involves: 129 10859343 Decreased CD4-positive T Cell Number Pnp1tm1Cmr>/Pnp1 involves: 129 10859343 Decreased CD8-positive T Cell Number Pnp1tm1Cmr>/Pnp1 involves: 129 10859343 Decreased Single-positive T Cell Number Pnp1tm1Cmr>/Pnp1 involves: 129 10859343 Increased Thymocyte Apoptosis Pnp1tm1Cmr>/Pnp1 involves: 129 10859343 Abnormal Urine Homeostasis Pnp1tm1Cmr>/Pnp1 involves: 129 10859343