Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

ICOS

External links	Primary Information
MGI:1858745 ENSMUSG00000026009	Gene Symbol	Icos
	Affected Anatomical Systems	digestive/alimentary phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3719635 Icostm1Dgry Targeted (knock-out) targeted mutation 1, David Gray 17549732 MGI:2683635 Icostm1Flv Targeted (knock-out) targeted mutation 1, Richard A Flavell 11343121 MGI:2445839 Icostm1Mak Targeted (knock-out) targeted mutation 1, Tak Mak 11343123 MGI:2683665 Icostm1Shr Targeted (knock-out) targeted mutation 1, Arlene H Sharpe 11343122 MGI:3526880 Icostm1Tkan Targeted (knock-out) targeted mutation 1, T Kanai 12853164
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Immune System Physiology Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 11343123 Abnormal Spleen Morphology Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 11343123 Abnormal B Cell Physiology Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 11343123 Abnormal T Cell Physiology Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 11343123 Abnormal B Cell Number Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 19915142 Abnormal Peyer's Patch Germinal Center Morphology Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 19915142 Decreased IgA Level Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 19915142 Decreased IgE Level Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 11343123 Decreased T Cell Proliferation Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 11343123 Abnormal Class Switch Recombination Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 11343123 Decreased CD4-positive T Cell Number Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 19915142 Small Peyer's Patches Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 19915142 Decreased Spleen Germinal Center Number Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 11343123,19915142 Decreased Spleen Germinal Center Size Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 11343123 Decreased IgG1 Level Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 11343123,19915142 Decreased IgG2b Level Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 19915142 Decreased IgG2c Level Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 19915142 Decreased Interleukin-21 Secretion Icostm1Mak>/Icos involves: 129P2/OlaHsd * C57BL/6 19915142 Abnormal Immunoglobulin Level Icostm1Flv>/Icos involves: 129/Sv * C57BL/6 11343121 Small Lymph Nodes Icostm1Flv>/Icos involves: 129/Sv * C57BL/6 11343121 Decreased IgE Level Icostm1Flv>/Icos involves: 129/Sv * C57BL/6 11343121 Abnormal T-helper 2 Physiology Icostm1Flv>/Icos involves: 129/Sv * C57BL/6 11343121 Increased Susceptibility To Experimental Autoimmune Encephalomyelitis Icostm1Flv>/Icos involves: 129/Sv * C57BL/6 11343121 Decreased IgG1 Level Icostm1Flv>/Icos involves: 129/Sv * C57BL/6 11343121 Abnormal Interferon Level Icostm1Flv>/Icos involves: 129/Sv * C57BL/6 11343121 Abnormal Interleukin Level Icostm1Flv>/Icos involves: 129/Sv * C57BL/6 11343121 Abnormal Immunoglobulin Level Icostm1Shr>/Icos Not Specified 11343122 Abnormal T Cell Differentiation Icostm1Shr>/Icos Not Specified 11343122 Abnormal Spleen Germinal Center Morphology Icostm1Shr>/Icos Not Specified 11343122 Decreased IgE Level Icostm1Shr>/Icos Not Specified 11343122 Decreased IgG Level Icostm1Shr>/Icos Not Specified 11343122 Abnormal CD4-positive T Cell Physiology Icostm1Shr>/Icos Not Specified 11343122 Decreased IgG1 Level Icostm1Shr>/Icos Not Specified 11343122 Decreased IgG2a Level Icostm1Shr>/Icos Not Specified 11343122 Increased IgG3 Level Icostm1Shr>/Icos Not Specified 11343122 Abnormal Interleukin Level Icostm1Shr>/Icos Not Specified 11343122 Abnormal Small Intestine Morphology Icostm1Tkan>/Icos involves: 129S7/SvEvBrd * C57BL/6 12853164 Abnormal Peyer's Patch Germinal Center Morphology Icostm1Tkan>/Icos involves: 129S7/SvEvBrd * C57BL/6 12853164 Small Peyer's Patches Icostm1Tkan>/Icos involves: 129S7/SvEvBrd * C57BL/6 12853164 Abnormal NK Cell Physiology Icostm1Tkan>/Icos involves: C57BL/6 15629449 Decreased Circulating Interferon-gamma Level Icostm1Tkan>/Icos involves: C57BL/6 15629449 Decreased Circulating Interleukin-4 Level Icostm1Tkan>/Icos involves: C57BL/6 15629449 Abnormal Immune System Physiology Icostm1Dgry>/Icos B6.129P2-Icos 17549732 Abnormal Leukocyte Cell Number Icostm1Dgry>/Icos B6.129P2-Icos 17549732 Abnormal T Cell Physiology Icostm1Dgry>/Icos B6.129P2-Icos 17549732 Decreased IgG Level Icostm1Dgry>/Icos B6.129P2-Icos 17549732 Abnormal Response To Infection Icostm1Dgry>/Icos B6.129P2-Icos 17549732 Abnormal CD4-positive T Cell Physiology Icostm1Dgry>/Icos B6.129P2-Icos 17549732 Abnormal Memory B Cell Number Icostm1Dgry>/Icos B6.129P2-Icos 17549732 Increased Plasma Cell Number Icostm1Dgry>/Icos B6.129P2-Icos 17549732 Decreased Plasma Cell Number Icostm1Dgry>/Icos B6.129P2-Icos 17549732 Decreased Germinal Center B Cell Number Icostm1Dgry>/Icos B6.129P2-Icos 17549732 Abnormal Interleukin Secretion Icostm1Dgry>/Icos B6.129P2-Icos 17549732 Decreased Interleukin-4 Secretion Icostm1Dgry>/Icos B6.129P2-Icos 17549732 Decreased Interleukin-5 Secretion Icostm1Dgry>/Icos B6.129P2-Icos 17549732 Decreased IgG Level Icostm1Flv>/Icos NOD.129S1-Icos 18292537 Decreased T Cell Number Icostm1Flv>/Icos NOD.129S1-Icos 18292537 Decreased Anti-insulin Autoantibody Level Icostm1Flv>/Icos NOD.129S1-Icos 18292537 Decreased Autoantibody Level Icostm1Flv>/Icos NOD.129S1-Icos 18292537 Insulitis Icostm1Flv>/Icos NOD.129S1-Icos 18292537 Decreased Susceptibility To Autoimmune Diabetes Icostm1Flv>/Icos NOD.129S1-Icos 18292537 Decreased Interferon-gamma Secretion Icostm1Flv>/Icos NOD.129S1-Icos 18292537 Insulitis Icostm1Flv>/Icos<+ NOD.129S1-Icos 18292537 Decreased Pancreatic Islet Number Icostm1Flv>/Icos<+ NOD.129S1-Icos 18292537 Abnormal Cytokine Level Icostm1Flv>/Icos involves: 129S1/Sv 16200068 Abnormal Immune System Physiology Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142 Abnormal Spleen Morphology Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142 Abnormal B Cell Physiology Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142 Abnormal B Cell Number Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142 Abnormal Peyer's Patch Germinal Center Morphology Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142 Decreased IgA Level Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142 Abnormal Class Switch Recombination Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142 Abnormal B Cell Selection Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142 Decreased CD4-positive T Cell Number Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142 Small Peyer's Patches Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142 Decreased Spleen Germinal Center Number Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142 Decreased IgG1 Level Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142 Decreased IgG2b Level Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142 Decreased Interleukin-4 Secretion Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142 Decreased IgG2c Level Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142 Decreased Interleukin-21 Secretion Icostm1.1Wks>/Icos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 19915142