Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

AICDA

External links	Primary Information
MGI:1342279 ENSMUSG00000040627	Gene Symbol	Aicda
	Affected Anatomical Systems	cellular phenotype,hematopoietic system phenotype,immune system phenotype,no phenotypic analysis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3720568 Aicdatm1(cre)Mnz Targeted (knock-in) targeted mutation 1, Michel C Nussenzweig MGI:2156156 Aicdatm1Hon Targeted (knock-out) targeted mutation 1, Tasuku Honjo 11007474 MGI:3693885 Aicdatm1Tsuz Targeted (knock-in) targeted mutation 1, Toshiharu Suzuki 16716194 MGI:3796170 Aicdatm2Mnz Targeted (knock-in) targeted mutation 2, Michel C Nussenzweig 18455451 MGI:3839329 Aicdatm3.1Mnz Targeted (knock-in) targeted mutation 3.1, Michel C Nussenzweig MGI:3818466 Aicdatm3Mnz Targeted (knock-in) targeted mutation 3, Michel C Nussenzweig 18838546 MGI:3839323 Aicdatm4.1Mnz Targeted (knock-in) targeted mutation 4.1, Michel C Nussenzweig MGI:3818467 Aicdatm4Mnz Targeted (knock-in) targeted mutation 4, Michel C Nussenzweig 18838546
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Increased IgM Level Aicdatm1Hon>/Aicda involves: C57BL/6 * CBA 11007474 Abnormal Somatic Hypermutation Frequency Aicdatm1Hon>/Aicda involves: C57BL/6 * CBA 18455451,18838546 Abnormal Class Switch Recombination Aicdatm1Hon>/Aicda involves: C57BL/6 * CBA 11007474,12810694,18838546 Decreased IgG1 Level Aicdatm1Hon>/Aicda involves: C57BL/6 * CBA 11007474 Decreased IgG2a Level Aicdatm1Hon>/Aicda involves: C57BL/6 * CBA 11007474 Chromosomal Instability Aicdatm2Mnz>/Aicda C57BL/6-Aicda 18455451 Chromosomal Instability Aicdatm1Hon>/Aicda involves: C57BL/6 * CBA 18455451 Abnormal Somatic Hypermutation Frequency Aicdatm1Hon>/Aicda<+ involves: C57BL/6 * CBA 18838546 Abnormal Class Switch Recombination Aicdatm1Hon>/Aicda<+ involves: C57BL/6 * CBA 18455451,18838546 Abnormal Somatic Hypermutation Frequency Aicdatm3Mnz>/Aicda<+ involves: C57BL/6 * CBA 18838546 Abnormal Class Switch Recombination Aicdatm3Mnz>/Aicda<+ involves: C57BL/6 * CBA 18838546 Abnormal Somatic Hypermutation Frequency Aicdatm4Mnz>/Aicda<+ involves: C57BL/6 * CBA 18838546 Abnormal Class Switch Recombination Aicdatm4Mnz>/Aicda<+ involves: C57BL/6 * CBA 18838546 Abnormal Somatic Hypermutation Frequency Aicdatm1Hon>/Aicda involves: C57BL/6 * CBA 18838546 Abnormal Class Switch Recombination Aicdatm1Hon>/Aicda involves: C57BL/6 * CBA 18838546 Abnormal Somatic Hypermutation Frequency Aicdatm1Hon>/Aicda involves: C57BL/6 * CBA 18838546 Abnormal Class Switch Recombination Aicdatm1Hon>/Aicda involves: C57BL/6 * CBA 18838546 Abnormal Somatic Hypermutation Frequency Aicdatm3.1Mnz>/Aicda involves: C57BL/6 Abnormal Class Switch Recombination Aicdatm3.1Mnz>/Aicda involves: C57BL/6 Abnormal Somatic Hypermutation Frequency Aicdatm4.1Mnz>/Aicda involves: C57BL/6 Abnormal Class Switch Recombination Aicdatm4.1Mnz>/Aicda involves: C57BL/6