Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

IGHM

External links	Primary Information
MGI:96448 ENSMUSG00000076617	Gene Symbol	Igh-6
	Affected Anatomical Systems	cardiovascular system phenotype,cellular phenotype,digestive/alimentary phenotype,endocrine/exocrine gland phenotype,growth/size phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,life span-post-weaning/aging,no phenotypic analysis,renal/urinary system phenotype,respiratory system phenotype,skin/coat/nails phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3581517 Igh-6tm1(Bcl6)Rdf Targeted (knock-in) targeted mutation 1, Riccardo Dalla-Favera 15894265 MGI:1857187 Igh-6tm1Cgn Targeted (knock-out) targeted mutation 1, University of Cologne 1901381 MGI:1934014 Igh-6tm1Che Targeted (knock-out) targeted mutation 1, Jianzhu Chen 9590224 MGI:3037070 Igh-6tm1Fbb Targeted (knock-out) targeted mutation 1, Frank Brombacher 9655395 MGI:2447178 Igh-6tm1Msn Targeted (knock-out) targeted mutation 1, Michael S Neuberger 9707605 MGI:3582575 Igh-6tm1Sls Targeted (knock-out) targeted mutation 1, Erik Selsing 11148220 MGI:3701077 Igh-6tm2.1Bgmn Targeted (knock-out) targeted mutation 2.1, Marianne Bruggemann 15475246 MGI:2445756 Igh-6tm2.1Che Targeted (knock-out) targeted mutation 2.1, Jianzhu Chen 10640761 MGI:3701076 Igh-6tm2Bgmn Targeted (Floxed/Frt) targeted mutation 2, Marianne Bruggeman 15475246 MGI:2445751 Igh-6tm2Che Targeted (knock-out) targeted mutation 2, Jianzhu Chen 10640761 MGI:3774509 Igh-6tm3Bgmn Targeted (other) targeted mutation 3, Marianne Bruggemann 11717190 MGI:3774510 Igh-6tm4Bgmn Targeted (other) targeted mutation 4, Marianne Bruggemann 11717190
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Immune System Physiology Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 9590224 Abnormal Humoral Immune Response Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 9590224 Abnormal Spleen Morphology Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 17899553 Abnormal B Cell Physiology Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 9590224 Abnormal Spleen Marginal Zone Morphology Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 17899553 Abnormal Spleen White Pulp Morphology Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 17899553 Abnormal Spleen Germinal Center Morphology Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 9590224 Abnormal Spleen Periarteriolar Lymphoid Sheath Morphology Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 17899553 Decreased IgM Level Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 9590224 Increased IgA Level Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 9590224 Increased B-1 B Cell Number Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 9590224 Abnormal Follicular Dendritic Cell Antigen Presentation Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 9590224 Abnormal Metallophillic Macrophage Morphology Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 17899553 Abnormal Spleen B Cell Follicle Morphology Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 17899553 Decreased IgG1 Level Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 9590224 Decreased IgG2b Level Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 9590224 Increased IgG2a Level Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 9590224 Increased IgG3 Level Igh-6tm1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 9590224 Abnormal Lymphatic Vessel Morphology Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas * C57BL/6 16272283 Abnormal Respiratory System Physiology Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas * C57BL/6 16272283 Abnormal B Cell Differentiation Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas * C57BL/6 1545868,1901381 Decreased IgM Level Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas * C57BL/6 1545868 Arrested B Cell Differentiation Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas * C57BL/6 1545868 Abnormal Response To Infection Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas * C57BL/6 16272283 Absent Mature B Cells Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas * C57BL/6 1545868 Absent Immature B Cells Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas * C57BL/6 1545868 Increased Susceptibility To Viral Infection Igh-6tm1Fbb>/Igh-6 involves: BALB/cJ 9655395 Premature Death Igh-6tm1(Bcl6)Rdf>/? involves: 129/Sv * C57BL/6 15894265 Abnormal Spleen Morphology Igh-6tm1(Bcl6)Rdf>/? involves: 129/Sv * C57BL/6 15894265 Enlarged Spleen Igh-6tm1(Bcl6)Rdf>/? involves: 129/Sv * C57BL/6 15894265 Decreased Immunoglobulin Level Igh-6tm1(Bcl6)Rdf>/? involves: 129/Sv * C57BL/6 15894265 B Cell Derived Lymphoma Igh-6tm1(Bcl6)Rdf>/? involves: 129/Sv * C57BL/6 15894265 Abnormal B Cell Proliferation Igh-6tm1(Bcl6)Rdf>/? involves: 129/Sv * C57BL/6 15894265 Decreased Plasma Cell Number Igh-6tm1(Bcl6)Rdf>/? involves: 129/Sv * C57BL/6 15894265 Abnormal Spleen B Cell Follicle Morphology Igh-6tm1(Bcl6)Rdf>/? involves: 129/Sv * C57BL/6 15894265 Increased Spleen White Pulp Amount Igh-6tm1(Bcl6)Rdf>/? involves: 129/Sv * C57BL/6 15894265 Increased Spleen Germinal Center Number Igh-6tm1(Bcl6)Rdf>/? involves: 129/Sv * C57BL/6 15894265 Decreased IgG Level Igh-6tm1Sls>/Igh-6 Not Specified 11148220 Increased IgM Level Igh-6tm1Sls>/Igh-6 Not Specified 11148220 Abnormal Class Switch Recombination Igh-6tm1Sls>/Igh-6 Not Specified 11148220 Decreased IgG1 Level Igh-6tm1Sls>/Igh-6 Not Specified 11148220 Decreased IgG2b Level Igh-6tm1Sls>/Igh-6 Not Specified 11148220 Decreased IgG3 Level Igh-6tm1Sls>/Igh-6 Not Specified 11148220 Insulitis Igh-6tm1Cgn>/Igh-6 NODCaj.129S2-Igh-6 15448087 Decreased Susceptibility To Autoimmune Diabetes Igh-6tm1Cgn>/Igh-6 NOD.129S2-Igh-6 8920894 Increased Susceptibility To Autoimmune Diabetes Igh-6tm1Cgn>/Igh-6<+ NOD.129S2-Igh-6 8920894 Abnormal Humoral Immune Response Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6/J 11035071 Abnormal Respiratory System Physiology Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6/J 11937563 Abnormal Spleen Morphology Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6/J 11733579 Decreased Immunoglobulin Level Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6/J 11035071 Decreased IgE Level Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6/J 11937563 Decreased IgG Level Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6/J 11035071,11937563 Arrested B Cell Differentiation Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6/J 11035071 Increased Susceptibility To Parasitic Infection Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6/J 11748158 Abnormal Cytokine Secretion Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6/J 11067910 Decreased Spleen Weight Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6/J 11733579 Decreased CD4-positive T Cell Number Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6/J 11067910,11733579 Decreased CD8-positive T Cell Number Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6/J 11733579 Decreased Dendritic Cell Number Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6/J 11733579 Decreased IgG1 Level Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6/J 11937563 Abnormal Antigen Presentation Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas 10843660 Abnormal Spleen Marginal Sinus Morphology Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas 15004164 Decreased IgA Level Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas 19727123 Decreased IgG Level Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas 19727123 Arrested B Cell Differentiation Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas 15475246 Decreased T Cell Proliferation Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas 10843660 Abnormal CD4-positive T Cell Physiology Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas 10843660 Decreased Susceptibility To Type IV Hypersensitivity Reaction Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas 10843660 Absent Follicular Dendritic Cells Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas 15004164 Absent Mature B Cells Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas 15475246 Abnormal Spleen Marginal Zone Macrophage Morphology Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas 15004164 Abnormal Metallophillic Macrophage Morphology Igh-6tm1Cgn>/Igh-6 involves: 129S2/SvPas 15004164 Abnormal Immune System Physiology Igh-6tm2.1Bgmn>/Igh-6 involves: 129/Sv * C57BL/6 * CBA 15475246 Decreased Immunoglobulin Level Igh-6tm2.1Bgmn>/Igh-6 involves: 129/Sv * C57BL/6 * CBA 15475246 Arrested B Cell Differentiation Igh-6tm2.1Bgmn>/Igh-6 involves: 129/Sv * C57BL/6 * CBA 15475246 Absent Mature B Cells Igh-6tm2.1Bgmn>/Igh-6 involves: 129/Sv * C57BL/6 * CBA 15475246 Arrested B Cell Differentiation Igh-6tm1Cgn>/Igh-6<+ involves: 129S2/SvPas * C57BL/6 1901381 Abnormal Intestinal Epithelium Morphology Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6 11884426 Abnormal CD8 Positive, Alpha-beta Intraepithelial T Cell Morphology Igh-6tm1Cgn>/Igh-6 B6.129S2-Igh-6 11884426 Abnormal T Cell Proliferation Igh-6tm1Cgn>/Igh-6 NOD.129S2-Igh-6/DvsJ 12516557 Decreased Susceptibility To Autoimmune Diabetes Igh-6tm1Cgn>/Igh-6 NOD.129S2-Igh-6/DvsJ 12516557 Abnormal T Cell Number Igh-6tm1Cgn>/Igh-6 NOD.129S2-Igh-6/DvsJ 12516557 Absent B Cells Igh-6tm1Cgn>/Igh-6 NOD.129S2-Igh-6/DvsJ 12516557 Abnormal Spleen B Cell Follicle Morphology Igh-6tm1Cgn>/Igh-6 NOD.129S2-Igh-6/DvsJ 12516557 Decreased IgM Level Igh-6tm3Bgmn>/Igh-6 involves: 129/Sv 11717190 Decreased B Cell Proliferation Igh-6tm3Bgmn>/Igh-6 involves: 129/Sv 11717190 Increased B-1 B Cell Number Igh-6tm3Bgmn>/Igh-6 involves: 129/Sv 11717190 Decreased Mature B Cell Number Igh-6tm3Bgmn>/Igh-6 involves: 129/Sv 11717190 Decreased Immature B Cell Number Igh-6tm3Bgmn>/Igh-6 involves: 129/Sv 11717190 Abnormal B Cell Activation Igh-6tm3Bgmn>/Igh-6 involves: 129/Sv 11717190 Decreased IgM Level Igh-6tm4Bgmn>/Igh-6 involves: 129/Sv 11717190 Decreased B Cell Proliferation Igh-6tm4Bgmn>/Igh-6 involves: 129/Sv 11717190 Increased B-1 B Cell Number Igh-6tm4Bgmn>/Igh-6 involves: 129/Sv 11717190 Decreased Mature B Cell Number Igh-6tm4Bgmn>/Igh-6 involves: 129/Sv 11717190 Decreased Immature B Cell Number Igh-6tm4Bgmn>/Igh-6 involves: 129/Sv 11717190 Abnormal B Cell Activation Igh-6tm4Bgmn>/Igh-6 involves: 129/Sv 11717190 No Abnormal Phenotype Detected Igh-6tm2.1Che>/Igh-6 involves: 129S4/SvJae * C57BL/6 10640761 Decreased IgM Level Igh-6tm1Msn>/Igh-6<+ involves: 129S/SvEv 9707605 Decreased IgM Level Igh-6tm1Msn>/Igh-6 involves: 129S/SvEv 9707605 Abnormal Immature B Cell Morphology Igh-6tm1Msn>/Igh-6 involves: 129S/SvEv 9707605 Abnormal B-1a B Cell Morphology Igh-6tm1Msn>/Igh-6 involves: 129S/SvEv 9707605 Abnormal Mature B Cell Morphology Igh-6tm1Msn>/Igh-6 involves: 129S/SvEv 9707605 Decreased IgG1 Level Igh-6tm1Msn>/Igh-6 involves: 129S/SvEv 9707605 Increased IgG3 Level Igh-6tm1Msn>/Igh-6 involves: 129S/SvEv 9707605 Kidney Inflammation Igh-6tm1Msn>/Igh-6 involves: 129S/SvEv * C57BL/6 10748243 Increased Autoantibody Level Igh-6tm1Msn>/Igh-6 involves: 129S/SvEv * C57BL/6 10748243 Increased Anti-double Stranded DNA Antibody Level Igh-6tm1Msn>/Igh-6 involves: 129S/SvEv * C57BL/6 10748243 Decreased IgM Level Igh-6tm1Msn>/Igh-6 B6.129S-Igh-6 12471099 Abnormal B-1a B Cell Morphology Igh-6tm1Msn>/Igh-6 B6.129S-Igh-6 12471099 Decreased Follicular B Cell Number Igh-6tm1Msn>/Igh-6 B6.129S-Igh-6 12471099 Increased Marginal Zone B Cell Number Igh-6tm1Msn>/Igh-6 B6.129S-Igh-6 12471099 Abnormal Splenic Cell Ratio Igh-6tm1Msn>/Igh-6 B6.129S-Igh-6 12471099 Increased Susceptibility To Parasitic Infection Igh-6tm1Che>/Igh-6 involves: 129 * C57BL/6 11748158 Abnormal B Cell Differentiation Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Small Lymph Nodes Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Decreased IgA Level Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Decreased IgG Level Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Decreased IgM Level Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Decreased B Cell Number Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Increased B Cell Number Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Decreased B Cell Proliferation Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Increased B Cell Proliferation Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Decreased B-1 B Cell Number Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Increased Plasma Cell Number Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Abnormal Plasma Cell Differentiation Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Decreased Peyer's Patch Number Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Small Peyer's Patches Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Decreased Follicular B Cell Number Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Decreased Marginal Zone B Cell Number Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Increased Pro-B Cell Number Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Decreased Transitional Stage B Cell Number Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Decreased Pre-B Cell Number Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Decreased Mature B Cell Number Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Decreased IgG1 Level Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Decreased IgG2a Level Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609 Decreased IgG3 Level Igh-6tm1.1(IGH-2)Cog>/Igh-6 involves: 129P2/OlaHsd * C57BL/6 * FVB/N 20133609