mRNA IDs | Primary Information | |
NM_020661.1 | Gene Symbol | AICDA |
Protein Name | Activation-induced cytidine deaminase | |
Alternate Names | AID, ARP2, CDA2, HIGM2 | |
Gene Locus | 12p13 |
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Disease name | Characteristic / Associated features | Category | inheritance type |
Activation-induced cytidine deaminase deficiency | Recurrent upper and lower respiratory tract infections; Gastrointestinal infections;Low-absent IgG, IgA; Normal-elevated IgM; Impaired Ig class switch recombination (CSR); Lymphadenopathy; Giant germinal centers in lymph nodes; Normal number of B cells; Defective generation of somatic hypermutations (SHM); Recurrent bacterial infections; No opportunistic infections | Predominantly antibody deficiencies | Autosomal recessive |