Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

CD247

External links	Primary Information
MGI:88334 ENSMUSG00000005763	Gene Symbol	Cd247
	Affected Anatomical Systems	hematopoietic system phenotype,immune system phenotype,nervous system phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:2446976 Cd247/Pou2f1tm1Tks Targeted (knock-out) targeted mutation 1, Takashi Saito 8131747 MGI:1857142 Cd247tm1Lov Targeted (knock-out) targeted mutation 1, Paul Love 7688481 MGI:2180466 Cd247tm1Mal Targeted (knock-out) targeted mutation 1, Bernard Malissen 8223444 MGI:2180467 Cd247tm1Mhu Targeted (knock-out) targeted mutation 1, Manley Huang 8223495 MGI:2180484 Cd247tm1Tks Targeted (knock-out) targeted mutation 1, Takashi Saito 8223445
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Brain Morphology Cd247tm1Lov>/Cd247 involves: 129S4/SvJae 11118151 Decreased Thymocyte Number Cd247tm1Lov>/Cd247 involves: 129S4/SvJae 7688481 Abnormal CNS Synaptic Transmission Cd247tm1Lov>/Cd247 involves: 129S4/SvJae 11118151 Abnormal T-helper 1 Cell Morphology Cd247tm1Lov>/Cd247 involves: 129S4/SvJae 7688481 Abnormal Superior Colliculus Cd247tm1Lov>/Cd247 involves: 129S4/SvJae 11118151 Absent Long Term Depression Cd247tm1Lov>/Cd247 involves: 129S4/SvJae 11118151 Decreased Double-positive T Cell Number Cd247tm1Lov>/Cd247 involves: 129S4/SvJae 7688481 Abnormal T-helper 1 Physiology Cd247tm1Lov>/Cd247 involves: 129S4/SvJae 9529325 Abnormal Excitatory Postsynaptic Potential Cd247tm1Lov>/Cd247 involves: 129S4/SvJae 11118151 Enhanced Long Term Potentiation Cd247tm1Lov>/Cd247 involves: 129S4/SvJae 11118151 Abnormal Lateral Geniculate Nucleus Morphology Cd247tm1Lov>/Cd247 involves: 129S4/SvJae 11118151 Decreased CD4-positive T Cell Number Cd247tm1Lov>/Cd247 involves: 129S4/SvJae 7688481 Abnormal Single-positive T Cell Number Cd247tm1Lov>/Cd247 involves: 129S4/SvJae 7688481 Absent Gamma-delta Intraepithelial T Cell Cd247tm1Lov>/Cd247 involves: 129S4/SvJae 9529325 Postnatal Lethality Cd247/Pou2f1tm1Tks>/Cd247/Pou2f1 involves: 129P2/OlaHsd * C57BL/6 8131747 Thymus Hypoplasia Cd247tm1Mhu>/Cd247 involves: 129S7/SvEvBrd * C57BL/6 8223495 Abnormal T Cell Differentiation Cd247tm1Mhu>/Cd247 involves: 129S7/SvEvBrd * C57BL/6 8223495 Enlarged Lymph Nodes Cd247tm1Mhu>/Cd247 involves: 129S7/SvEvBrd * C57BL/6 8223495 Enlarged Spleen Cd247tm1Mhu>/Cd247 involves: 129S7/SvEvBrd * C57BL/6 8223495 Small Thymus Cd247tm1Mhu>/Cd247 involves: 129S7/SvEvBrd * C57BL/6 8223495 Abnormal Thymus Cortex Morphology Cd247tm1Mhu>/Cd247 involves: 129S7/SvEvBrd * C57BL/6 8223495 Abnormal Thymus Medulla Morphology Cd247tm1Mhu>/Cd247 involves: 129S7/SvEvBrd * C57BL/6 8223495 Decreased Thymocyte Number Cd247tm1Mhu>/Cd247 involves: 129S7/SvEvBrd * C57BL/6 8223495 Decreased T Cell Proliferation Cd247tm1Mhu>/Cd247 involves: 129S7/SvEvBrd * C57BL/6 8223495 Increased Double-negative T Cell Number Cd247tm1Mhu>/Cd247 involves: 129S7/SvEvBrd * C57BL/6 8223495 Decreased Double-positive T Cell Number Cd247tm1Mhu>/Cd247 involves: 129S7/SvEvBrd * C57BL/6 8223495 Decreased CD4-positive T Cell Number Cd247tm1Mhu>/Cd247 involves: 129S7/SvEvBrd * C57BL/6 8223495 Decreased CD8-positive T Cell Number Cd247tm1Mhu>/Cd247 involves: 129S7/SvEvBrd * C57BL/6 8223495 Decreased Splenocyte Proliferation Cd247tm1Mhu>/Cd247 involves: 129S7/SvEvBrd * C57BL/6 8223495 Abnormal Thymus Medulla Morphology Cd247tm1Tks>/Cd247 involves: 129P2/OlaHsd * C57BL/6 8223445 Decreased Thymocyte Number Cd247tm1Tks>/Cd247 involves: 129P2/OlaHsd * C57BL/6 8223445 Abnormal T Cell Proliferation Cd247tm1Tks>/Cd247 involves: 129P2/OlaHsd * C57BL/6 8223445 Decreased Double-positive T Cell Number Cd247tm1Tks>/Cd247 involves: 129P2/OlaHsd * C57BL/6 8223445 Decreased CD4-positive T Cell Number Cd247tm1Tks>/Cd247 involves: 129P2/OlaHsd * C57BL/6 8223445 Decreased CD8-positive T Cell Number Cd247tm1Tks>/Cd247 involves: 129P2/OlaHsd * C57BL/6 8223445 Decreased Single-positive T Cell Number Cd247tm1Tks>/Cd247 involves: 129P2/OlaHsd * C57BL/6 8223445 Abnormal Alpha-beta Intraepithelial T Cell Morphology Cd247tm1Tks>/Cd247 involves: 129P2/OlaHsd * C57BL/6 8223445 Abnormal NK Cell Physiology Cd247tm1Tks>/Cd247 B6.129P2-Cd247 11123272 Abnormal NK Cell Morphology Cd247tm1Tks>/Cd247 B6.129P2-Cd247 11123272 Enhanced NK Cell Cytolysis Cd247tm1Tks>/Cd247 B6.129P2-Cd247 11123272 Decreased NK T Cell Number Cd247tm1Tks>/Cd247 B6.129P2-Cd247 7650493 Increased Interferon-gamma Secretion Cd247tm1Tks>/Cd247 B6.129P2-Cd247 11123272 Abnormal T Cell Differentiation Cd247tm1Mal>/Cd247 either: C57BL/6-Cd247 or (involves: BALB/c * C57BL/6) 8223444 Decreased Thymocyte Number Cd247tm1Mal>/Cd247 either: C57BL/6-Cd247 or (involves: BALB/c * C57BL/6) 8223444 Increased Double-negative T Cell Number Cd247tm1Mal>/Cd247 either: C57BL/6-Cd247 or (involves: BALB/c * C57BL/6) 8223444 Decreased Double-positive T Cell Number Cd247tm1Mal>/Cd247 either: C57BL/6-Cd247 or (involves: BALB/c * C57BL/6) 8223444 Decreased CD4-positive T Cell Number Cd247tm1Mal>/Cd247 either: C57BL/6-Cd247 or (involves: BALB/c * C57BL/6) 8223444 Decreased CD8-positive T Cell Number Cd247tm1Mal>/Cd247 either: C57BL/6-Cd247 or (involves: BALB/c * C57BL/6) 8223444 Decreased Single-positive T Cell Number Cd247tm1Mal>/Cd247 either: C57BL/6-Cd247 or (involves: BALB/c * C57BL/6) 8223444 Abnormal Intraepithelial T Cell Morphology Cd247tm1Mal>/Cd247 either: C57BL/6-Cd247 or (involves: BALB/c * C57BL/6) 8223444 Abnormal T Cell Differentiation Cd247tm1Mal>/Cd247 involves: C57BL/6 7520000 Abnormal Double-negative T Cell Morphology Cd247tm1Mal>/Cd247 involves: C57BL/6 10072519,7520000 Decreased Double-positive T Cell Number Cd247tm1Mal>/Cd247 involves: C57BL/6 10072519 Abnormal Thymocyte Activation Cd247tm1Mal>/Cd247 involves: C57BL/6 10072519 Abnormal T Cell Morphology Cd247tm1Mal>/Cd247 involves: C57BL/6 10072519