CR2
Primary Info
Mutation
Mouse studies
DNA sequencing


External links Primary Information
MGI:88489
ENSMUSG00000026616		 Gene Symbol Cr2
Affected Anatomical Systems hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,renal/urinary system phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id
MGI:1933715 Cr2tm1Crr Targeted (knock-out) targeted mutation 1, Michael C Carroll 8624815
MGI:1932568 Cr2tm1Hmo Targeted (knock-out) targeted mutation 1, Hector Molina 8622941
MGI:3531094 Cr2tm1Tft Targeted (knock-out) targeted mutation 1, Thomas F Tedder 12479818
MGI:4356009 Cr2tm2.1(HLA-A)Crr Targeted (Reporter) targeted mutation 2.1, Michael C Carroll 19706534
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id
Decreased IgG Level Cr2tm1Hmo>/Cr2 involves: 129S7/SvEvBrd 8622941
Decreased IgM Level Cr2tm1Hmo>/Cr2 involves: 129S7/SvEvBrd 8622941
Abnormal Immune System Morphology Cr2tm1Crr>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 10779753
Abnormal Humoral Immune Response Cr2tm1Crr>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 10779753,8624815
Decreased Immunoglobulin Level Cr2tm1Crr>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 10779753
Abnormal Spleen Germinal Center Morphology Cr2tm1Crr>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 8624815
Decreased IgG Level Cr2tm1Crr>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 10779753,8624815
Decreased IgM Level Cr2tm1Crr>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 10779753
Decreased B Cell Number Cr2tm1Crr>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 8624815
Abnormal B-1 B Cell Morphology Cr2tm1Crr>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 8624815
Decreased B-1a Cell Number Cr2tm1Crr>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 10779753
Decreased Spleen Germinal Center Number Cr2tm1Crr>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 10779753,8624815
Decreased Spleen Germinal Center Size Cr2tm1Crr>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 8624815
Decreased IgG2a Level Cr2tm1Crr>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 8624815
Decreased IgG2b Level Cr2tm1Crr>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 8624815
Decreased IgG3 Level Cr2tm1Crr>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 8624815
Abnormal Adaptive Immunity Cr2tm1Tft>/Cr2 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 12479818
Increased Susceptibility To Bacterial Infection Cr2tm1Tft>/Cr2 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 12479818
Decreased IgG Level Cr2tm1Tft>/Cr2 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 12479818
Decreased IgM Level Cr2tm1Tft>/Cr2 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 12479818
Decreased Spleen Germinal Center Number Cr2tm1Tft>/Cr2 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 12479818
Decreased IgG1 Level Cr2tm1Tft>/Cr2 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 12479818
Decreased IgG2b Level Cr2tm1Tft>/Cr2 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 12479818
Decreased IgG3 Level Cr2tm1Tft>/Cr2 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 12479818
Increased Anti-double Stranded DNA Antibody Level Cr2tm1Crr>/Cr2 involves: 129S7/SvEvBrd * C57BL/6J 11067882
Decreased Susceptibility To Injury Cr2tm1Hmo>/Cr2 B6.129S7-Cr2 12165541
Abnormal B Cell Physiology Cr2tm2.1(HLA-A)Crr>/Cr2 involves: C57BL/6 19706534
Abnormal Class Switch Recombination Cr2tm2.1(HLA-A)Crr>/Cr2 involves: C57BL/6 19706534
Abnormal Memory B Cell Differentiation Cr2tm2.1(HLA-A)Crr>/Cr2 involves: C57BL/6 19706534
Abnormal B Cell Physiology Cr2tm1Hmo>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 19706534
Abnormal Class Switch Recombination Cr2tm1Hmo>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 19706534
Abnormal Memory B Cell Differentiation Cr2tm1Hmo>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 19706534
Abnormal B Cell Activation Cr2tm1Hmo>/Cr2 involves: 129S7/SvEvBrd * C57BL/6 19706534
Increased Susceptibility To Bacterial Infection Cr2tm1Hmo>/Cr2 B6.129S7-Cr2 15585877