Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

RAG1

External links	Primary Information
MGI:97848 ENSMUSG00000061311	Gene Symbol	Rag1
	Affected Anatomical Systems	behavior/neurological phenotype,cardiovascular system phenotype,digestive/alimentary phenotype,endocrine/exocrine gland phenotype,hearing/vestibular/ear phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,life span-post-weaning/aging,liver/biliary system phenotype,nervous system phenotype,normal phenotype,renal/urinary system phenotype,respiratory system phenotype,skeleton phenotype,skin/coat/nails phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3720344 Rag1/Rag2tm1Mnz Targeted (other) targeted mutation 1, Michel C Nussenzweig 15021880 MGI:3851764 Rag1m1Btlr Chemically induced (ENU) mutation 1, Bruce Beutler MGI:3584018 Rag1tm1(cre)Thr Targeted (knock-in) targeted mutation 1, Terence H Rabbitts 14645513 MGI:2388344 Rag1tm1(GFP)Imku Targeted (Reporter) targeted mutation 1, Nobuo Sakaguchi 10586023 MGI:2448994 Rag1tm1Bal Targeted (knock-out) targeted mutation 1, David Baltimore 7926785 MGI:2681693 Rag1tm1Fwa Targeted (knock-in) targeted mutation 1, Frederick W Alt 14581608 MGI:3840831 Rag1tm1Jsek Targeted (knock-in) targeted mutation 1, JoAnne Sekiguchi 19126872 MGI:1857241 Rag1tm1Mom Targeted (knock-out) targeted mutation 1, Peter Mombaerts 1547488
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Thymus Hypoplasia Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * CD-1 1547488 Abnormal Inguinal Lymph Node Morphology Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * CD-1 1547488 Abnormal B Cell Differentiation Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * CD-1 1547488 Abnormal T Cell Differentiation Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * CD-1 1547488 Spleen Hypoplasia Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * CD-1 1547488 Decreased IgM Level Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * CD-1 1547488 Thymus Hypoplasia Rag1tm1Fwa>/Rag1 involves: 129/Sv 14581608 Abnormal B Cell Differentiation Rag1tm1Fwa>/Rag1 involves: 129/Sv 14581608 Abnormal T Cell Differentiation Rag1tm1Fwa>/Rag1 involves: 129/Sv 14581608 Decreased B Cell Number Rag1tm1Fwa>/Rag1 involves: 129/Sv 14581608 Increased Double-negative T Cell Number Rag1tm1Fwa>/Rag1 involves: 129/Sv 14581608 Mixed Cellular Infiltration To Dermis Rag1tm1Mom>/Rag1 B6.129S7-Rag1 16880407 Epidermal Hyperplasia Rag1tm1Mom>/Rag1 B6.129S7-Rag1 16880407 Dermatitis Rag1tm1Mom>/Rag1 B6.129S7-Rag1 16880407 Scaly Skin Rag1tm1Mom>/Rag1 B6.129S7-Rag1 16880407 Thick Skin Rag1tm1Mom>/Rag1 B6.129S7-Rag1 16880407 Ear Inflammation Rag1tm1Mom>/Rag1 B6.129S7-Rag1 16880407 Decreased Immunoglobulin Level Rag1tm1Mom>/Rag1 B6.129S7-Rag1 16880407 Decreased IgM Level Rag1tm1Mom>/Rag1 B6.129S7-Rag1 10066708 Increased Eosinophil Cell Number Rag1tm1Mom>/Rag1 B6.129S7-Rag1 16880407 Decreased Vascular Permeability Rag1tm1Mom>/Rag1 B6.129S7-Rag1 10066708 Abnormal Lymphopoiesis Rag1tm1(cre)Thr>/Rag1 Not Specified 14645513 Absent Lymphocyte Rag1tm1(cre)Thr>/Rag1 Not Specified 14645513 Small Thymus Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD 16804066 Decreased Lymphocyte Cell Number Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD 16804066 Abnormal Double-negative T Cell Morphology Rag1/Rag2tm1Mnz>/Rag1/Rag2 involves: 129P2/OlaHsd * C57BL/6 15021880 Abnormal Double-positive T Cell Morphology Rag1/Rag2tm1Mnz>/Rag1/Rag2 involves: 129P2/OlaHsd * C57BL/6 15021880 Decreased T Cell Number Rag1/Rag2tm1Mnz>/Rag1/Rag2 involves: 129P2/OlaHsd * C57BL/6 15021880 Abnormal T Cell Morphology Rag1/Rag2tm1Mnz>/Rag1/Rag2 involves: 129P2/OlaHsd * C57BL/6 15021880 Increased Granulocyte Number Rag1tm1Mom>/Rag1 NOD.129S7(B6)-Rag1 14557749 Spleen Hypoplasia Rag1tm1Mom>/Rag1 NOD.129S7(B6)-Rag1 14557749 Decreased Immunoglobulin Level Rag1tm1Mom>/Rag1 NOD.129S7(B6)-Rag1 14557749 Abnormal Level Of Surface Class II Molecules Rag1tm1Mom>/Rag1 NOD.129S7(B6)-Rag1 14557749 Impaired NK Cell Cytolysis Rag1tm1Mom>/Rag1 NOD.129S7(B6)-Rag1 14557749 Increased Macrophage Cell Number Rag1tm1Mom>/Rag1 NOD.129S7(B6)-Rag1 14557749 Increased NK Cell Number Rag1tm1Mom>/Rag1 NOD.129S7(B6)-Rag1 14557749 Decreased CD4-positive T Cell Number Rag1tm1Mom>/Rag1 NOD.129S7(B6)-Rag1 14557749 Decreased CD8-positive T Cell Number Rag1tm1Mom>/Rag1 NOD.129S7(B6)-Rag1 14557749 Decreased Mature B Cell Number Rag1tm1Mom>/Rag1 NOD.129S7(B6)-Rag1 14557749 Increased Immature B Cell Number Rag1tm1Mom>/Rag1 NOD.129S7(B6)-Rag1 14557749 Abnormal Coat/hair Pigmentation Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * C57BL/6 18354038 Abnormal Respiratory System Morphology Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * C57BL/6 16272283 Abnormal Skin Pigmentation Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * C57BL/6 18354038 Abnormal Eye Morphology Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * C57BL/6 18354038 Abnormal Lymphatic Vessel Morphology Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * C57BL/6 16272283 Abnormal Retina Morphology Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * C57BL/6 18354038 Autoimmune Response Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * C57BL/6 18354038 Decreased Neutrophil Cell Number Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * C57BL/6 16272283 Abnormal Response To Infection Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * C57BL/6 16272283 Abnormal Bone Remodeling Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd * C57BL/10 17611620 Abnormal Immunoglobulin V(D)J Recombination Rag1tm1(GFP)Imku>/Rag1 involves: C57BL/6 * CBA 10586023 Abnormal Lymphopoiesis Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Thymus Hypoplasia Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Abnormal Immunoglobulin Level Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Arrested B Cell Differentiation Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Arrested T Cell Differentiation Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Increased Double-negative T Cell Number Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Decreased Double-positive T Cell Number Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Spontaneous Chromosome Breakage Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Decreased CD4-positive T Cell Number Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Decreased CD8-positive T Cell Number Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Increased Pro-B Cell Number Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Absent Mature B Cells Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Absent Immature B Cells Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Decreased Gamma-delta T Cell Number Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Abnormal T Cell Receptor V(D)J Recombination Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Abnormal T Cell Receptor Beta Chain V(D)J Recombination Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Abnormal Immunoglobulin Heavy Chain V(D)J Recombination Rag1tm1Jsek>/Rag1 involves: 129S6/SvEvTac 19126872 Abnormal B Cell Differentiation Rag1tm1Jsek>/Rag1<+ involves: 129S6/SvEvTac 19126872 Abnormal T Cell Differentiation Rag1tm1Jsek>/Rag1<+ involves: 129S6/SvEvTac 19126872 Decreased Double-positive T Cell Number Rag1tm1Jsek>/Rag1<+ involves: 129S6/SvEvTac 19126872 Abnormal T Cell Receptor Beta Chain V(D)J Recombination Rag1tm1Jsek>/Rag1<+ involves: 129S6/SvEvTac 19126872 Abnormal Immunoglobulin Heavy Chain V(D)J Recombination Rag1tm1Jsek>/Rag1<+ involves: 129S6/SvEvTac 19126872 Abnormal Double-negative T Cell Morphology Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd 7520000 Abnormal Thymus Epithelium Morphology Rag1tm1Mom>/Rag1 involves: 129S7/SvEvBrd 17502664 Absent Late Pro-B Cells Rag1m1Btlr>/Rag1 C57BL/6J-Rag1 Decreased CD4-positive T Cell Number Rag1m1Btlr>/Rag1 C57BL/6J-Rag1 Decreased CD8-positive T Cell Number Rag1m1Btlr>/Rag1 C57BL/6J-Rag1 Arrested B Cell Differentiation Rag1tm1.1Sadu>/Rag1 involves: BALB/c 19812384