Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

TLR3

External links	Primary Information
MGI:2156367 ENSMUSG00000031639	Gene Symbol	Tlr3
	Affected Anatomical Systems	immune system phenotype,muscle phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:2653138 Tlr3tm1Flv Targeted (knock-out) targeted mutation 1, Richard A Flavell 11607032 MGI:3690535 Tlr3tm1Ttg Targeted (knock-out) targeted mutation 1, Tadatsugu Taniguchi 12960379
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal B Cell Physiology Tlr3tm1Flv>/Tlr3 involves: 129S1/Sv * C57BL/6 11607032 Decreased Inflammatory Response Tlr3tm1Flv>/Tlr3 involves: 129S1/Sv * C57BL/6 11607032 Abnormal Macrophage Physiology Tlr3tm1Flv>/Tlr3 involves: 129S1/Sv * C57BL/6 11607032 Abnormal Macrophage Physiology Tlr3tm1Flv>/Tlr3 involves: C57BL/6 14625548 Increased Susceptibility To Viral Infection Tlr3tm1Flv>/Tlr3 Not Specified 14993594 Abnormal NK Cell Physiology Tlr3tm1Flv>/Tlr3 Not Specified 14993594 Abnormal Cytokine Secretion Tlr3tm1Flv>/Tlr3 Not Specified 14993594 Abnormal NK T Cell Physiology Tlr3tm1Flv>/Tlr3 Not Specified 14993594 Abnormal Dendritic Cell Physiology Tlr3tm1Ttg>/Tlr3 involves: 129P2/OlaHsd 12960379 Abnormal Vascular Smooth Muscle Physiology Tlr3tm1Ttg>/Tlr3 involves: 129P2/OlaHsd 16782847