Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

IL2RG

External links	Primary Information
MGI:96551 ENSMUSG00000031304	Gene Symbol	Il2rg
	Affected Anatomical Systems	cellular phenotype,digestive/alimentary phenotype,hematopoietic system phenotype,immune system phenotype,life span-post-weaning/aging,no phenotypic analysis,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:1861947 Il2rgtm1Cgn Targeted (knock-out) targeted mutation 1, University of Cologne 7831294 MGI:3690461 Il2rgtm1Krf Targeted (knock-out) targeted mutation 1, Paul Krimpenfort MGI:2429736 Il2rgtm1Sug Targeted (knock-out) targeted mutation 1, Kazuo Sugamura 8562967 MGI:1857455 Il2rgtm1Wjl Targeted (knock-out) targeted mutation 1, Warren J Leonard 7697543 MGI:3776426 Il2rgtm2Cgn Targeted (Floxed/Frt) targeted mutation 2, University of Cologne 7831294
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Hematopoietic System Morphology/development Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Thymus Hypoplasia Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Spleen Hypoplasia Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Decreased IgE Level Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Decreased IgM Level Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Decreased T Cell Number Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Impaired NK Cell Cytolysis Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Decreased T Cell Proliferation Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Absent Peyer's Patches Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Abnormal Thymocyte Activation Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Abnormal Class Switch Recombination Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Absent NK Cells Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Decreased Plasma Cell Number Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Decreased Pre-B Cell Number Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Decreased Mature B Cell Number Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Abnormal Leukocyte Morphology Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Abnormal Alpha-beta Intraepithelial T Cell Morphology Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Absent Spleen Germinal Center Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Decreased Spleen White Pulp Amount Il2rgtm1Cgn>/Il2rg involves: 129 * CB20 7831294 Thymus Hypoplasia Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294,9334367 Spleen Hypoplasia Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Decreased IgE Level Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Decreased IgM Level Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Decreased T Cell Number Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Impaired NK Cell Cytolysis Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Decreased T Cell Proliferation Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Absent Peyer's Patches Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Abnormal Thymocyte Activation Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Abnormal Class Switch Recombination Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Absent NK Cells Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Decreased Plasma Cell Number Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Decreased Pre-B Cell Number Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Decreased Mature B Cell Number Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Abnormal Leukocyte Morphology Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Absent Gamma-delta T Cells Il2rgtm1Cgn>/Y involves: 129 * CB20 9334367 Absent Gamma-delta Intraepithelial T Cell Il2rgtm1Cgn>/Y involves: 129 * CB20 9334367 Abnormal Gamma-delta T Cell Differentiation Il2rgtm1Cgn>/Y involves: 129 * CB20 9334367 Abnormal Alpha-beta Intraepithelial T Cell Morphology Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Absent Spleen Germinal Center Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Decreased Spleen White Pulp Amount Il2rgtm1Cgn>/Y involves: 129 * CB20 7831294 Abnormal Myelopoiesis Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Abnormal Immune System Cell Morphology Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Thymus Hypoplasia Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Abnormal Immunoglobulin Level Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Small Lymph Nodes Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Enlarged Spleen Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Increased Monocyte Cell Number Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Increased Neutrophil Cell Number Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Small Thymus Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Decreased Thymocyte Number Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Decreased IgG Level Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Arrested B Cell Differentiation Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Abnormal Proerythroblast Morphology Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Decreased Lymphocyte Cell Number Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Decreased T Cell Number Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Absent Spleen White Pulp Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Decreased Thymus Cortex Area Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Abnormal Immune System Organ Morphology Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Abnormal Immune Serum Protein Physiology Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Increased Macrophage Cell Number Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Absent NK Cells Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Enlarged Peyer's Patches Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Increased Megakaryocyte Cell Number Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Decreased IgG3 Level Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Abnormal Splenic Cell Ratio Il2rgtm1Sug>/Y either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 8562967 Abnormal Cell-mediated Immunity Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 15263024 Abnormal Gut-associated Lymphoid Tissue Morphology Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Thymus Cortex Hypoplasia Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Abnormal Cecum Morphology Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Small Lymph Nodes Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Spleen Hyperplasia Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Spleen Hypoplasia Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Abnormal Basophil Physiology Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Decreased Immunoglobulin Level Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Abnormal B Cell Number Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 15263024 Thymus Hyperplasia Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 15263024 Small Thymus Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Abnormal Mast Cell Physiology Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Abnormal CD4-positive T Cell Morphology Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 15263024 Abnormal Lymphocyte Morphology Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 15263024 Abnormal Immune System Organ Morphology Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 15263024 Abnormal Immune Serum Protein Physiology Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 15263024 Impaired NK Cell Cytolysis Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Decreased T Cell Proliferation Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Decreased Double-negative T Cell Number Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Decreased Double-positive T Cell Number Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Abnormal Mesenteric Lymph Node Morphology Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Abnormal Thymocyte Activation Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Absent NK Cells Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Decreased CD8-positive T Cell Number Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Decreased Single-positive T Cell Number Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Decreased Immature B Cell Number Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Absent Gamma-delta T Cells Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Absent Gamma-delta Intraepithelial T Cell Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Decreased Interferon-gamma Secretion Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Decreased Interleukin-2 Secretion Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Decreased Interleukin-4 Secretion Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Cecum Inflammation Il2rgtm1Wjl>/Y involves: 129S4/SvJae * C57BL/6 7697543 Decreased Thymocyte Number Il2rgtm1Krf>/Il2rg either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N) 10523604 Abnormal Dendritic Cell Physiology Il2rgtm1Wjl>/Il2rg B6.129S4-Il2rg/J 16020505 Decreased Myeloid Dendritic Cell Number Il2rgtm1Wjl>/Il2rg B6.129S4-Il2rg/J 16020505 Abnormal Splenic Cell Ratio Il2rgtm1Wjl>/Il2rg B6.129S4-Il2rg/J 16020505 Abnormal Estrous Cycle Il2rgtm1Sug>/Il2rg B6.129-Il2rg 12069389 Abnormal Maternal Decidual Layer Morphology Il2rgtm1Sug>/Il2rg B6.129-Il2rg 12069389 Absent Uterine NK Cells Il2rgtm1Sug>/Il2rg B6.129-Il2rg 12069389 Prolonged Estrous Cycle Il2rgtm1Sug>/Il2rg B6.129-Il2rg 12069389 Prolonged Diestrus Il2rgtm1Sug>/Il2rg B6.129-Il2rg 12069389 Prolonged Metestrus Il2rgtm1Sug>/Il2rg B6.129-Il2rg 12069389