JAK3
Primary Info
Mutation
Mouse studies
DNA sequencing


External links Primary Information
MGI:99928
ENSMUSG00000031805		 Gene Symbol Jak3
Affected Anatomical Systems digestive/alimentary phenotype,hematopoietic system phenotype,immune system phenotype,life span-post-weaning/aging
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id
MGI:3611885 Jak3bfy Chemically induced (ENU) buffy
MGI:3527456 Jak3tm1Flv Targeted (knock-out) targeted mutation 1, Richard A Flavell 8887051
MGI:2675061 Jak3tm1Jni Targeted (knock-out) targeted mutation 1, James N Ihle 7481769
MGI:1857276 Jak3tm1Ljb Targeted (knock-out) targeted mutation 1, Leslie J Berg 7481767
MGI:3578806 Jak3tm1Tks Targeted (knock-out) targeted mutation 1, Takashi Saito 8777722
MGI:3614703 Jak3wil Not Specified willow
MGI:3665252 Jak3X887Y Spontaneous X887Y 16878135
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id
Abnormal Immune System Physiology Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Abnormal Leukocyte Physiology Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 15147562
Thymus Hypoplasia Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Small Lymph Nodes Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Spleen Hypoplasia Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Abnormal T Cell Activation Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Small Thymus Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Decreased IgG Level Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Arrested B Cell Differentiation Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Abnormal Response To Infection Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Decreased T Cell Proliferation Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Abnormal Lymphocyte Physiology Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 15147562
Abnormal B Cell Morphology Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Lymph Node Hypoplasia Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Small Peyer's Patches Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Decreased Mature B Cell Number Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Decreased Immature B Cell Number Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Abnormal Splenic Cell Ratio Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae * C57BL/6 7481767
Thymus Hypoplasia Jak3tm1Flv>/Jak3 involves: 129S1/Sv 8887051
Small Lymph Nodes Jak3tm1Flv>/Jak3 involves: 129S1/Sv 8887051
Enlarged Spleen Jak3tm1Flv>/Jak3 involves: 129S1/Sv 8887051
Arrested B Cell Differentiation Jak3tm1Flv>/Jak3 involves: 129S1/Sv 8887051
Abnormal T Cell Proliferation Jak3tm1Flv>/Jak3 involves: 129S1/Sv 8887051
Increased CD4-positive T Cell Number Jak3tm1Flv>/Jak3 involves: 129S1/Sv 8887051
Decreased CD8-positive T Cell Number Jak3tm1Flv>/Jak3 involves: 129S1/Sv 8887051
Abnormal Lymphopoiesis Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Thymus Hypoplasia Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Abnormal T Cell Physiology Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Abnormal B Cell Differentiation Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Small Spleen Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Abnormal Spleen White Pulp Morphology Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Spleen Hypoplasia Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Abnormal Spleen Periarteriolar Lymphoid Sheath Morphology Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Abnormal Thymus Cortex Morphology Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Abnormal Thymus Medulla Morphology Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Decreased Thymocyte Number Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Abnormal CD4-positive T Cell Morphology Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Decreased B Cell Number Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Decreased Thymus Cortex Area Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Abnormal Mesenteric Lymph Node Morphology Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Absent Lymph Nodes Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Abnormal T Cell Number Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Abnormal T Cell Morphology Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Absent NK Cells Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Decreased Pre-B Cell Number Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Absent Hassall's Corpuscle Jak3tm1Tks>/Jak3 involves: 129P2/OlaHsd * C57BL/6 8777722
Abnormal Leukocyte Physiology Jak3tm1Tks>/Jak3<+ involves: 129P2/OlaHsd * C57BL/6 8777722
Abnormal Lymphopoiesis Jak3bfy>/Jak3 C57BL/6JApb-Jak3/Apb
Small Thymus Jak3bfy>/Jak3 C57BL/6JApb-Jak3/Apb
Decreased Thymocyte Number Jak3bfy>/Jak3 C57BL/6JApb-Jak3/Apb
Decreased Lymphocyte Cell Number Jak3bfy>/Jak3 C57BL/6JApb-Jak3/Apb
Decreased B Cell Number Jak3bfy>/Jak3 C57BL/6JApb-Jak3/Apb
Decreased T Cell Number Jak3bfy>/Jak3 C57BL/6JApb-Jak3/Apb
Diarrhea Jak3bfy>/Jak3 C57BL/6JApb-Jak3/Apb
Abnormal T Cell Subpopulation Ratio Jak3bfy>/Jak3 C57BL/6JApb-Jak3/Apb
Premature Death Jak3wil>/Jak3 C57BL/6Apb-Jak3
Decreased Leukocyte Cell Number Jak3wil>/Jak3 C57BL/6Apb-Jak3
Rectal Prolapse Jak3wil>/Jak3 C57BL/6Apb-Jak3
Arrested B Cell Differentiation Jak3wil>/Jak3 C57BL/6Apb-Jak3
Diarrhea Jak3wil>/Jak3 C57BL/6Apb-Jak3
Large Intestinal Inflammation Jak3wil>/Jak3 C57BL/6Apb-Jak3
Decreased CD8-positive T Cell Number Jak3wil>/Jak3 C57BL/6Apb-Jak3
Abnormal Hematopoietic System Morphology/development Jak3X887Y>/Jak3 Not Specified 16878135
Abnormal Lymph Node Morphology Jak3X887Y>/Jak3 Not Specified 16878135
Abnormal Spleen Morphology Jak3X887Y>/Jak3 Not Specified 16878135
Abnormal Thymus Morphology Jak3X887Y>/Jak3 Not Specified 16878135
Abnormal Lymphocyte Morphology Jak3X887Y>/Jak3 Not Specified 16878135
Abnormal Immune System Organ Morphology Jak3X887Y>/Jak3 Not Specified 16878135
Abnormal Myelopoiesis Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 10419884
Abnormal Spleen Morphology Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 10419884
Chronic Inflammation Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 10419884
Thymus Hypoplasia Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 9016869
Abnormal T Cell Physiology Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 9016869
Abnormal T Cell Differentiation Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 11034372
Increased Leukocyte Cell Number Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 10419884
Enlarged Spleen Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 10419884
Abnormal Spleen White Pulp Morphology Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 10419884
Abnormal T Cell Activation Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 10419884,9016869
Increased Monocyte Cell Number Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 10419884
Increased Neutrophil Cell Number Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 10419884
Decreased Thymocyte Number Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 11034372
Abnormal Erythropoiesis Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 10419884
Decreased Lymphocyte Cell Number Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 10419884
Decreased T Cell Proliferation Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 9016869
Absent Lymph Nodes Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 9016869
Absent B Cells Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 9016869
Abnormal Leukocyte Morphology Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 10419884
Abnormal Thymus Cell Ratio Jak3tm1Ljb>/Jak3 involves: 129S4/SvJae 9016869
Increased Leukocyte Cell Number Jak3tm1Ljb>/Jak3<+ involves: 129S4/SvJae 10419884
Increased Monocyte Cell Number Jak3tm1Ljb>/Jak3<+ involves: 129S4/SvJae 10419884
Increased Neutrophil Cell Number Jak3tm1Ljb>/Jak3<+ involves: 129S4/SvJae 10419884
Decreased Lymphocyte Cell Number Jak3tm1Ljb>/Jak3<+ involves: 129S4/SvJae 10419884
Abnormal Leukocyte Morphology Jak3tm1Ljb>/Jak3<+ involves: 129S4/SvJae 10419884
Abnormal Dendritic Cell Physiology Jak3tm1Ljb>/Jak3 B6;129S4-Jak3/J 16020505
Abnormal Dendritic Cell Morphology Jak3tm1Ljb>/Jak3 B6;129S4-Jak3/J 16020505
Decreased CD4-positive T Cell Number Jak3tm1Ljb>/Jak3 B6;129S4-Jak3/J 16020505
Decreased CD8-positive T Cell Number Jak3tm1Ljb>/Jak3 B6;129S4-Jak3/J 16020505
Abnormal Dendritic Cell Differentiation Jak3tm1Ljb>/Jak3 B6;129S4-Jak3/J 16020505
Decreased Myeloid Dendritic Cell Number Jak3tm1Ljb>/Jak3 B6;129S4-Jak3/J 16020505
Abnormal Splenic Cell Ratio Jak3tm1Ljb>/Jak3 B6;129S4-Jak3/J 16020505